A kind of metal sulfide nanomaterial and its preparation method and application

A technology of metal sulfide and nanomaterials, applied in the field of nanomaterials, can solve the problems of side effects, insufficient penetration depth of irradiation, etc., and achieve the effects of reducing absorption, optimizing tumor treatment effect, and improving efficiency

Active Publication Date: 2020-12-08
INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
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Problems solved by technology

However, most of these materials are sensitive to ultraviolet / visible light, and ultraviolet / visible light has insufficient penetration depth in the living body and may have certain side effects

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  • A kind of metal sulfide nanomaterial and its preparation method and application
  • A kind of metal sulfide nanomaterial and its preparation method and application
  • A kind of metal sulfide nanomaterial and its preparation method and application

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preparation example Construction

[0042] The present invention also discloses a method for preparing the above-mentioned metal sulfide nanomaterial: the method includes the following steps:

[0043]Step 1, using bismuth salt as a precursor, adding an organic solvent, heating and reacting for a period of time to obtain a solution; in this step, the bismuth salt is bismuth nitrate, bismuth chloride or bismuth dodecanoate; the organic solvent is oleic acid One or more of oleylamine and octadecene; the molar concentration of bismuth element in the solution obtained by this step is 0.05~0.5mol / L, for example, 0.05mol / L, 0.1mol / L, 0.2mol / L, 0.3mol / L, 0.4mol / L or 0.5mol / L; the heating temperature in this step is 100-200°C, such as 100°C, 120°C, 140°C, 170°C, 180°C or 200°C; The reaction time in the step is 10 to 30 minutes, such as 10 minutes, 20 minutes or 30 minutes;

[0044] Step 2, add sulfur powder dissolved in oleylamine to the solution obtained in step 1, continue heating and reacting for a certain period of...

Embodiment 1

[0049] (1) 3mmol of BiCl 3 Add it into a 100mL three-neck round bottom flask, then add 10mL of oleic acid and 10mL of oleylamine, then add a stirring bar to stir, raise the temperature to 170°C and react for 30min to obtain the reaction system A;

[0050] (2) Dissolving 10 mmol of elemental sulfur in 5 mL of oleylamine and ultrasonically dissolving it sufficiently to obtain solution I;

[0051] (3) Quickly add solution I to reaction system A, and continue to react at 170° C. for 10 minutes to obtain reaction system B;

[0052] (4) Stop the reaction. After the reaction system B is cooled to room temperature, transfer system B to a centrifuge tube, centrifuge at 8000 rpm for 3 minutes, and then take the precipitate and resuspend it in 20 mL of cyclohexane to prepare solution II ;

[0053] (5) Take 10 mL of solution II, add 100 μL of Tween-20, and then add 30 mL of deionized water. After ultrasonication for 30 minutes, heat the water bath to 70 ° C and stir until the solution i...

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Abstract

The invention discloses a metal sulfide nanomaterial, a preparation method and application thereof. The metal sulfide nanomaterial includes bismuth sulfide nanorods and a high polymer material and a nitric oxide donor that coat the bismuth sulfide nanorods. The high polymer material is polyoxyethylene sorbitan laurate Tween-20, and the nitric oxide donor includes BNN (bis-N-nitroso compound). Themetal sulfide nanomaterial can convert light energy into heat, and utilizes the photothermal conversion process to promote the nitric oxide donor to decompose and release nitric oxide, also controlledrelease of nitric oxide and photothermal therapy can realized simultaneously, nitric oxide can reduce the self-protection effect of tumor cells during thermal therapy and significantly improve the tumor treatment effect. Therefore, the metal sulfide nanomaterial provided by the invention overcomes the disadvantages of the traditional tumor thermotherapy method, and is suitable for tumor treatmentwith complex needs.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a metal sulfide nanomaterial and its preparation method and application. Background technique [0002] Since nitric oxide (NO) was rated as the star molecule of the year by Science magazine in 1992, a series of studies on NO have been carried out. Researchers have found that NO can act as a messenger molecule in organisms and play an extremely important role in various physiological regulation processes, such as neurotransmission, vasodilation, hormone secretion, platelet aggregation, damage repair, immune regulation, etc. Clinically, nitric oxide donor drugs are commonly used in the treatment of sudden angina pectoris and coronary heart disease. [0003] At present, the commonly used donors that can release NO mainly include the following categories: sodium nitroprusside, nitric acid / nitrite, S-nitrosothiol, and N-azoenediols. The common feature of these wide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00A61K33/00
CPCA61K33/00A61K41/0052A61K2300/00
Inventor 谷战军张潇董兴华赵宇亮
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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