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Preparation and application of a squid ink melanin chelated calcium tablet

A technology for ink melanin and melanin, which is applied in the field of preparation and application of squid ink melanin chelated calcium tablets, can solve the problems of easy moisture absorption and deterioration, poor taste, affecting quality, etc., and achieves good stability, controllable quality, and production. Process feasible effect

Active Publication Date: 2020-07-24
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are a lot of methods about the preparation technology of calcium tablet, and prior art is the Chinese invention patent of CN 103356496 B as authorized public number, discloses a kind of calcium citrate malate medicine tablet, and this invention method will citrate malate Calcium raw material powder is directly compressed to obtain tablets, which have the characteristics of high solubility, high absorption and utilization, no influence on the absorption of iron by the human body, safety and non-toxicity, and will not destroy the acid-base balance of the gastrointestinal tract, but it only uses citrate Calcium malate is used as a tablet, resulting in no sweetness and poor taste in the tablet, and the tablet does not have any coating material, which makes it easy to absorb moisture and deteriorate, affecting quality

Method used

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  • Preparation and application of a squid ink melanin chelated calcium tablet

Examples

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Effect test

Embodiment 1

[0019] A kind of preparation and application of squid ink melanin chelated calcium tablet comprises the following steps:

[0020] 1) Take the squid and get the ink, soak it in an equal volume of pure water at 4°C overnight, centrifuge at 11,000r / min for 10 minutes, add alkaline protease to hydrolyze, then heat up to inactivate the enzyme, centrifuge at 12,000r / min for 10 minutes, wash repeatedly, and centrifuge until neutral , take the precipitate and dry it at 65°C to obtain melanin; 2) add neutral protease and flavor enzyme to the squid meat to hydrolyze and inactivate, and filter to obtain the hydrolyzate; take 1ml 0.1mol / L ferric chloride solution and add it to 100ml hydrolyze Add 0.1 g of ascorbic acid to the solution, adjust the pH to 7, and the temperature to 20°C, magnetic stirring for chelation for 15 minutes, centrifugation to remove the precipitate, concentration, freeze-drying, and storage in a desiccator at 0°C for later use; 3) Pipette 9 mmol / L Calcium chloride ...

Embodiment 2

[0023] A preparation and application of a squid ink melanin chelated calcium tablet, comprising: obtaining ink melanin, preparation of polypeptide chelated iron, chelation, tablet preparation, and application, specifically including the following steps:

[0024] 1) Obtain ink melanin: cut open the abdomen of the squid, take out the ink sac, cut open the sac, squeeze out the ink, soak in 4°C equal volume of pure water overnight, centrifuge at 12000r / min for 25 minutes, adjust the pH to 7.5, and the temperature to 55°C, add alkaline protease 4500U / g, then add 0.5% of the ink weight 4-hydroxyphenylethanol, hydrolyze for 2 hours, then heat up to inactivate the enzyme, centrifuge at 14000r / min for 15 minutes, wash repeatedly, centrifuge until neutral, and take the precipitate The product is dried at 75°C to obtain melanin; enzymatic extraction of squid ink melanin has a good hydrolysis effect, is simple and easy to operate, avoids the use of toxic organic solvents, is environmentall...

Embodiment 3

[0029] A preparation and application of squid ink melanin chelated calcium tablet, comprising: obtaining ink melanin, preparation of polypeptide chelated iron, preparation of polypeptide chelated calcium, tablet preparation and application, specifically including the following steps:

[0030] Obtain ink melanin: cut open the abdomen of squid, take out the ink sac, cut the sac membrane, squeeze out the ink, soak in 2°C equal volume of pure water overnight, centrifuge at 12000r / min for 15 minutes, adjust the pH to 7.4, and the temperature to 52°C , add alkaline protease 4200U / g, then add 0.7% of ink weight 4-hydroxyphenylethanol, hydrolyze for 3 hours, then raise the temperature to inactivate the enzyme, centrifuge at 14000r / min for 15 minutes, repeatedly wash with water, centrifuge until neutral, take the precipitate in Dried at 70°C to obtain melanin; enzymatic extraction of squid ink melanin has a good hydrolysis effect, simple operation, avoids the use of toxic organic solven...

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Abstract

The invention discloses a preparation method of a squid ink melanin chelated calcium tablet. The preparation method comprises the following steps: obtaining ink melanin, preparing polypeptide chelatediron, preparing polypeptide chelated calcium, and preparing the tablet. The squid ink melanin chelated calcium tablet can be swallowed, chewed or sublingually taken, and is suitable for people of multiple age groups to eat. The tablet has the following advantages: effective calcium components in the tablet have a high content and can be easily absorbed by human bodies, and the ink melanin has antibacterial and antiviral activities, and also has strong oxidation prevention and free radical removal effects, so the tablet can enhance the immunity of human bodies; the calcium tablet has excellentmouthfeel, a good stability and a strong disintegration effectiveness, so the dissolve-out of medicines is accelerated; the production method is feasible, the quality is controllable, and the production method is suitable for industrial large-scale production; and the tablet can enhance the body immunity through adjusting the stable state of an anti-oxidation system while supplementing calcium, has a certain excreting effect on blood lead and liver lead, and also has a protection effect ton copper in the liver, zinc in the kidney and zinc in the brain.

Description

technical field [0001] The invention relates to the field of preparation and application of tablets, in particular to the preparation and application of a squid ink melanin chelated calcium tablet. [0002] technical background [0003] Calcium is an essential element for living things. For the human body, Ca is available in muscles, nerves, body fluids and bones 2+ bound protein. Calcium is the main inorganic component of human bones and teeth, and is also an essential element for nerve transmission, muscle contraction, blood clotting, hormone release and milk secretion. Calcium is involved in metabolism, and calcium must be supplemented every day; insufficient or excess calcium in the human body will affect growth and health. Calcium is the most abundant element of inorganic salts in the human body. The total amount of calcium in the body of a healthy adult is about 1000-1300 grams, accounting for about 1.5%-2.0% of the body weight, and 99% of the calcium exists in the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/618A61K9/20A61P3/14A61P37/04A61K33/06
CPCA61K9/2059A61K33/06A61K35/618A61K2300/00
Inventor 俞群娣
Owner ZHEJIANG OCEAN UNIV
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