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Method for improving biomimetic mineralization capacity of surface of titanium alloy implant

A biomimetic mineralization, titanium alloy technology, applied in the direction of prosthesis, pharmaceutical formulation, drug delivery, etc., can solve the problem of not obtaining a nanometer surface layer, and achieve the effect of easily controlling repeatability, maintaining dimensional accuracy and surface roughness

Active Publication Date: 2018-05-18
ANHUI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Huang Run et al. published the article "The Effect of Surface Mechanical Grinding on the Bioactivity of Medical Titanium Alloys" on pages 522-529, Vol. The TLM alloy was treated with SMAT for 30 minutes. The treated TLM alloy significantly changed the surface roughness, topological structure, hydrophilicity and the content of oxygen elements in different chemical states on the surface of the alloy, showing stronger biological activity, but the TLM titanium alloy The phase composition and grain size have not changed, and a nano-sized surface layer with good osteogenic effect has not been obtained

Method used

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  • Method for improving biomimetic mineralization capacity of surface of titanium alloy implant
  • Method for improving biomimetic mineralization capacity of surface of titanium alloy implant
  • Method for improving biomimetic mineralization capacity of surface of titanium alloy implant

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Effect test

Embodiment 1

[0038] This embodiment provides a method for improving the biomimetic mineralization ability of the titanium alloy implant surface, the specific steps are:

[0039] The sample is the TLM titanium alloy hot-rolled plate after vacuum smelting. The hot-rolled plate is cut into discs with a diameter of 100 mm and a thickness of 5 mm. #, 1200# water sandpaper grinding, surface polishing, ultrasonic cleaning with acetone and deionized water, drying, using the SNC-I type metal material surface nanometer test jointly manufactured by the Institute of Metal Research, Chinese Academy of Sciences and Chengdu New Crystal Technology Co., Ltd. The above-mentioned polished TLM wafers were SMAT treated by the machine. The treatment process was carried out under normal temperature and pressure. The impact balls used 50 GCr15 steel balls with a diameter of 5mm, the working frequency was 200Hz, and the vacuum was pumped to 3 As the ion source, the P ions used are selected by a symmetrical double-f...

Embodiment 2

[0052] This embodiment provides a method for improving the biomimetic mineralization ability of the titanium alloy implant surface, the specific steps are:

[0053] The sample is the TLM titanium alloy hot-rolled plate after vacuum smelting. The hot-rolled plate is cut into discs with a diameter of 100 mm and a thickness of 5 mm. #, 1200# water sandpaper grinding, surface polishing, ultrasonic cleaning with acetone and deionized water, drying, using the SNC-I type metal material surface nanometer test jointly manufactured by the Institute of Metal Research, Chinese Academy of Sciences and Chengdu New Crystal Technology Co., Ltd. The above-mentioned polished TLM wafers were SMAT treated by the machine. The treatment process was carried out under normal temperature and pressure. The impact balls used 50 GCr15 steel balls with a diameter of 2mm, the working frequency was 500Hz, and the vacuum was pumped to 3 As the ion source, the P ions used are selected by a symmetrical double-f...

Embodiment 3

[0055] This embodiment provides a method for improving the biomimetic mineralization ability of the titanium alloy implant surface, the specific steps are:

[0056] The sample is the TLM titanium alloy hot-rolled plate after vacuum smelting. The hot-rolled plate is cut into discs with a diameter of 100 mm and a thickness of 5 mm. #, 1200# water sandpaper grinding, surface polishing, ultrasonic cleaning with acetone and deionized water, drying, using the SNC-I type metal material surface nanometer test jointly manufactured by the Institute of Metal Research, Chinese Academy of Sciences and Chengdu New Crystal Technology Co., Ltd. The above-mentioned polished TLM wafers were SMAT treated by the machine. The treatment process was carried out under normal temperature and pressure. The impact balls used 50 GCr15 steel balls with a diameter of 8mm, the working frequency was 100Hz, and the vacuum was pumped to 17 ions / cm 2 , the injection beam density is 55μA / cm 2 .

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Abstract

The invention discloses a method for improving biomimetic mineralization capacity of the surface of a titanium alloy implant. According to the method, after the surface of the titanium alloy implant is subjected to mechanical grinding treatment, a nanocrystallized surface layer is produced, P ions are injected into the nanocrystallized surface layer with an ion injection technology, the injectioneffect is enhanced due to presence of more dislocation and other defects on the nanocrystallized implant surface, and injected ion concentration is increased three times or more than that of an implant without surface nanocrystallization; globular apatite is fully distributed on the surface of the implant after 28 days of soaking with simulated body fluid, and accordingly, biological activity of the titanium alloy implant is obviously improved.

Description

technical field [0001] The invention belongs to a method for modifying the surface of a titanium alloy implant, in particular to a method for improving the bionic mineralization ability of the surface of a titanium alloy implant. Background technique [0002] Titanium alloy has ideal physical and chemical properties and good biocompatibility. It is a clinical artificial implant material with good application prospects. Since it has no osteoinductive activity, it cannot form sufficient chemical combination with surrounding bone tissue. make clinical application limited. The chemical composition and structure of hydroxyapatite is similar to that of bone tissue, and it can combine with bone tissue through chemical bonds and induce new bone formation. Therefore, the use of hydroxyapatite coating method has become one of the commonly used modification methods for the surface of titanium alloys. [0003] At present, the methods for preparing HA thin films from titanium alloys ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/32A61L27/50C23C14/48C23C14/02
CPCA61L27/06A61L27/32A61L27/50A61L2400/12A61L2400/18A61L2420/02C23C14/021C23C14/028C23C14/48
Inventor 黄润秦亮黄雷黄明策
Owner ANHUI UNIV OF SCI & TECH
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