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Medical chitosan-carboxymethyl chitosan crosslinked sponge and preparation method thereof

A technology of carboxymethyl chitosan medicine and carboxymethyl chitosan is applied in the field of chitosan carboxymethyl chitosan medical cross-linked sponge and its preparation, and can solve the problem of carboxymethyl chitosan cross-linking, The problem of powder filler falling off, to achieve the effect of promoting wound healing, preventing tissue adhesion, and moderate degradation speed

Active Publication Date: 2018-05-18
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a small amount of chitosan powder or chitin powder added is insoluble in water, so it cannot be cross-linked with carboxymethyl chitosan, and the powder therein only acts as a filler. The filler is easy to fall off from the sponge void, which has certain limitations

Method used

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  • Medical chitosan-carboxymethyl chitosan crosslinked sponge and preparation method thereof
  • Medical chitosan-carboxymethyl chitosan crosslinked sponge and preparation method thereof
  • Medical chitosan-carboxymethyl chitosan crosslinked sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Dissolve CS in 1% (volume ratio) acetic acid solution to prepare 2 L of CS solution with a mass percent content of 1 mg / ml. The viscosity-average molecular weight of chitosan is 650,000.

[0057] The carboxymethyl chitosan was dissolved with deionized water, and stirred rapidly to obtain a uniform 3% carboxymethyl chitosan (CMC) solution.

[0058] Take 60 g of 3% carboxymethyl chitosan solution, add 0.5 g of 3% sodium bicarbonate solution therein, and then make the mixed solution continue to stir under strong mechanical stirring.

[0059] Take 30g of 1% chitosan solution and slowly add it to the mixed solution of CMC, then add 1.4g of 13% calcium chloride solution to the final mixed solution, stir rapidly to make it cross-linked completely.

[0060] Finally, neutralize with an appropriate amount of sodium hydroxide solution to a pH of about 7.3. Take the above-mentioned gel-like substance in a container, and freeze-dry to obtain the desired CS / CMC cross-linked sponge. ...

Embodiment 2

[0066] The influence of embodiment 2CS molecular weight on CS / CMC crosslinked sponge color

[0067] Referring to the method of Example 1, the concentration and degradation time of CS were changed (Scheme 1-7) to prepare CS / CMC cross-linked sponge:

[0068]

[0069] 1) Table 3 shows the composition and browning degree of CS / CMC crosslinked sponge prepared by crosslinking CS with the same concentration of CMC at different concentrations and degradation times, Image 6 Apparent morphology of CS / CMC crosslinked sponges prepared for different compositions. in, Image 6 (A), (B), (C) are respectively 5g 0.5% CS solution (molecular weight 650,000), 5g 0.75% CS solution (molecular weight 650,000) and 5g 1% CS solution (molecular weight 650,000) respectively 10g 3%CMC (Undegraded) Apparent morphology of CS / CMC sponge prepared by crosslinking. Image 6 (D) CS / CMC sponge prepared by cross-linking 10g 1% CS (molecular weight is 500,000) and 20g 3% CMC (undegraded); Image 6 (E) CS / ...

Embodiment 3

[0078] The density measurement of embodiment 3CS / CMC cross-linked sponge

[0079] Place the prepared cylindrical sponge in an oven at 43°C for 48 hours and take it out to measure its radius and thickness to obtain its volume. Weigh to obtain mass, calculate the density ρ of CS / CMC cross-linked sponge by formula (I).

[0080] ρ=M / (πr 2 d) (I)

[0081] In the formula: M—mass of dry sponge; r—radius of sponge; d—thickness of sponge

[0082] According to the interpretation of the relevant national departments, the density is ≥ 45kg / cm 3 The ones are high-density, with a density of 45-18kg / cm 3 Between medium density, density 3 for low density. The higher the density of the sponge, the smaller the voids inside and the greater the quality. High-density sponge has many holes and is very full. It is often used as sound-absorbing cotton, sofa cushions, soft bags and other materials; medium-density and low-density sponges are used as general protective materials. Generally speaki...

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Abstract

The invention relates to medical chitosan-carboxymethyl chitosan crosslinked sponge and a preparation method thereof. The method comprises steps as follows: chitosan is dissolved in an acetic acid water solution, a basic solution is prepared, ozone is introduced during stirring for degradation, and a degraded chitosan solution is obtained; carboxymethyl chitosan is dissolved in water, and a carboxymethyl chitosan solution is prepared; a sodium bicarbonate solution is added to the carboxymethyl chitosan solution, and the mixture is subjected to strong mechanical stirring to be mixed uniformly;the chitosan solution is added to the obtained mixed solution, the mixture is mixed uniformly, a calcium chloride solution is added, and the mixture is rapidly stirred for a crosslinking reaction; a sodium hydroxide solution is added, the pH is regulated, a gelatinous substance is taken out and freeze-dried, and the medical chitosan-carboxymethyl chitosan crosslinked sponge is obtained. The medical chitosan-carboxymethyl chitosan crosslinked sponge has good mechanical strength, good moisture absorption, moisture retention and hemostasis properties as well as moderate degradation speed, is notprone to discoloration, can promote wound healing and prevent tissue adhesion and can rapidly absorb wound secretions or water in blood.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to a chitosan carboxymethyl chitosan medical cross-linked sponge and a preparation method thereof. Background technique [0002] The crosslinking of biological materials can be carried out by physical crosslinking methods such as ultraviolet radiation, photooxidation and severe dehydration, and chemical crosslinking methods such as genipin, glutaraldehyde, carbodiimide and polyepoxides can also be used. Chemical crosslinking by reagents. Glutaraldehyde is the first and most commonly used cross-linking agent. It has the advantages of bifunctionality, water solubility and low price. Cytotoxicity, tissue hardening and calcification. Genipin is a new type of cross-linking agent, but it also has certain toxicity (Wang Min, Da Lincui, Xie Yan, et al. Application of genipin as a cross-linking agent in the modification of natural biomaterials. China Rest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08J9/28C08L5/08C08B37/08A61L24/08A61L24/00
CPCA61L24/001A61L24/0015A61L24/0036A61L24/0042A61L24/08A61L2400/04C08B37/003C08J3/246C08J9/28C08J2305/08C08J2405/08C08L5/08
Inventor 张春雷李经华
Owner JINAN UNIVERSITY
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