Hydrophobic double-coating microcapsule and preparation method thereof

Abstract

The invention discloses a hydrophobic double-coating microcapsule and a preparation method thereof. The hydrophobic double-coating microcapsule comprises a water-soluble microcapsule core and an enteric-soluble hydrophobic layer coating on the outer surface of the water-soluble microcapsule core. The weight ratio of the water-soluble microcapsule core and the hydrophobic layer is 1:0.05-0.1. The beneficial effect of the hydrophobic double-coating microcapsule is that the hydrophobic double-coating microcapsule is capable of effectively embedding active ingredients of a core material, and preventing the core material from being migrated and oxidized, thereby improving the stability of the microcapsule, and the hydrophobic double-coating microcapsule has the good dissolution rate in an enteric solubility environment, and is beneficial for the biological absorption.

Description

technical field [0001] The invention relates to microcapsules, in particular to a water-repellent double-coated microcapsule and a preparation method thereof. Background technique [0002] Microencapsulation technology refers to the technology of embedding solids, liquids or gases in tiny and sealed capsules so that they can only be released under specific conditions; among them, the embedded material is called the core material, and the embedded core material The material that achieves microencapsulation is called wall material. Microencapsulation methods are divided into chemical method, physical chemical method and physical method, and people can choose the appropriate method according to their needs; the spray drying method in the physical method is currently the most commonly used and cheapest microencapsulation method. The product prepared by spray drying method has good dispersibility and solubility, simple production process and convenient operation, but there are c...

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Problems solved by technology

[0003] The common practice of domestic manufacturers to prepare water-dispersible microcapsules into water-repellent microcapsules is to use partition heating crosslinking; however, the partition heating crosslinking method has uneven heating, and the microcapsule shell is easy to rub off during the crosslinking process , The core material migrates to the surface of the microcapsules through the gaps in the shell; the above problems will lead to poor product quality, such as irregular particles, poor fluidity, and poor surface oil indicators, which will affect the product microencapsulation yield and product shelf life.

[0004] In view of this, low-temperature multi-coating spray technology has also been studied; for example, in the sixth issue of "China Food Additives" in 2011, "Application Research of Condensation Spray Drying in Microencapsulated Carotenoids", Zhou Di et al. The application of double-coating technology is mentioned; starch is used as the secondary coating wall material, which is also a common method for double-coating at present; As a result, in the later stage of cross-linking, the core material will easily migrate from the inside to the outside to the shell of the microcapsules and be oxidized and damaged, causing the surface oil of the microcapsules to remain high, as much as 30%, and the stability of the product is poor

[0005] The Chinese patent with the publication number CN103549157A discloses a method for preparing water-repellent microcapsules; the preparation method includes adding protein active enzymes to the emulsion, granulating, cross-linking, and drying to obtain water-repellent microcapsules; the microcapsules are determined to The water-repellent cross-linking reaction occurs in the inner layer and the surface layer of the whole particle, and the microcapsules are dense; the microcapsules obtained by this preparation method have certain enteric solubility, but the dissolution rate in animal intestinal fluid is poor, which affects the dissolution of the core material speed, which in turn affects its absorption

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