Hydrotalcite tablet and preparation method thereof

Abstract

The invention discloses a hydrotalcite tablet and a preparation method thereof. The hydrotalcite tablet is prepared from the following components by weight percent: 45 to 65 percent of hydrotalcite, 25 to 43 percent of filling agent, 8.6 to 12 percent of disintegrating agent, 0.3 to 0.5 percent of corrigent and 0.5 to 2.5 percent of lubricating agent, wherein the filling agent consists of a sugar-alcohol filling agent and an inorganic salt filling agent; and the disintegrating agent is a combination of microcrystalline cellulose and low substituted hydroxypropyl methyl cellulose or a combination of microcrystalline cellulose and cross-linked carboxymethylcellulose sodium. The hydrotalcite tablet has the characteristics of rapidness in disintegration, high acid generation capacity, and longacting time; and moreover, no special auxiliary material is needed, the preparation method is simple, no special equipment is needed, the production cost is low, and the hydrotalcite tablet is suitable for the industrialized production.

Description

technical field [0001] The invention belongs to the field of pharmacy, and more specifically, the invention relates to a hydrotalcite tablet which can be rapidly disintegrated, has strong antacidity and long-lasting effect and a preparation method thereof. Background technique [0002] The chemical name of Aluminum Magnesium Carbonate is Hexadecyl Dialuminum Carbonate Hexamagnesium Tetrahydrate. It is a water-insoluble crystalline powder with a layered network structure. It is not absorbed by the gastrointestinal tract after oral administration, but is absorbed in the esophagus, stomach, ten The duodenal mucosa forms a multilayer network lattice structure, which is deposited on the surface of the mucosa to exert its function. Aluminum carbonate has the following pharmacological effects: ①Neutralization of gastric acid: 1g of aluminum carbonate can neutralize 27.1mmol-27.8mmol of hydrochloric acid to generate two insoluble salts, water and carbon dioxide, which can neutralize...

AI Technical Summary

Problems solved by technology

However, the test results show that the antacid effect of the tablets prepared by this scheme varies greatly, and some of them are even lower than the standard requirement of 260ml; Chinese patent application CN200710093165.8 discloses a aluminum magnesium carbonate tablet and its preparation process , this scheme micronizes the main drug, and then adopts wet granulation and spray granulation. The process is complicated, which increases the difficulty of industrial production, and the onset time of the preparation is still about 10 minutes, which is relatively long; Chinese patent ZL201210001044.7 discloses a aluminum magnesium carbonate tablet. In this solution, sodium lauryl sulfate is added to promote disintegration, and the antacid power and antacid effect maintenance time are improved by adding a weak acid pH regulator, but this solution The raw materials need to be micronized, which is costly, and during the research process, the inventors found that the tablets prepared by this solution would increase gas generation during acid neutralization, aggravating abdominal distension caused by gas retention; Chinese patent ZL201010584531.1 discloses A hydrotalcite tablet and a preparation method thereof are disclosed. In this scheme, microcrystalline cellulose and cross-linked sodium carboxymethyl starch are used as disintegrants, and the powder is directly compressed into tablets. Although the scheme obtains disintegration faster preparations, but the antacid power and maintenance time are still not ideal

[0005] It can be seen that the current improved methods of hydrotalcite tablets have not yet been able to meet the needs of rapid disintegration, strong antacidity and long duration of action.

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