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Application of motherwort in preparation of medicine for treating gouty arthritis
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A technology of gouty arthritis and motherwort, which is applied in the field of traditional Chinese medicine to achieve the effect of no toxic and side effects, relieving gouty arthritis, and safe use
Inactive Publication Date: 2019-10-25
WUHAN UNIV
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Abstract
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Problems solved by technology
Whether leonurine can alleviate MSU crystal-induced gouty arthritis by improving the AA network has not been reported so far
Method used
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Embodiment 1
[0028] [Example 1] Leonurine is used to prepare tablets for the treatment of gouty arthritis
[0029] Mix 12.5g of motherwortine with 35g of dextrin and 65% ethanol to make a soft material, pass through an 80-mesh nylon sieve to granulate, dry at 70-80°C for 30 minutes, pass through a 20-mesh iron sieve for granulation, and 60-mesh iron sieve to remove fines. Powder, add 1.5g magnesiumstearate, 1g talcum powder and mix, tabletting, make 500 tablets.
Embodiment 2
[0030] [Example 2] Leonurine is used to prepare capsules for the treatment of gouty arthritis
[0031] Mix 75g of motherwortine with 220g of starch, moisten with 15% ethanol, mix into a paste, pass through a 100-mesh nylon sieve to granulate, dry under vacuum for 1 hour at 80°C, pass through a 60-80-mesh iron sieve for granulation, add 6g of hard Magnesiumfatty acid is mixed, and capsules are made into 1000 capsules.
Embodiment 3
[0032] [Example 3] Leonurine is used to prepare chewable tablets for the treatment of gouty arthritis
[0033] Take 100g of motherwort, powder it into a fine powder, add 30g of sodiumstarch glycolate, 25g of aspartame, and 345g of xylitol, mix well, granulate with 75% ethanol, dry, mix well, and press into tablets to make a tablet weighing 1g chewable tablets.
[0034] The preparation method of leonurine of the present invention and its pharmaceutical composition of various dosage forms, the pharmacology that it selects allows commonly used adjuvant material can be one or more in the following types:
[0035] Stabilizers: such as cyclodextrin inclusion complexes, surfactants (anionic surfactants, cationic surfactants, zwitterionic surfactants, nonionic surfactants).
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Abstract
The invention discloses application of leonurine to preparation of a medicine for treating gouty arthritis. The leonurine serves as an effective component and is used for preparing tablets, capsules,chewable tablets and other useable administration dosage forms. The obtained medicine has good effect on gouty arthritis caused by the fact that sodium urate crystals are deposited at joints and the periphery, so that pain is eliminated and the advantages of simplicity and convenience in operation, good effect and no toxic or side effect are achieved.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicinepharmacy, and relates to the application of a specific monomerleonurine in Chinese herbal medicineMotherwort in the preparation of medicine for treating gouty arthritis. Background technique [0002] Acute gout is an ancient form of arthritis characterized by inflammation usually occurring in the first metatarsophalangeal joint. In the past two decades, the incidence of gout has increased at an alarming rate, especially in the elderly population. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the first-line drugs for the treatment of gouty arthritis, but their clinical application has been greatly limited due to unavoidable gastrointestinal or cardiovascular adverse reactions (Scheiman JM ., 2016; MarsicoF, et al., 2017). Therefore, the development of drugs for the treatment of gouty arthritis is a hot spot in current gout research. [0003] Gouty arthritis is caused by ...
Claims
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Application Information
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