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3D printing based degradation-controllable bone tissue engineering scaffold and preparation method

A technology of bone tissue engineering and 3D printing, applied in the field of biomedical materials, can solve the problems such as the inability to guarantee the precise design and manufacture of the microporous structure, the inability to achieve the degradation speed of the implant, and the inability to combine and assemble different materials, and achieve optimal material utilization. It is beneficial to the interaction of nutrients and the effect of good economic benefits.

Inactive Publication Date: 2018-06-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention is to provide a degradable and controllable bone tissue engineering scaffold based on 3D printing, which solves the problem that the bone defect repair materials in the prior art cannot guarantee the precise design and manufacture of the microporous structure, and cannot combine and assemble different materials. The problem of inability to effectively control the degradation rate of implants

Method used

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  • 3D printing based degradation-controllable bone tissue engineering scaffold and preparation method
  • 3D printing based degradation-controllable bone tissue engineering scaffold and preparation method
  • 3D printing based degradation-controllable bone tissue engineering scaffold and preparation method

Examples

Experimental program
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Embodiment 1

[0036] This embodiment provides the preparation of degradable and controllable bone tissue engineering scaffolds, specifically:

[0037]Take hydroxyapatite (HA) as raw material 1, tricalcium phosphate powder (β-TCP) as raw material 2, and mix raw material 1 and raw material 2 uniformly at a mass ratio of 60:40 to obtain a mixed powder. Take 10g of polyvinyl alcohol, add 90ml of water to dissolve, and prepare a polyvinyl alcohol solution. Mix 20ml of polyvinyl alcohol solution evenly into 32.5g of mixed powder, add 7ml of deionized water and 6ml of absolute ethanol while stirring, until the mixture is evenly stirred to obtain printing ink raw materials. Wherein, the powder particle diameters of hydroxyapatite and tricalcium phosphate are both 50 nm to 100 μm.

[0038] In the modeling software, a 10mm × 10mm × 3mm cube was established, and then combined with the layering software to perform layered slicing processing on the built model, setting the diameter of the printing mate...

Embodiment 2

[0041] This example provides the preparation of degradable and controllable bone tissue engineering scaffold. The modeling and sintering process of the bracket in this embodiment are the same as in Embodiment 1, the difference is that the configuration of 3D printing ink raw materials is carried out in a different batching method from that in Embodiment 1, specifically:

[0042] Take 10g of polyvinyl alcohol, add 90ml of water to dissolve, and prepare a polyvinyl alcohol solution. 20ml of polyvinyl alcohol solution was uniformly added to 32.5g of hydroxyapatite (HA), and while stirring, 7ml of deionized water and 6ml of absolute ethanol were added until the mixture was evenly stirred to obtain printing ink raw materials. Wherein, the particle size of the hydroxyapatite powder is 50 nm to 100 μm.

[0043] Then, the model in Example 1 was 3D printed and sintered into porcelain to obtain the HA ceramic bone tissue engineering scaffold. The degradation rate of the stent in this ...

Embodiment 3

[0045] This example provides the preparation of degradable and controllable bone tissue engineering scaffold. The modeling and sintering process of the bracket in this embodiment are the same as in Embodiment 1, the difference is that the configuration of 3D printing ink raw materials is carried out in a different batching method from that in Embodiment 1, specifically:

[0046] Take 10g of polyvinyl alcohol, add 90ml of water to dissolve, and prepare a polyvinyl alcohol solution. 20ml of polyvinyl alcohol solution was uniformly added to 32.5g of tricalcium phosphate (β-TCP), and while stirring, 7ml of deionized water and 6ml of absolute ethanol were added until the mixture was evenly stirred to obtain printing ink raw materials. The particle size of tricalcium phosphate powder is 50nm-100μm.

[0047] Then, the model in Example 1 was 3D printed and sintered into porcelain to obtain the β-TCP ceramic bone tissue engineering scaffold. The degradation rate of the scaffold in th...

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Abstract

The invention discloses a 3D printing based degradation-controllable bone tissue engineering scaffold and a preparation method thereof and solves the problems that precise design and manufacture of amicroporous structure cannot be guaranteed by a bone defect repairing material and the material degradation speed cannot be regulated effectively in the prior art. The scaffold is of a porous structure, porosity is 60%-95%, wire diameter of a pore wall support material is 100-800 mu m, and the scaffold is prepared from an ink raw material layer by layer by printing or prepared from at least two different ink raw materials in a layered manner by printing. The method comprises the following steps: preparing the ink raw material for 3D printing; establishing a model, performing hierarchical slicing on the established model, inputting the designed 3D model into a 3D jet printer, performing layer-by-layer printing to precisely form a target green body, and calcining the green body to obtain degradation-controllable bioceramic. By means of the degradation-controllable bone tissue engineering scaffold, combination and assembly of materials with different degradation speeds in 3D space can berealized, precise design forming of the microporous structure can be guaranteed, and the material degradation speed is regulated effectively.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a 3D printing-based degradation-controllable bone tissue engineering scaffold and a preparation method. Background technique [0002] Bone defect repair materials have always been one of the research hotspots in the field of biomaterials. As a special biomaterial, bone tissue repair materials have special functional requirements: mechanical properties under load, biocompatibility, osteoconductivity and osteoinductivity. In recent years, due to the many advantages of degradable artificial bone tissue engineering repair materials, it has gradually become the development direction of bone repair materials. Bioactive calcium phosphate ceramics containing CaO and P 2 o 5 These two components are important inorganic substances that constitute human bone tissue. After being implanted into the human body, their surface can be combined with human tissue to achi...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/58A61L27/12B33Y10/00B33Y80/00
Inventor 周长春樊渝江张勃庆孙勇裴玄李慧勇蒋青张兴栋
Owner SICHUAN UNIV
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