Highly-soluble sulbenicillin sodium colon-targeted starch capsule and preparation method thereof

Abstract

The invention provides a highly-soluble sulbenicillin sodium colon-targeted starch capsule and a preparation method thereof. According to the invention, a starch capsule is used and is filled with sulbenicillin sodium, the nested part of a capsule shell is sealed with a sealing material so as to prepare a hard capsule, and the prepared hard capsule is coated with a colon-soluble coating solution;and the colon-soluble coating solution is prepared by mixing a coating material, a coating solvent and a plasticizer. The invention has the following advantages: the prepared highly-soluble sulbenicillin sodium colon-targeted starch capsule has the triple effects of colon targeting performance, rapid disintegration and slow drug release, prolongs the circulation time of oral sulbenicillin sodium in the body and improves the absorption efficiency of sulbenicillin sodium; compared with the prior art where special colon-soluble capsule shells are selected, the highly-soluble sulbenicillin sodiumcolon-targeted starch capsule of the invention is high in filling percentage, and a coating process adopted in the invention is stable in process, easy to operate and suitable for large-scale industrial production; after coating, the starch hard capsule prepared by using the method can maintain the color and transparency of the original capsule and improve patient compliance; and the preparation method does not need special equipment, and is simple in process, easy to operate and low in cost.

Description

technical field [0001] The invention relates to a highly soluble sulbenicillin sodium colon-targeting starch capsule and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Sulbenicillin sodium belongs to broad-spectrum semi-synthetic penicillin antibiotics. It is effective against the following infections caused by sensitive bacteria such as Pseudomonas aeruginosa, Proteus, and E. coli: (1) Respiratory system infections, such as acute and chronic bronchitis, bronchiectasis, bronchial Pneumonia, pneumonia, etc.; (2) abdominal infection, such as peritonitis, cholecystitis, cholangitis, etc.; (3) urinary system infection, such as pyelonephritis, cystitis, urethritis, etc.; (4) gynecological infection, such as uterine appendages (5) superficial suppurative diseases, such as folliculitis, cellulitis, tonsillitis, postoperative wound infection, traumatic or burn infection, etc.; (6) sepsis; (7) subacute Bacterial endocarditis...

AI Technical Summary

Problems solved by technology

However, these methods are more or less flawed. The pH value type material is alkaline and degrades with the pH. After entering the intestinal environment, the pH value from the front of the small intestine to the colon gradually increases, and the alkaline material is not at the pH of the colon. Only when the condition begins to dissolve, but before reaching the colon, most of the pH value type materials are not dissolved, and a small part of the material dissolves, but the rupture of some membrane layers may lead to a large amount of sudden release of the drug

However, the use of colonic bacteria degradable materials may also cause the instability of release due to individual differences and differences in bacterial flora.