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Application of water-soluble fullerene structure for preparing medicine for treating fatty liver

A water-soluble, fullerene technology, applied in the field of medicine, can solve the problem that the mechanism of fatty liver is not completely clear

Inactive Publication Date: 2018-06-26
BEIJING FUNAKANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of fatty liver has not yet been fully elucidated

Method used

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  • Application of water-soluble fullerene structure for preparing medicine for treating fatty liver
  • Application of water-soluble fullerene structure for preparing medicine for treating fatty liver
  • Application of water-soluble fullerene structure for preparing medicine for treating fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1. Preparation of water-soluble hydroxylated fullerene structure

[0069] Weigh 100mg C 60 solid or 100mg C 70 Solid or 100mg Gd@C 82 Solid, 7ml of 30% hydrogen peroxide, 3ml of 10% sodium hydroxide solution, react at 50 ° C until the powder is completely dissolved, then washed with ethanol, dialyzed to obtain the corresponding hydroxylated derivative, namely water-soluble fullerene structure.

[0070] 3ml of the 10% sodium hydroxide solution was replaced with a certain amount of 30% ammonia water, and the other steps were carried out according to the above method to obtain the corresponding aminated derivative, that is, the water-soluble fullerene structure.

[0071] The hydroxylated derivative or aminated derivative obtained after dialysis contains a lot of liquid, and it can also be concentrated to obtain a solid, but whether the concentration is carried out or not, the water solubility of the raw material fullerene / the raw material embedded metallofullere...

Embodiment 2

[0073] To the C prepared in above-mentioned embodiment 1 70 The corresponding hydroxylated derivatives (hereinafter referred to as C 70 -OH) for elemental analysis (Flash EA 1112), and the number of hydroxyl groups attached to it was analyzed in combination with the results of thermogravimetric and derivative thermogravimetric analysis. In the results of elemental analysis, the C 70 In -OH, the C content is 37.85%, the H content is 1.51%, and the N content is figure 1 Thermogravimetric analysis shows that C 70 The -OH solid powder contains 3.7% water, which is about 5 water molecules. Combined with the ratio of H content to C content in elemental analysis, it can be estimated that 24 hydroxyl groups are modified on the surface of the carbon cage. so C 70 The average structural formula of -OH is C 70 (OH) 24 ·5H 2 O.

[0074] For the Gd@C prepared in Example 1 above 82 The corresponding hydroxylated derivatives (hereinafter referred to as Gd@C 82 (OH) n ) for elementa...

Embodiment 3

[0075] Example 3. Water-soluble embedded metallofullerene Gd@C 82 (OH) n Free radical scavenging ability test

[0076] The present invention detects water-soluble endometallofullerene Gd@C by electron spin resonance spectroscopy (ESR). 82 (OH) n Ability to scavenge free radicals.

[0077] Detection method: Using the method of UV-induced hydroxyl radical generation, 50 μL of hydrogen peroxide with a mass concentration of 39%, 50 μL of PBS buffer solution (pH=7.4) and a trace (0.133 mM) of lutidine N-oxide (DMPO, free The control group was directly irradiated with ultraviolet light, while the experimental group immediately added 20 μL of the water-soluble endometallofullerene aqueous solution prepared according to the method in Example 1, 10 μL, and irradiated with 280 nm ultraviolet light for 4 min respectively. free radical signal. as attached figure 2 As shown, the non-smooth line is not adding the water-soluble intercalated metallofullerene Gd@C obtained according to ...

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Abstract

The invention discloses a water-soluble fullerene structure for preparing a medicine for treating fatty liver, and discloses a pharmaceutical composition and a method for treating fatty liver. Activeingredients for treating fatty liver are water-soluble fullerene, water-soluble inlaid metal fullerene, composition of the water-soluble fullerene and the water-soluble inlaid metal fullerene, and pharmaceuitical ester of above three and pharmaceutical salt of the three. The active ingredient water-soluble fullerene structure can reduce fatty vesicles in the liver, lower blood lipids, and obviously improve liver function, so that the content of alanine aminotransferase and aspartate aminotransferase tends to be normal, and the effect of treating fatty liver is highly effective. The active ingredient water-soluble fullerene structure can also regulate the level of redox in the liver.

Description

[0001] The present invention requires that Beijing Funakang Biotechnology Co., Ltd. and the Institute of Chemistry, Chinese Academy of Sciences, submitted to the Chinese Patent Office on December 19, 2016, the application number is CN201611180067.3, and the invention name is "water-soluble fullerene structure in the preparation of therapeutic Priority of the Chinese Patent Application for "Use in Medicines for Fatty Liver", the entire contents of which are incorporated herein by reference. technical field [0002] The invention relates to the field of medicine, in particular to the application of a water-soluble fullerene structure in preparing a medicine for treating fatty liver. Background technique [0003] Fatty liver disease (ie, fatty liver) is a pathological process in which excessive fat accumulation in liver cells can be caused by a variety of incentives. It is also a pathological process in the development of various liver diseases. It is the most common diffuse liv...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61K47/54A61P1/16A61P3/04A61P3/06A61P3/10
CPCA61K33/44A61K47/54A61P1/16A61P3/04A61P3/06A61P3/10
Inventor 王春儒李雪甄明明周辰白春礼
Owner BEIJING FUNAKANG BIOTECH CO LTD
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