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Method for preparing responsive polymer/Fe3O4 hybrid nano-hydrogel

A nano-hydrogel and polymer technology, which is applied in the field of preparation of responsive polymer/Fe3O4 hybrid nano-hydrogel, can solve the problem of poor biocompatibility of matrix polymer, affecting the response ability of matrix polymer, miscellaneous Chemical nanohydrogels do not have problems such as degradability

Active Publication Date: 2018-11-13
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the hybrid nano-hydrogels reported in the above studies can reflect magnetic, thermal synergy or multiple response capabilities such as magnetism, heat and pH, the inventors have found that there are still certain defects: (1) in the above-mentioned hybrid nano-hydrogels , Fe 3 o 4 The particles are compounded with the polymer matrix in a simple physical embedding method, so their structural stability is not high, especially after redispersing in the water system, Fe is prone to appear. 3 o 4 Particles are separated from the matrix polymer; (2) Due to the use of ordinary free radical polymerization, the crosslinked structure formed by the matrix polymer is not uniform, which affects the responsiveness of the matrix polymer to a certain extent; (3) Matrix polymerization The biocompatibility of the material is not good, and the hybrid nanohydrogel is not degradable

Method used

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  • Method for preparing responsive polymer/Fe3O4 hybrid nano-hydrogel
  • Method for preparing responsive polymer/Fe3O4 hybrid nano-hydrogel
  • Method for preparing responsive polymer/Fe3O4 hybrid nano-hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Weigh 0.6g of lipophilic emulsifier Span-80 and 0.4g of hydrophilic emulsifier Tween-60, and dissolve them in 10g of cyclohexane to obtain an emulsifier solution.

[0050] 0.45 g of vinyl-surface-modified Fe 3 o 4 Nanoparticles [10nm, coupling density 1.0μmol·(m 2 Fe 3 o 4 ) -1 】Pre-dispersed in 2g water to get Fe 3 o 4 Aqueous dispersion of nanoparticles; then to Fe 3 o 4 Add 0.05g of NaBF to the aqueous dispersion of nanoparticles 4 , 0.8g N-vinyl caprolactam, 0.2g acrylate-2-methoxyethyl ester, 0.05g polyethylene glycol dimethacrylate (the number average molecular weight is 550g mol -1 ) and 0.01 g of RAFT reagent 2-(dodecyltrithiocarbonate)-2-methylpropanoic acid to obtain Fe 3 o 4 Polar dispersion of nanoparticles; subsequently 0.005 g of initiator 2,2’-azobisisobutylamidine dihydrochloride was added to the polar dispersion; the emulsifier solution was poured into Fe 3 o 4 In the polar dispersion liquid, the coarse emulsion is obtained by pre-emulsific...

Embodiment 2

[0054] Weigh 0.24g emulsifier ethylene-butylene copolymer-polyoxyethylene block copolymer [P(E / B)-PEO], the preparation method of this block copolymer is found in literature [Langmuir 2003,19,4455-4459 .], dissolved in 30 g of isoparaffin (isopar M, Exxon Mobil), to obtain an emulsifier solution.

[0055] 0.15 g of vinyl-modified Fe 3 o 4 Nanoparticles [15nm, the coupling density of vinyl is 1.8μmol·(m 2 Fe 3 o 4 ) -1 】Pre-dispersed in 2g water to get Fe 3 o 4 Aqueous dispersion of nanoparticles; then to Fe 3 o 4 Add 0.12 g of Na to the aqueous dispersion of nanoparticles 2 SO 4 , 0.5g methacrylic acid, 0.1g 2-methoxyethyl acrylate, 0.05g N,N'-bis(acryloyl)cystamine and 0.05g RAFT reagent 4-((2-carboxyethyl)tri Thiocarbonate)-4-cyanoglutaric acid to give Fe 3 o 4 Polar dispersion of nanoparticles; subsequently 0.02 g of initiator azobiscyanovaleric acid was added to the polar dispersion; the emulsifier solution was poured into Fe 3 o 4 In the polar dispersion li...

Embodiment 3

[0059] Weigh 3g of lipophilic emulsifier Span-80 and 2g of hydrophilic emulsifier MOA-9, and dissolve them in 100g of n-hexadecane to obtain an emulsifier solution.

[0060] 0.67g vinyl surface modified Fe 3 o 4 Nanoparticles [20nm, coupling density 1.0μmol·(m 2 Fe 3 o 4 ) -1 】Pre-dispersed in 13g water to get Fe 3 o 4 Aqueous dispersion of nanoparticles, and then to Fe 3 o 4 The aqueous dispersion of nanoparticles adds 1.0g of NaCl, 4g of N-vinyl caprolactam, 1.3g of polyethylene glycol methacrylate (the number average molecular weight is 500gmol -1 ), 0.16 g of N,N'-bis(acryloyl)cystamine and 0.16 g of RAFT reagent 4-cyano-4-(thiobenzoyl)valeric acid to obtain Fe 3 o 4 Polar dispersion of nanoparticles; pour emulsifier solution into Fe 3 o 4In the polar dispersion liquid, the coarse emulsion was obtained by pre-emulsification; then the container containing the coarse emulsion was placed in an ice-water bath, and ultrasonically treated at a power of 300W for 10 mi...

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Abstract

The invention discloses a method for preparing responsive polymer / Fe3O4 hybrid nano-hydrogel. The method has the advantages that high-biocompatibility vinyl compounds are used as monomers, high-biocompatibility or degradable divinyl compounds are used as cross-linking agents, Fe3O4 particles with vinyl-modified surfaces are used as functional inorganic components, and accordingly the degradable responsive polymer / Fe3O4 hybrid nano-hydrogel which is good in biocompatibility, excellent in structural stability and has multiple-response capability can be prepared in inverse miniemulsion systems bythe aid of active / controllable RAFT (reversible addition fragmentation chain) polymerization and grafting reaction of the surfaces of the Fe3O4 particles.

Description

(1) Technical field [0001] The present invention relates to a responsive polymer / Fe 3 o 4 Preparation method of hybrid nano hydrogel. (2) Background technology [0002] The molecular chains of responsive polymers can respond responsively to changes in environmental conditions, which has made responsive polymers an important candidate for building smart materials. Responsive hybrid nanohydrogels with environment-responsive hydrophilic polymers as the polymer network skeleton and functional inorganic nanoparticles as the dispersed phase can not only produce significant physical and chemical responses to small changes in the external environment, but also have a series of The expected optical, magnetic, and catalytic properties have important application values ​​in high-end fields such as biology, medicine, catalysis, and disease detection and treatment. They are especially suitable as nanocarriers for drugs and targeted therapy for diseases. Polymer / Fe 3 o 4 Hybrid nanoh...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F226/06C08F220/28C08F290/06C08F220/06C08F220/34C08F220/54C08F226/10C08F220/20C08F222/38
CPCC08F290/062C08F292/00C08F220/281C08F220/34
Inventor 曹志海高峰吴鑫磊王懿婷秘一芳戚栋明
Owner ZHEJIANG SCI-TECH UNIV
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