Nutrient preparation used for elderly patients with swallowing dysfunction

A technology for nutritional preparations and swallowing function, which is applied in the field of diet for special medical purposes, can solve the problems of changes in food viscoelasticity, poor absorption, and reduced viscosity, and achieves the effect of reducing diarrhea and improving colonization rate.

Active Publication Date: 2018-12-07
WUXI PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Currently commercially available enteral nutrition preparations are mostly used for infusion routes such as nasogastric tubes and jejunostomy, have low viscosity, are not suitable for elderly patients to take orally, and have the following deficiencies: (1) such as Nengli, Ruisu, Whole protein enteral nutrition preparations such as Ruigao use high-energy, high-density proteins such as casein, which are likely to cause allergies or indigestion, and poor absorption; (2) starch-based food thickeners are mostly used Protein, carrageenan, gum or other combination with starch
Due to the presence of salivary amylase in the human oral cavity, the starch in the food bolus will be decomposed, causing a rapid decrease in viscosity and changing the viscoelasticity of the food; in addition, the starch granule solution absorbs water and swells, and its physical properties have great temperature dependence and time. Dependence, which will cause the fluid viscosity of starch-thickened food at different temperatures or different preparation times to be very different from the initial preparation viscosity, resulting in the viscosity and rheological properties of the actually obtained nutritional preparations not meeting the requirements;( 3) The existing nutritional preparations lack ingredients and dietary fiber that are beneficial to the intestinal microecology, and are prone to abdominal distension, diarrhea and poor absorption

Method used

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  • Nutrient preparation used for elderly patients with swallowing dysfunction
  • Nutrient preparation used for elderly patients with swallowing dysfunction
  • Nutrient preparation used for elderly patients with swallowing dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, the influence of chitosan degree of deacetylation and dosage on the fluid properties of nutritional preparations

[0027] The nutritional preparation was prepared according to the following composition: 10 parts of protein, 20 parts of fat, 40 parts of carbohydrate, 3 parts of chitosan, 1 part of chitooligosaccharide, 0.1 part of Acetobacter pasteurianus CGMCC No.12930, 0.1 part of Lactobacillus rhamnosus LGG part, 0.1 part of bifidobacteria, and 5 parts of mannose oligosaccharides.

[0028] The protein is soybean polypeptide; the fat is corn oil microcapsule powder; and the carbohydrate is corn starch. Choose chitosan with different degrees of deacetylation, respectively 80%, 85%, 90%, and 95%, to prepare four nutritional preparations. The molecular weight of the chitosan oligosaccharide is less than 3000, and the total amount of chitobiose-chitohexaose is more than 80%. The Acetobacter pasteurianus CGMCC No.12930 was deposited on September 5, 2016 in t...

Embodiment 2

[0044] Embodiment 2, the promoting effect of the invention scheme on the survival and colonization of probiotics

[0045] Prepare two kinds of oral nutritional preparations with the method provided by the scheme of the present invention, the difference is that A does not add chitosan and mannose oligosaccharides.

[0046] The formula of nutritional preparation A: 10 parts of protein, 20 parts of fat, 40 parts of carbohydrate, 3 parts of chitosan, 0.01 part of Acetobacter pasteurianus CGMCC No.12930, 0.1 part of Lactobacillus rhamnosus LGG, 0.01 part of Bifidobacterium .

[0047] The formula of nutritional preparation B: 10 parts of protein, 20 parts of fat, 40 parts of carbohydrate, 3 parts of chitosan, 1 part of chitooligosaccharide, 0.01 part of Acetobacter pasteurianus CGMCC No.12930, 0.1 part of Lactobacillus rhamnosus LGG , 0.01 part of bifidobacterium, 1 part of mannose oligosaccharide.

[0048] 20 hospitalized elderly patients were recruited, divided into two groups, ...

Embodiment 3

[0053] Embodiment 3, the influence of inventive scheme on nutrition, immunity, neurological function of elderly patients

[0054] Prepare two kinds of oral nutritional preparations A and B with the method provided by the scheme of the present invention, the difference is that the thickener selected by group A is starch and carrageenan, and the thickener selected by group B is chitosan and chitosan oligosaccharide, and the formula is as follows :

[0055] A: 12 parts of protein, 25 parts of fat, 45 parts of carbohydrate, 3 parts of starch, 1 part of carrageenan, 0.1 part of Acetobacter pasteurianus CGMCC No.12930, 0.1 part of Lactobacillus rhamnosus LGG, 0.1 part of Bifidobacterium , 3 parts of mannose oligosaccharides.

[0056] B: 12 ​​parts of protein, 25 parts of fat, 45 parts of carbohydrates, 3 parts of chitosan, 1 part of chitosan oligosaccharide, 0.1 part of Acetobacter pasteurianus CGMCC No.12930, 0.1 part of Lactobacillus rhamnosus LGG, bifidus 0.1 part of Bacillus, ...

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Abstract

The present invention discloses a liquid oral enteral nutrient preparation containing chitosan, probiotics and dietary fibers. The preparation is suitable for elderly patients with swallowing dysfunction, has proper initial viscosity, has resistance to salivary amylase, has fluidics property change due to the appropriate shearing in the swallowing process, and significantly reduces the occurrencerate of misinhalation to lung and vomiting for the patients with swallowing dysfunction; and the preparation is fine in taste and easy to absorb, helps to repair intestinal barrier, and can obviouslyimprove nutrition, immunity and nerve functions of elderly patients. The nutrient preparation disclosed by the invention comprises the following components in parts by weight: nutrient substances: 10-15 parts of proteins, 20-30 parts of fat and 40-50 parts of carbohydrate; thickeners: 1-5 parts of chitosan and 1-5 parts of chitosan oligosaccharide; probiotics: 0.01-0.1 part of acetobacter pasteurianus CGMCC No.12930, 0.01-0.1 part of lactobacillus rhamnosus LGG, and 0.01-0.1 part of bifidobacterium; and other ingredients: 1-5 parts of mannan-oligosaccharide.

Description

technical field [0001] The invention relates to the field of meals for special medical purposes, in particular to a nutritional preparation suitable for elderly patients with swallowing dysfunction and its preparation and application method. Background technique [0002] Swallowing dysfunction refers to the difficulties and obstacles in the process of swallowing and transporting solid / liquid food, saliva, drugs, etc. from the mouth to the stomach. Age group, especially the elderly, especially those suffering from neurodegenerative diseases and stroke. 60-80% of patients with neurodegenerative diseases and more than 30% of stroke patients suffer from swallowing dysfunction. 10-30% of people aged 65-70, and 40% of people over 70 years old suffer from swallowing dysfunction. Dysphagia can easily lead to loss of appetite, malnutrition, dehydration, and electrolyte dysfunction in patients, which will increase the possibility of inhalation of food into the trachea when swallowin...

Claims

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Application Information

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IPC IPC(8): A23L33/00A23L33/135A23L29/20A23L29/30A61K35/745A61K35/747A61K35/741A61P1/00A61P37/04A61K31/702
CPCA61P1/00A61P37/04A23L29/20A23L29/30A23L33/135A23L33/40A61K31/702A61K35/741A61K35/745A61K35/747A23V2002/00A23V2400/175A23V2400/51A23V2200/30A23V2200/324A23V2200/322A23V2200/3204A23V2200/242A23V2250/28A23V2250/511A23V2250/54252A23V2250/55A23V2250/5118A23V2250/5114A23V2250/5116A61K2300/00
Inventor 陆守荣钱建瑛
Owner WUXI PEOPLES HOSPITAL
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