Method for preparing renewable magnesium-based bone material with Mg/TiO2-HA gradient porous coating

Abstract

The invention relates to a method for preparing a renewable magnesium-based bone material with an Mg / TiO2-HA gradient porous coating for bone implantation and belongs to the field of medical materials. The renewable magnesium-based bone material with an Mg / TiO2-HA gradient porous coating comprises a Ti02 / Ag-HA gradient porous coating and a magnesium-based bone material and the Ti02 / Ag-HA gradientporous coating coats the magnesium-based bone material. Printing materials used by the experiment are divided into two groups, the first group comprises Mg particle and Ag powder mixed powder as a metal powder base and the second group comprises multiple gradient coating powder obtained by mixing Mg, TiO2 and HA materials according to a strict ratio. The method comprises: constructing a 3D printing model, carrying out printing and carrying out post-treatment after cladding. The porous coating has high bonding strength, is degradable and antibacterial, greatly improves cell adhesion, proliferation and the production of new blood vessels, significantly improves biological activity and biocompatibility and achieves bone regenerability.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a preparation method of a renewable magnesium-based bone material implanted with a Mg / TiO2-HA gradient porous coating. Background technique [0002] The purpose of human beings' research on biomedical materials is to make devices made of these materials replace or repair human organs and tissues and realize their physiological functions. When biological materials are in long-term or temporary contact with the human body, they must fully meet the compatibility with the biological environment, that is, the organism does not undergo any biological reactions such as toxicity, sensitization, inflammation, carcinogenesis, and thrombus, which all depend on the surface of the material. Interactions of organisms with their environment. Therefore, controlling and improving the surface properties of biomaterials is a key way to exert and utilize the favorable conditions between materials a...

AI Technical Summary

Problems solved by technology

However, this method also has some disadvantages: it is a linear process, and it is difficult to make a uniform coating on porous or complex-shaped substrates; the original material needs to be high-purity HA powder, which is expensive; the temperature in the preparation process is high, When cooling, there will be a high residual stress at the interface between the substrate and the coating; the high temperature process of spraying will cause the decomposition of HA, resulting in the formation of impurity phases in the coating, and the low crystallinity of HA, etc.

[0004] The invention with the patent number CN201610211779.0 provides a 3D printed titanium and titanium alloy bone-like porous bone product and its preparation method. The method uses 3D printing technology to prepare porous titanium and titanium alloy bone products. The surface is directly In contact with the human body, the porous design improves biocompatibility and effectively weakens or eliminates stress shielding, but titanium and titanium alloys are expensive, have low biological activity, and have single functions

Images