Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of oligoacetylamino sugar acid and selective oxidation preparation method

A polyacetylamino sugar acid and selective technology, which is applied in the field of oligomer acetylamino sugar acid and selective oxidation preparation, can solve the problems of few reaction sites, low yield, slow reaction and the like, and achieves good hydrophilicity, Apply a wide range of effects

Active Publication Date: 2021-06-18
INST OF PROCESS ENG CHINESE ACAD OF SCI +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, due to the hydrogen bonding within and between molecules of chitin, it has high crystallinity, dense texture, and insoluble in water, resulting in fewer reaction sites, slow reaction, and low yield.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A selective oxidation preparation method of oligoacetylamino sugar acid, the steps are as follows:

[0024] The flaky chitin from prawns was processed to 0.5mm pieces with a pulverizer. Mix the hydrochloric acid solution with a mass concentration of 7% and 5g of chitin fragments at a liquid-to-solid ratio of 10:1, put them into a hydrolysis reactor, and react at 120°C for 45 minutes. Filter the solid and wash it until it is dried with neutral hot air to obtain low molecular weight chitin for later use. Mix 50g of calcium chloride, 24ml of deionized water and 100ml of anhydrous methanol to form a calcium chloride methanol solution. The standby low molecular weight chitin was dissolved in calcium chloride methanol solution, and after 6 hours, the regenerated chitin was precipitated with deionized water. After drying at 60°C, 4.5 g of low molecular weight regenerated chitin powder was obtained.

[0025] Add the aqueous low-molecular-weight regenerated chitin (equivalent...

Embodiment 2

[0028] A selective oxidation preparation method of oligoacetylamino sugar acid, the steps are as follows:

[0029] Take 10g of chitin from crab shells, crush it to 0.3mm, mix it with 8% sulfuric acid solution at a liquid-solid ratio of 12:1, and heat it to 150°C in a hydrolysis reactor for 60 minutes. After naturally cooling to room temperature, the solid was filtered, washed and dried with neutral hot air to obtain low molecular weight chitin. 3 g of them were dissolved in the calcium chloride methanol solution described in Example 1 to finally obtain 2.7 g (dry weight) of low molecular weight regenerated chitin.

[0030] Weigh 1g of water-containing low molecular weight regenerated chitin equivalent to dry weight and add it to 20ml of deionized water, then add 15mg of TEMPO, 0.4g of NaBr and 30ml of NaClO reagent, adjust the reaction solution to pH=9~10, stir at room temperature and electromagnetically for 6 hours, stop reaction. The reaction product was precipitated with ...

Embodiment 3

[0032] The selective oxidation preparation method of oligoacetylamino sugar acid, the steps are as follows:

[0033] (1) Process the flaky chitin to 0.5mm fragments with a pulverizer, mix the hydrochloric acid solution with a mass concentration of 5% and 5g chitin fragments at a liquid-solid ratio of 8:1, put them into a hydrolysis reaction kettle, and heat them at 170°C. React for 90 minutes; filter the solid and wash until dried with neutral hot air to obtain low molecular weight chitin for later use;

[0034] (2) Mix calcium chloride, anhydrous methanol and deionized water to prepare a calcium chloride methanol solution with a calcium chloride molar concentration of 3.5M, and the water content is 1.5 times the molar number of calcium chloride. Molecular weight chitin is dissolved in calcium chloride methanol solution, the mass concentration of chitin is 3%, after 6 hours of normal temperature treatment, the regenerated chitin is precipitated with deionized water, and the lo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
degree of polymerizationaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of oligoacetaminoglycemic acid and selective oxidation. The molecular weight of the oligoacetaminoglycine is 500-7000, the degree of polymerization n is 2-32, the structural formula is as follows: and the preparation method is as follows: Firstly, the raw material chitin is made to be less than 0.5 mm, and the low molecular weight regenerated chitin is prepared in acid solution and calcium chloride methanol solution. Secondly, TEMPO, sodium bromide and sodium hypochlorite are used as oxidizing agents to oxidize the carbon 6 hydroxyl group of chitin to carboxyl group at room temperature to obtain water-soluble oligoacetylamino sugar acid. The preparation method of the invention has mild reaction conditions, suitable reaction time and high yield. Oligoacetylamino sugar acid has good hydrophilicity, moisture retention, biocompatibility and plant-inducing activity, etc., and can be used as a ligand to form a variety of functional products, and is widely used in medicine, food, agriculture and other fields.

Description

technical field [0001] The invention relates to the field of biopolymers, in particular to an oligoacetylamino sugar acid and a selective oxidation preparation method. Background technique [0002] Chitin exists in large quantities in crustaceans - such as shrimp, sea crab, crayfish and so on. Chitin is the second largest natural organic substance except cellulose in nature, and it is a biomass resource widely used in medicine, food, agriculture and other fields. Chitin is a long-chain polymer formed on the basis of N-acetylglucosamine. Its fibrous structure has a crystalline phase region and an amorphous phase region, so it is insoluble in water and has certain limitations in application. [0003] Enhancing water solubility is an important measure to improve its application. The current general water-solubility enhancement process is mainly to prepare chitin into chitosan. Chitosan is the product of deacetylation of chitin, which forms a positively charged polyelectrolyt...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
CPCC08B37/003
Inventor 王威王宝群刘京玲
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI