Hydroxyapatite porous support and preparation method thereof

A technology of hydroxyapatite and porous scaffolds, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of manual operation, uncontrollable pore size, poor repeatability, etc., and achieve the goal of improving mechanical strength and benefiting cell proliferation Effect

Active Publication Date: 2019-01-01
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of traditional porous scaffolds has the disadvantages of needing to add a large amount of pore-for

Method used

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  • Hydroxyapatite porous support and preparation method thereof
  • Hydroxyapatite porous support and preparation method thereof
  • Hydroxyapatite porous support and preparation method thereof

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preparation example Construction

[0038] The preparation method of strontium-doped octacalcium phosphate of the present invention is:

[0039] (1) prepare strontium acetate solution;

[0040] (2) prepare ammonium dihydrogen phosphate and urea solution;

[0041] (3) Add the strontium acetate solution in step (1) dropwise to the ammonium dihydrogen phosphate and urea solution in step (2), stir for 2 hours at 90°C, wash and dry to obtain the strontium-doped Octacalcium Phosphate.

[0042] The preparation method of strontium-doped amorphous calcium phosphate of the present invention is:

[0043] (a) preparing a mixed solution of calcium nitrate and strontium nitrate, wherein the concentration of calcium nitrate in the mixed solution is 0.25M;

[0044] (b) preparing a sodium silicate solution with a concentration of 0.25M;

[0045] (c) Add the mixed solution of calcium nitrate and strontium nitrate in step (a) into the sodium silicate solution in step (b) while stirring, after stirring for 30-60min, age for 4-6...

Embodiment 1

[0047] As an embodiment of the preparation method of the hydroxyapatite porous scaffold described in the present invention, the preparation method of the hydroxyapatite porous scaffold described in this embodiment includes the following steps:

[0048] (1) Mix and grind hydroxyapatite, strontium-doped octacalcium phosphate and strontium-doped calcium silicate in a mass ratio of 70:8:22 to obtain a solid phase powder, wherein the hydroxyapatite, strontium-doped phosphoric acid The particle size of octacalcium phosphate and strontium-doped amorphous calcium phosphate is 20-50 μm, and the molar ratio of strontium and calcium in the strontium-doped octacalcium phosphate and strontium-doped amorphous calcium phosphate is both 0.1;

[0049] (2) dissolving carboxymethyl chitosan and silk fibroin in water, stirring evenly to obtain a mixed solution, wherein, the mass fraction of carboxymethyl chitosan in the mixed solution is 1%, and the mass fraction of silk fibroin is The score is 1...

Embodiment 2

[0054] As an embodiment of the preparation method of the hydroxyapatite porous scaffold described in the present invention, the preparation method of the hydroxyapatite porous scaffold described in this embodiment includes the following steps:

[0055] (1) Mix and grind hydroxyapatite, strontium-doped octacalcium phosphate and strontium-doped calcium silicate in a mass ratio of 70:5:25 to obtain a solid phase powder, wherein the hydroxyapatite, strontium-doped phosphoric acid The particle size of octacalcium phosphate and strontium-doped amorphous calcium phosphate is 150-200 μm, and the molar ratio of strontium to calcium in the strontium-doped octacalcium phosphate and strontium-doped amorphous calcium phosphate is both 0.1;

[0056] (2) Carboxymethyl chitosan and silk fibroin are dissolved in water, stirred evenly to obtain a mixed solution, wherein, the mass fraction of carboxymethyl chitosan in the mixed solution is 1.5%, and the mass fraction of silk fibroin is The score...

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Abstract

The invention discloses a hydroxyapatite porous support and a preparation method thereof. The preparation method comprises the following steps: mixing solid powder comprising hydroxyapatite, strontium-doped octacalcium phosphate and strontium-doped calcium silicate and a solution comprising carboxymethyl chitosan and silk fibroin, freezing to form orientation ice crystals, sublimating the ice crystals under the freeze drying effect, in-situ forming orientated layered macropores in a material after the ice crystals are sublimated, wherein the porous structure is high in communication performance, and the silk fibroin can provide attachment sites for the growth of cells, so that the growth of the bone-forming cells can be facilitated, and an effect for inducing the bone formation can be achieved; and the carboxymethyl chitosan and the silk fibroin form an intersected network structure with hydroxyapatite, strontium-doped octacalcium phosphate and strontium-doped calcium silicate, so thatthe mechanical strength of the support can be further improved.

Description

technical field [0001] The invention relates to the technical field of bone repair materials, in particular to a porous hydroxyapatite scaffold and a preparation method thereof. Background technique [0002] Bone is an important tissue of the human body. Although it has bone regeneration and self-repair capabilities, for bone defects caused by tumors, trauma, and abnormal bone growth, in the case that bone self-repair alone cannot heal, it is necessary to use implant materials to assist the damage. Tissue repair and healing. From the perspective of bone tissue self-healing, an ideal bone repair scaffold needs to have good biocompatibility, biodegradability, three-dimensional porous structure, and a complex shape that matches the defect site. The porous bone repair scaffold has a high specific surface area and space, which is conducive to the loading of active factors, cell adhesion and growth, deposition of extracellular matrix, entry of nutrients and oxygen, discharge of m...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/54A61L27/56
CPCA61L27/425A61L27/54A61L27/56A61L2300/102A61L2300/412A61L2300/604A61L2430/02C08L5/08C08L89/00
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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