Method for preparing iron-based bone implant capable of accelerating degradation

Abstract

The invention relates to a method for preparing iron-based bone implant capable of accelerating degradation. The method comprises the following steps: (1) ball milling to break a wall; (2) acidification treatment; (3) filtration and drying; (4) powder dispersion; (5) Laser sintering. The invention has the beneficial effect that the end of the carbon nanotube generates structural defects by utilizing a ball milling wall-breaking process, Carboxyl and hydroxyl functional group are formed at that structural defect through acidification treatment, The Coulomb adsorption between iron and iron ionsis used to adsorb the bivalent and trivalent iron ions produced by the degradation of iron matrix, so as to avoid the production of ferric hydroxide, ferrous hydroxide and other degradation products covering on the iron matrix, to promote the full contact between the iron matrix and human body fluid, and to accelerate the degradation process of iron-based bone implants; At that same time, the carboxyl and hydroxyl functional group in the invention can further accelerate the degradation of the iron-based bone implant by improving the hydrophilicity of the iron-based bone implant.

Description

technical field [0001] The invention belongs to the technical field of metal bone implants, in particular to a preparation method of an iron-based bone implant capable of accelerating degradation. Background technique [0002] Existing orthopedic implants, such as stainless steel, titanium-based alloys, nickel-based alloys and other inert metal materials, require a second operation to remove them after completing the bone repair task in the human body, which brings great physiological pain and economic burden to patients . Iron is a metal material that is easily corroded in the atmosphere and seawater. Therefore, iron-based alloys need to be treated for corrosion protection in engineering and structural applications, but this corrosion characteristic happens to meet the needs of biodegradable materials. Coupled with their excellent comprehensive properties and biocompatibility, iron-based alloys have gradually attracted widespread attention from researchers and clinicians i...

AI Technical Summary

Problems solved by technology

[0003] However, as a degradable bone implant material, iron faces the problem of too slow degradation in vivo, which does not match the recovery rate of bone tissue

Studies have shown that when iron is implanted in the body, only a slight corrosion occurs on the surface, and it often remains in the body after the bone tissue heals, which limits its clinical application in orthopedics.

For this reason, people seek to develop new degradable iron-based alloys through alloying. Although this improves the degradation rate of iron to a certain extent, it is still difficult to meet the requirements of degradable bone implants.

[0004] The main reason for the slow degradation of iron in the body is the products formed by its degradation. These degradation products include ferric hydroxide, ferrous hydroxide, ferric oxide, ferrous oxide and ferric carbonate. Accumulation on the iron matrix hinders the further contact of body fluids with the iron matrix, resulting in faster degradation in the early stage of implantation and slower degradation in the middle and late stages