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Oral quick-disintegrating cardiac emergency tablet and its 3D printing method and application
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An oral rapid disintegration, 3D printing technology, applied in cardiovascular system diseases, pharmaceutical formulations, medical preparations with inactive ingredients, etc., to achieve the effects of simple preparation process, good therapeutic effect, and high market application prospects
Active Publication Date: 2021-10-08
XIAN DI JIA BIOTECH CO LTD
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[0006] The purpose of the present invention is to provide oral rapid disintegrating heart disease first aid tablet for the treatment of myocardial infarction and its 3D printing method, aiming to solve the problem of drug loading, production process and problems with taste
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[0074] Note: The amount of each component added in the prescription is based on the current amount ± 0.1g.
[0075] (2) 3D printing process
[0076] Except following conditions, other is all identical with embodiment 1:
[0077] ①Aspirinraw material and sorbitol are passed through a 150-mesh sieve before weighing; 1% starch solution is used as a binder; the single-layer powder is 0.5mm high, and the single-layer liquid is sprayed twice, and the number of layers is 60; single tablet The consumption of binding agent described in is 0.3 times of medicine powder weight;
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Abstract
The invention discloses an oral rapid disintegration heart diseasefirst aid tablet and its 3D printing method and application. The oral rapid disintegration heart diseasefirst aid tablet is made of pharmaceutical grade raw powder and binder through 3D printing; wherein the pharmaceutical grade The raw powder includes one or more raw materials such as aspirin and auxiliary materials. Through the selection of the components and ratio of the orally rapidly disintegrating cardiac emergency tablet, the drug loading, hardness and disintegration time of the drug can be effectively controlled, and the drug can be made It has a good taste when taken. The preparation process of the 3D printing method is simple and easy to implement, and the prepared orally rapidly disintegrating heart attackfirst aid tablet has a porous water-soluble matrix, which can be quickly dissolved in water, and the disintegration time is 5 to 60 seconds. The application of aspirin single or compound in heart diseaseemergency treatment such as myocardial infarction can effectively save life-saving time for patients in case of sudden illness, and has extremely high practicability and wide application prospects.
Description
technical field [0001] The invention relates to the field of 3D preparation of medicines, in particular to an oral rapid disintegration cardiac emergency tablet for treating myocardial infarction and its 3D printing method and use. Background technique [0002] Aspirin is a non-steroidal antipyretic, analgesic and anti-inflammatory drug, and has antithrombotic effect. It inhibits the synthesis of thromboxane by inhibiting the activity of cyclooxygenase in platelets, so as to achieve the anticoagulant effect and avoid the occurrence of thrombus. At present, aspirin is mostly used in the field of anti-inflammatory and analgesic, and there is no report that aspirin is made into an oral rapid disintegration cardiac emergency tablet with a large drug load through 3D printing and applied in the field of treating sudden cardiac diseases such as myocardial infarction. [0003] Ticagrelor is an anticoagulant drug belonging to cyclopentyltriazole pyrimidines. It has a series of advant...
Claims
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