Method for preparing taurine

A technology of taurine and sodium isethionate, applied in the fields of sulfonic acid preparation, sulfonate preparation, organic chemistry, etc., can solve the problems of harsh conditions of ammonolysis reaction, inability to fully apply the mother liquor, and high energy consumption in the reaction process , to achieve the effects of improving electrophilic properties, shortening reaction time, and mild reaction temperature and pressure conditions

Inactive Publication Date: 2019-03-19
WANHUA CHEM GRP CO LTD
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  • Abstract
  • Description
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Problems solved by technology

[0005] The key synthesis step of the ethylene oxide method is the reaction of sodium isethionate and liquid ammonia to prepare sodium taurine. In the initial research, since no catalyst was added, harsh conditions of high temperature of 200-280°C and high pressure of 14-21MPa were required. Reaction conditions, which have resulted in high energy consumption in the reaction process and higher production costs
[0006] Chinese patent CN105732440A discloses that in the ammonolysis reaction process containing mother liquor, alkali metal hydroxides, alkali metal carbonates (including acid carbonates), iron series / aluminum series metal salts, NiO / CeO can be added 2 , rare earth oxides or any combination thereof as a catalyst, the yield of sodium taurate can be increased to 90-95%, but the reaction still requires a high temperature of 255-265°C and a pressure of 19-20MPa, and the conditions are still relatively harsh
[0009] In summary, the ammonolysis reaction conditions of the current taurine preparation process are still relatively harsh, and the mother liquor cannot be completely applied in the process of mechanical application due to the addition reaction to produce ethylene glycol and other by-products. Therefore, the process conditions need to be improved. Reduce energy consumption in the production process, reduce production costs, increase the amount of mother liquor, and increase the yield of taurine products

Method used

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  • Method for preparing taurine

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Effect test

Embodiment 1

[0046] Put 2808.8g of 25wt% sodium bisulfite solution in a 10L reactor, maintain the temperature in the reactor at 25°C, and add 7g of Sn-beta catalyst into the reactor, mix well, and then slowly feed 300g of epoxy into the reactor Ethane, after passing through ethylene oxide, continue to react for 15min, take a sample and analyze, the yield of this step reaction is 99.5%; Add a certain amount of pure water in the reactor subsequently, reduce the concentration of sodium isethionate in the system Dilute to around 15.0wt%, then feed a certain amount of liquid ammonia to make the concentration of liquid ammonia reach 24.0wt%, then add 1.0g (0.1wt%) NaBiO 3 Catalyst and 1.0g CuCl co-catalyst, the temperature of the reaction system was raised to 160° C., the system pressure was 9.8 MPa, and the reaction was carried out for 30 minutes. The yield of sodium taurate obtained by the ammonolysis reaction was 92.5%. After the reaction solution was flashed at 100°C to remove ammonia, it wa...

Embodiment 2

[0048] 2006.3g 35wt% sodium bisulfite solution is placed in a 10L reactor, and the temperature in the reactor is maintained at 40°C, and 10.5g of Sn-beta catalyst is added in the reactor, mixed evenly, and then 300g of rings are slowly introduced into the reactor. Oxygen, after passing through ethylene oxide, continue to react for 30min, take a sample and analyze, the yield of this step reaction is 99.7%; then add a certain amount of pure water in the reactor, and sodium isethionate in the system Dilute the concentration to around 15.0wt%, then pass a certain amount of liquid ammonia to make the concentration of liquid ammonia reach 21.0wt%, then add 2.0g (0.2wt%) NH 4 BiO 3 Catalyst and 1.0g CuCl co-catalyst, the reaction system was heated to 140°C, the system pressure was 7.2MPa, and the reaction was carried out for 20min. The yield of sodium taurate obtained in this step was 89.0%. After the reaction solution was flashed at 100°C to remove ammonia, it was evaporated and co...

Embodiment 3

[0050] Place 2340.6g 30wt% sodium bisulfite solution in a 10L reactor, maintain the temperature in the reactor at 30°C, and add 17.5g of Sn-beta catalyst in the reactor, mix well, then slowly feed 300g ring Oxygen, after passing through ethylene oxide, continue to react for 30min, take a sample and analyze, the yield of this step reaction is 99.4%; then add a certain amount of pure water in the reaction kettle, the sodium isethionate in the system Dilute the concentration to around 15.0wt%, then feed a certain amount of liquid ammonia to make the concentration of liquid ammonia reach 18.0wt%, then add 0.5g (0.05wt%) LiBiO 3 Catalyst and 0.4g CuCl co-catalyst, the reaction system was heated to 120° C., the system pressure was 5.1 MPa, and the reaction was carried out for 60 minutes. The yield of sodium taurate obtained in this step reaction was 95.0%. After the reaction solution was flashed at 100°C to remove ammonia, it was evaporated and concentrated to increase the concentra...

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Abstract

The invention provides a method for preparing taurine. The method comprises the following steps: carrying out an addition reaction on ethylene oxide and sodium hydrogen sulfite in the presence of a heterogeneous catalyst so as to obtain sodium hydroxyethyl sulfonate at high selectivity; carrying out an ammonolysis reaction on the synthesized sodium hydroxyethyl sulfonate under catalysis of a homogeneous catalyst; and neutralizing, crystallizing, separating and the like, thereby obtaining the finished taurine. Compared with the traditional production process, the process disclosed by the invention has the advantages that by-products in the addition reaction process can be obviously reduced, the temperature and pressure of the ammonolysis reaction are reduced, the reaction time is shortened,and industrial production is easily realized.

Description

technical field [0001] The invention relates to a method for preparing taurine. Background technique [0002] Taurine, also known as taurocholic acid, taurobilin, and chemical name 2-aminoethanesulfonic acid, is an essential non-protein amino acid that exists in almost all organs of humans and mammals in free form. The role of taurine is different from that of other amino acids. It can promote the growth and development of the nervous system, protect the brain, improve memory, and improve optic nerve conduction and visual function. It can also protect the heart, prevent and treat cardiovascular and cerebrovascular diseases and other important diseases. Features. Taurine has high medicinal value and is an important nutrient. It is widely used in functional beverages, pet food, health food, feed, medicine and other fields. It can also be used as biochemical reagents and other organic synthesis intermediates. A fine chemical with wide application value. [0003] [0004] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C303/22C07C309/14
CPCC07C303/32C07C303/22C07C309/08C07C309/14
Inventor 桂振友张静郭斌赵凯飞蔺海政钟子太孔令晓梁静王文李晶李浩陈来中张永振
Owner WANHUA CHEM GRP CO LTD
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