Composite sponge, preparation method thereof, negative pressure drainage dressing, device and medical equipment

A composite sponge and raw material technology, applied in the field of biomedical materials, can solve the problems of inability to achieve water retention effect, water loss and hardening, etc., achieve excellent emulsification, change hardness, and improve water retention performance

Active Publication Date: 2022-06-14
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the actual operation process, it was found that this alginate-polyvinyl alcohol composite sponge material is still easy to lose water and harden during the negative pressure drainage process, and cannot achieve the theoretically expected water retention effect.

Method used

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  • Composite sponge, preparation method thereof, negative pressure drainage dressing, device and medical equipment
  • Composite sponge, preparation method thereof, negative pressure drainage dressing, device and medical equipment
  • Composite sponge, preparation method thereof, negative pressure drainage dressing, device and medical equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A composite sponge, comprising the following components according to its mass fraction:

[0038]

[0039] The esterification degree of the above-mentioned propylene glycol alginate is 25%, the average molecular weight of the polyvinyl alcohol is 110000, and the alcoholysis degree is 85-99%.

[0040] The concrete preparation method of this composite sponge comprises the following steps:

[0041] Step 1: stirring and mixing propylene glycol alginate, polyvinyl alcohol and deionized water evenly, heating up to 90°C, and continuously stirring to dissolve all propylene glycol alginate and polyvinyl alcohol to obtain system A;

[0042] Step 2: add sodium bicarbonate and sodium lauryl sulfate to system A, stir for 30min, stirring speed is 1300rpm to prepare system B;

[0043] Step 3: Cool the system B to 50°C, add glyoxal, stir for 15 min, and stir at a speed of 1500 rpm to prepare system C;

[0044] Step 4: Cool the system C to 40°C, add hydrochloric acid, stir for 8 min...

Embodiment 2

[0047] A composite sponge comprises the following components according to its mass fraction:

[0048]

[0049] The concrete preparation method of this composite sponge comprises the following steps:

[0050] Step 1: Stir and mix propylene glycol alginate and an appropriate amount of deionized water evenly, heat up to 80°C to prepare a first solution, stir and mix polyvinyl alcohol and remaining deionized water evenly, heat up to 90°C to prepare a second solution, and continue Stir to make the first solution and the second solution mix uniformly to prepare system A;

[0051]Step 2: add sodium bicarbonate, calcium bicarbonate and sodium dodecylbenzene sulfonate to system A, stir for 15min, stirring speed is 1400rpm to prepare system B;

[0052] Step 3: Cool the system B to 50°C, add glutaraldehyde, stir for 20 min, and stir at a speed of 1600 rpm to prepare system C;

[0053] Step 4: Cooling system C to 40°C, adding sulfuric acid, stirring for 5 min, and stirring at a rate ...

Embodiment 3

[0056] A composite sponge, comprising the following components according to its mass fraction:

[0057]

[0058] The concrete preparation method of this composite sponge comprises the following steps:

[0059] Step 1: stirring and mixing the polyethylene glycol alginate, polyvinyl alcohol and deionized water evenly, heating the temperature to 90°C, and continuously stirring to dissolve all the polyethylene glycol alginate and the polyvinyl alcohol to obtain System A;

[0060] Step 2: Add ammonium bicarbonate and alkylphenol polyoxyethylene ether to system A, stir for 45 min, and stir at a speed of 1400 rpm to prepare system B;

[0061] Step 3: Cool the system B to 50°C, add formaldehyde, stir for 20 min, and stir at a speed of 1100 rpm to prepare system C;

[0062] Step 4: Cooling system C to 40°C, adding phosphoric acid, stirring for 15 min, and stirring at 1100 rpm to prepare system D;

[0063] Step 5: After stirring the system D evenly, pour it into the mold, conduct c...

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Abstract

The invention discloses a composite sponge with better water retention, a preparation method thereof, a negative pressure drainage dressing, a device and medical equipment. The composite sponge comprises the following components: alginate, polyvinyl alcohol, foaming agent, surfactant, cross-linking agent, acid catalyst, and deionized water. The preparation method of the composite sponge comprises the following steps: stirring alginate, polyvinyl alcohol and deionized water; sequentially adding foaming agent, surfactant, crosslinking agent, acid catalyst, mixing, cooling, stirring and pouring into a mold , carry out the cross-linking reaction, cool and remove the mold and clean it. The alginate used in the present invention will not produce precipitation in the acidic solution, which can promote the water retention performance of the sponge to the greatest extent, reduce the moisture volatilization of the composite sponge during use, change the hardness of the dry composite sponge, and reduce the impact of the dry sponge on The compressive force of the wound can reduce the pain of the patient and speed up the healing process of the patient's wound.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a composite sponge and a preparation method thereof, a negative pressure drainage dressing, a device and medical equipment. Background technique [0002] Negative pressure drainage wound treatment technology is a new technology developed in recent years for the treatment of wounds. It is widely used in the treatment of various acute wounds, skin and soft tissue defects, burn wounds, and chronic refractory wounds. The main principle is to cover or fill the wound with skin and soft tissue defects with a dressing with a built-in drainage tube, then seal it with a biological semi-permeable membrane to make it a closed space, and finally connect the drainage tube to the negative pressure source, intermittently. Negative pressure is generated on the wound surface continuously or continuously to stimulate the growth of granulation tissue and promote wound healing. [0003]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/20A61L15/18A61L15/42A61F13/00
CPCA61L15/18A61L15/20A61L15/24A61L15/28A61L15/42A61L15/425A61F13/00017A61F13/00042A61F13/00068C08L5/04C08L29/04
Inventor 刘琼琼胡克磊李丽花谭荣伟佘振定
Owner SHENZHEN QIKANG MEDICAL DEVICES
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