Vitamin D soft capsule and making method thereof

A production method and technology of vitamins, applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as inability to absorb calcium, difficult to be squeezed out with oil, unstable fusion, etc., to achieve good results Water-locking effect, simple ingredients, and few additives

Active Publication Date: 2019-04-23
威海金思力生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many calcium and vitamin supplement products on the market, and the categories are also relatively complex, but they are generally committed to increasing the content of active ingredients in the products and promoting human body absorption. Few of them improve the freshness of the capsule shell and the uniformity of the contents. Some people are used to cutting the soft capsules and only taking the contents of the soft capsules when taking health care products like soft capsules. This puts forward higher requirements for the production process of the soft capsules. When taking it, the oil can only be squeezed out from the soft capsule, especially the soft capsule made of calcium carbonate, which is more likely to precipitate, and the precipitated calcium carbonate sticks to the capsule shell and is difficult to be squeezed out together with the oil. The body will not be able to absorb calcium

Method used

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  • Vitamin D soft capsule and making method thereof
  • Vitamin D soft capsule and making method thereof
  • Vitamin D soft capsule and making method thereof

Examples

Experimental program
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preparation example Construction

[0029] d. Post-preparation and processing of vitamin D soft capsules; the soft capsules containing the capsule contents prepared in step c are pulled out from the coolant, and dried for the first time in cold wind at room temperature until no obvious coolant water stain remains The soft capsules are washed with petroleum ether twice, then washed in ethanol with a concentration of 95%, and then dried at 30-35°C for 8-12 hours to complete the whole process of making vitamin D soft capsules.

[0030] Among them, among all calcium-containing compounds, calcium carbonate has the highest calcium content, which is suitable for human body to supplement calcium; vitamin D 3 It is the main substance for the human body to supplement vitamin D. It is difficult for people whose skin is not exposed to sunlight to synthesize enough vitamin D by themselves. 3 For their own needs, so vitamin D needs to be taken orally 3 .

[0031] Corn oil is rich in dienaldehyde compounds, palmitic acid, sq...

Embodiment 1

[0036] A vitamin D soft capsule is composed of the following materials in parts by mass:

[0037] Calcium Carbonate 400 parts; Vitamin D 3 0.005 copies;

[0038] 225 parts of soybean oil; 650 parts of gelatin;

[0039] 450 parts of purified water; 325 parts of glycerin;

[0040] 100 parts of glyceryl monostearate; 0.02 parts of titanium dioxide;

[0041] 100 parts of corn oil; 0.2 parts of dibutyl hydroxytoluene.

[0042] In the present embodiment, the manufacturing process of vitamin D soft capsule is:

[0043] a, make the capsule contents; 400 parts of calcium carbonate solids are ground into calcium carbonate powder that can pass through a 200 mesh sieve, and the calcium carbonate powder is uniformly mixed with 225 parts of soybean oil by a colloid mill to obtain a calcium preparation; 0.005 parts Vitamin D 3 Add it to 100 parts of corn oil for mechanical stirring, and continuously add 0.133 parts of dibutyl hydroxytoluene to it while stirring; continue stirring for 1...

Embodiment 2

[0049] A vitamin D soft capsule is composed of the following materials in parts by mass:

[0050] Calcium Carbonate 625 Parts; Vitamin D 3 0.001 copies;

[0051] 550 parts of soybean oil; 425 parts of gelatin;

[0052] 700 parts of purified water; 110 parts of glycerin;

[0053] 400 parts of glyceryl monostearate; 0.01 part of titanium dioxide;

[0054] 200 parts of corn oil; 0.05 parts of dibutyl hydroxytoluene.

[0055] In this example, the difference between the production process of vitamin D soft capsules and Example 1 is that the number of parts added to each component is different, and the number of dibutyl hydroxytoluene added in step a is 0.033 parts, and glyceryl monostearate is 134 parts. part, the dibutyl hydroxytoluene added in step b is 0.017 part, and glyceryl monostearate is 266 parts.

[0056] The content of calcium in each vitamin D soft capsule prepared in this example is 165 mg, and the content of vitamin D is 0.7 micrograms.

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Abstract

The invention discloses a vitamin D soft capsule and a making method thereof. The vitamin D soft capsule is prepared from, by mass, 400-625 parts of calcium carbonate, 0.001-0.005 part of vitamin D3,225-550 parts of soybean oil, 425-650 parts of gelatin, 450-700 parts of purified water, 110-325 parts of glycerin, 100-400 parts of glyceryl monostearate, 0.01-0.02 part of titanium dioxide, 100-200parts of corn oil and 0.05-0.2 part of butylated hydroxytoluene. The making method of the soft capsule comprises the steps of making capsule content; making glue; making the soft capsule containing the capsule content; processing the vitamin D soft capsule after preparation. The vitamin D soft capsule has few additives, and allergic reactions or other discomfort caused by the additives can be avoided; the capsule content is more uniformly and stably mixed, and the phenomena of oil layer separation or calcium carbonate precipitation or the like cannot occur; a capsule shell of the soft capsulehas a water retaining effect.

Description

technical field [0001] The invention relates to a soft capsule and a preparation method thereof, in particular to a vitamin D soft capsule and a preparation method thereof. Background technique [0002] Vitamin D is a fat-soluble vitamin necessary for human beings. It is one of the important regulators of calcium and phosphorus metabolism. It can promote the body's absorption of calcium and phosphorus, maintain normal blood calcium and phosphorus levels, and participate in the differentiation of many tissue cells. and proliferation of life processes. The most important vitamin D currently known is vitamin D 2 (ergocalciferol) and Vitamin D 3 (cholecalciferaldehyde). Vitamin D 2 It is produced by ergosterol in plants irradiated by ultraviolet rays, but there are very few stocks in nature. Vitamin D 3 It is transformed from 7-dehydrocholesterol contained in human epidermis and dermis by ultraviolet radiation in sunlight. Vitamin D 2 and vitamin D 3 The effect and mech...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K33/10A61K31/593A61K47/44A61K47/42A61K47/14A61K47/10A61P3/02
CPCA61K47/14A61P3/02A61K9/4825A61K9/4858A61K31/593A61K33/10A61K2300/00
Inventor 林云
Owner 威海金思力生物科技股份有限公司
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