Inorganic-organic sun-screening agent composite microsphere and preparation method thereof

An organic sunscreen and composite microsphere technology, applied in the field of daily chemical industry, can solve the problems of increasing skin allergies, aging and lesion risks, human safety risks, skin adverse reactions, etc., to reduce photodegradation and skin irritation , prevent penetration into the skin or hair follicles, superior human body safety effect

Active Publication Date: 2019-05-21
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing various inorganic and organic sunscreen raw materials generally have problems such as human safety risks and poor use feeling
On the one hand, organic sunscreens are mostly aromatic compounds, which are easily degraded and produce ROS induced by ultraviolet rays, increasing the risk of skin allergies, aging and lesions, and organic sunscreens can penetrate the stratum corneum or penetrate into the dermis through hair follicles, and be absorbed by the whole body , causing potential safety hazards, and organic sunscreens tend to feel greasy on the skin
On the other hand, inorganic sunscreen nanoparticles also have the risk of hair follicle accumulation and percutaneous absorption, and produce ROS to cause adverse skin reactions; in order to obtain ideal protective effects, high concentrations of inorganic nanoparticles (10-30%) are often added to the formula. It is easy to reunite, resulting in obvious whitening, and the skin feels thick, and the usability is poor

Method used

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  • Inorganic-organic sun-screening agent composite microsphere and preparation method thereof
  • Inorganic-organic sun-screening agent composite microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The pH value of 0.9g nano-titanium dioxide (particle diameter is 10-25nm, anatase type) is adjusted to 3, ultrasonic 5min obtains water dispersant, this water dispersant is standby as aqueous phase;

[0036] Weigh 4.3g of hydrogen-containing silicone oil (PMHS, hydrogen content 3%), 7.5g of avobenzone and 10.7g of vinyl-terminated silicone oil (Vi-PDMS) and mix them uniformly as the oil phase;

[0037] Mix the above water phase and oil phase, and add 2×10 －5 (Based on the mass fraction of Pt in the mixture of PMHS and Vi-PDMS) chloroplatinic acid catalyst, homogenized at 20000r / min for 2min to obtain a white emulsion, reacted in the dark at 25°C for 24h, and prepared the product at 60°C Dry and grind to obtain inorganic-organic sunscreen composite microspheres.

[0038] Such as figure 1 As shown in (a) and (b), it can be seen from the SEM image of the microsphere and the photomicrograph of the emulsion that the particle size of the microsphere is 3-20 μm; the ultravio...

Embodiment 2

[0040] Utilize ultrasound to disperse 0.15g zinc oxide (particle size is 30nm) to 30g10 -4 mol / L cetyltrimethylammonium bromide (CTAB) aqueous solution, add 0.15g nano silicon dioxide (about 16nm), and adjust the pH value to 4, ultrasonic 5min, get water dispersant and disperse the water The agent is used as the aqueous phase for subsequent use;

[0041] Weigh 9g methyl methacrylate (MMA), and add 0.45g terexylylene biscamphorsulfonic acid (Mai Su Ning filter ring) and mix uniformly as the oil phase;

[0042] Mix the water phase and the oil phase, then add 0.3g of potassium persulfate (KPS) as a catalyst, homogenize at 20,000r / min for 2min to obtain a white emulsion, fill it with nitrogen and stir for 12h at 20°C in the dark, and the product is simply After filtering, vacuum-dry in the dark at 40°C for 36 hours to obtain PMMA microspheres with a mysuning filter ring inside and titanium dioxide on the surface.

[0043]The particle size of the microspheres is 0.1-10 μm; the ul...

Embodiment 3

[0045] Utilize ultrasound to disperse 0.6g of nano-titanium dioxide (particle size is 100nm) into 30g of 10-4mol / L CTAB solution, and ultrasonic 10min to obtain a water dispersant, the water dispersant is used as the water phase for standby;

[0046] Weigh 20g styrene, 3g octocrylene (OCR), 3g ethylhexyl methoxycinnamate (EHMC) and mix well as the oil phase;

[0047] Mix the water phase and the oil phase, and add 0.2g of azobisisobutyronitrile as a catalyst, homogenize at 20,000r / min for 5min to obtain a white emulsion, react in the dark at 60°C for 1h, and dissolve the product at 40°C Vacuum drying for 36 hours and grinding to obtain PS microspheres with ORC and EHMC inside and ZnO on the surface.

[0048] The particle size of the microspheres is 100-200 μm; the ultraviolet light test shows that the inorganic-organic sunscreen composite microspheres have a full-band sunscreen effect, which is twice as high as that of zinc oxide alone and ORC and EHMC composite sunscreen; Oxy...

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Abstract

The invention discloses an inorganic-organic sun-screening agent composite microsphere. The microsphere comprises a polymer microsphere body, an inorganic sun-screening agent nano particle and an organic sun-screening agent, and the inorganic sun-screening agent nano particle is loaded on the surface of the polymer microsphere body; the organic sun-screening agent is wrapped by the polymer microsphere body. The composite microsphere has a full-wave band sun-screening function and is low in irritation and good in safety.

Description

technical field [0001] The invention relates to the field of daily chemical industry, in particular to an inorganic-organic sunscreen composite microsphere and a preparation method thereof. Background technique [0002] With the continuous improvement of people's pursuit of skin beauty and health, sunscreen products have become the fastest growing branch of daily chemicals. my country is an emerging market for sunscreen products, and the development potential of sunscreen cosmetics is still huge. The ultraviolet bands with skin damage in sunlight include short-wave UVB (290-320nm) and long-wave UVA (320-400 nm) bands, where UVB can cause immediate skin damage (such as erythema, sunburn), while UVA can penetrate deep into the dermis and produce Reactive oxygen species (ROS) is an important factor leading to skin photoaging and even lesions. The core functional ingredient of sunscreen products is sunscreen. Existing commercial sunscreens include organic sunscreens (such as o...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/27A61K8/29A61K8/35A61K8/37A61K8/46A61Q17/04
Inventor 王靖喻明英杨成曹光群
Owner JIANGNAN UNIV
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