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A polyethyleneimine-based iodine-loaded antibacterial cellulose material, preparation method and application

A polyethyleneimine-based, polyethyleneimine technology, applied in antibacterial drugs, pharmaceutical formulations, active ingredients of iodine compounds, etc. Ideal and other issues, to achieve the effect of excellent antibacterial effect, long-lasting antibacterial performance, and low equipment requirements

Active Publication Date: 2021-07-09
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These iodophors basically exist in the form of liquid, paste or amorphous powder, the stability is not ideal, and the bactericidal level and toxic and side effects are also uneven.
In addition, the surfactants used in these products such as polyethylene glycol, nonylphenol polyoxyethylene ether, polyalcohol ether, polyvinyl alcohol, alkyl sulfonate, quaternary ammonium salt, etc. act as carriers and auxiliary agents in povidone iodine. The role of soluble, often lead to a considerable part of the "iodine existence form" does not have bactericidal activity and wasted in vain, but also leave yellow stains on the skin and even burn the skin

Method used

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  • A polyethyleneimine-based iodine-loaded antibacterial cellulose material, preparation method and application
  • A polyethyleneimine-based iodine-loaded antibacterial cellulose material, preparation method and application
  • A polyethyleneimine-based iodine-loaded antibacterial cellulose material, preparation method and application

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preparation example Construction

[0025] A preparation method of polyethyleneimine-based iodine-loaded antibacterial cellulose material, comprising the following steps:

[0026] Step 1: oxidizing the cellulose material in an aqueous solution containing an oxidizing agent, and washing to obtain the oxidized cellulose material after the oxidation is completed;

[0027] Cellulosic materials are natural cellulosic materials, regenerated cellulosic materials or mixtures thereof; cellulosic materials are in the form of monofilaments, multifilaments, braids, films, papers, blocks and hydrogels; the crystalline structure of cellulose used It is cellulose I, II, III and IV crystal forms or mixtures thereof.

[0028] The oxidizing agent is one of sodium periodate, potassium periodate and hydrogen peroxide; the amount of aldehyde groups on the oxidized cellulose material obtained after oxidation treatment is 50-500 μmol / g, preferably 100-300 μmol / g.

[0029] Step 2: immerse the oxidized cellulose material obtained in st...

Embodiment 1

[0034] Prepare polyethyleneimine-based iodine-loaded antibacterial cellulose material according to the following steps:

[0035] Step 1: Put 2g of regenerated cellulose gel film into a sodium periodate solution with a concentration of 1g / L and pH=5, oxidize it at 25°C for 6h, and then wash it with water to obtain a dialdehyde cellulose gel film ;

[0036] Step 2: Immerse the dialdehyde cellulose gel film obtained in step 1 in a PEI solution with a concentration of 0.05% and pH=10, carry out grafting reaction at room temperature, wash with water after 2 hours, and obtain polyethyleneimine after drying Grafted cellulose film;

[0037] Step 3: Place the polyethyleneimine grafted cellulose film obtained in step 2 in an iodine-potassium iodide solution with a pH of 6 and a concentration of 0.5%, treat it at room temperature for 1 hour, and dry it to obtain polyethyleneimine-based iodine-loaded antibacterial Cellulose film.

[0038] The iodine content in the polyethyleneimine-bas...

Embodiment 2

[0043] Prepare polyethyleneimine-based iodine-loaded antibacterial cellulose material according to the following steps:

[0044] Step 1: Put 2g of regenerated cellulose gel film into a sodium periodate solution with a concentration of 4g / L and pH=5, oxidize it at 25°C for 4 hours, and then wash it with water to obtain a dialdehyde cellulose gel film ;

[0045]Step 2: Immerse the dialdehyde cellulose gel film obtained in step 1 in a PEI solution with a concentration of 0.05% and pH=9, carry out grafting reaction at room temperature, wash with water after 2 hours, and obtain polyethyleneimine after drying Grafted cellulose film;

[0046] Step 3: The polyethyleneimine grafted cellulose membrane obtained in step 2 is placed in an iodine-potassium iodide solution with a concentration of 0.5% at pH=6, treated at 25°C for 1 hour, and dried to obtain polyethyleneimine-based iodine-loaded antibacterial Cellulose film.

[0047] The iodine content in the polyethyleneimine-based iodine...

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Abstract

The invention discloses a polyethyleneimine-based iodine-loaded antibacterial cellulose material, its preparation method and its application. The preparation method comprises the following steps: Step 1: oxidizing the cellulose material in an aqueous solution containing an oxidizing agent, and cleaning it after the oxidation is completed Obtain oxidized cellulose material; step 2: immerse the oxidized cellulose material obtained in step 1 in an aqueous solution of polyethyleneimine with a mass concentration of 0.01% to 5%, after complete reaction, wash and dry to obtain polyethyleneimine grafted cellulose Material; step 3: immerse the polyethyleneimine grafted cellulose material obtained in step 2 in an iodine-iodide aqueous solution with a mass concentration of 0.1 to 5%, and dry it after complete reaction to obtain the desired polyethyleneimine-based carrier Iodine antibacterial fiber material; the mass ratio of iodine and iodide in iodine-iodide is 1:1 to 1:2; the preparation method of the present invention is simple, the reaction conditions are mild, and the obtained iodine-carrying material is solid, with uniform iodine distribution and excellent antibacterial performance Long-lasting, excellent antibacterial effect, easy to carry, no yellowing.

Description

technical field [0001] The invention relates to the field of preparation of antibacterial materials, in particular to a polyethyleneimine-based iodine-loaded antibacterial cellulose material, a preparation method and an application. Background technique [0002] In recent years, a variety of bacterial diseases caused by microorganisms have brought great harm and panic to human beings; at the same time, the abuse of a large number of broad-spectrum antibiotics has led to the emergence of a large number of drug-resistant strains and mutant strains, so it has high-efficiency and broad-spectrum antibiotics Antibacterial agents need to be developed and applied urgently. Among many antibacterial agents, iodine is recognized as the safest and most reliable fungicide in the world. It has low tissue toxicity, strong killing ability to bacteria, fungi, viruses, spores, etc., and does not produce drug resistance; Sublimation, poor stability, almost insoluble in water, so its applicati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/18A61K9/70A61K47/38A61K47/34A61P31/04
Inventor 张胜利凯橙橙刘伯芳张思略周祚万韦炜胡代燕
Owner SOUTHWEST JIAOTONG UNIV
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