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Effervescence slow release agent containing probiotics and preparation method and application of effervescence slow release agent

A technology of probiotics and sustained-release agents, applied in the field of pharmaceutical applications, can solve the problems of short drug effect time, destruction of beneficial bacteria, damage to the autoimmune system of the female reproductive tract, etc. Effect

Inactive Publication Date: 2019-06-07
赛奈金生物科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide an effervescent sustained-release agent containing probiotics and its preparation method and application. When using this method of administration, it will cause damage to the beneficial bacteria in the female reproductive tract, and the drug will be effective for a short time in the female reproductive tract, which will seriously damage the autoimmune system of the female reproductive tract.

Method used

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  • Effervescence slow release agent containing probiotics and preparation method and application of effervescence slow release agent

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Experimental program
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Effect test

Embodiment 1

[0027] An effervescent sustained-release agent containing probiotics, which according to mass fraction includes the following components: microcrystalline cellulose 5%, sodium bicarbonate 10%, tartaric acid 15%, lactic acid powder 3%, chitosan 7% , EGCG 6%, Brij35 5%, micro powder silica gel 2%, povidone K30 and absolute ethanol mixed solution 0.5%, probiotic mixture 15%, magnesium stearate 0.2%.

[0028] According to the above formula, the preparation method adopted is as follows:

[0029] (1) Take Brij35, micro-powder silica gel and a mixed solution of povidone K30 and absolute ethanol to mix, heat it at 60°C and then cool it to obtain mixture A;

[0030] (2) Take sodium bicarbonate, tartaric acid, lactic acid, and EGCG respectively through 80 mesh sieve, add chitosan oligosaccharide and mix uniformly to obtain mixture B, then add mixture B to mixture A to make soft material, pass through 20 mesh sieve to prepare wet granules C; Then the wet granules C are dried in a 40 ℃ drying o...

Embodiment 2

[0034] An effervescent sustained-release agent containing probiotics, which includes the following components according to mass fraction: microcrystalline cellulose 8%, sodium bicarbonate 15%, tartaric acid 18%, lactic acid powder 5%, chitosan 10% , EGCG 7%, Brij35 6%, micro powder silica gel 4%, povidone K30 and anhydrous ethanol mixed solution 1.5%, probiotic mixture 20%, magnesium stearate 1.2%.

[0035] According to the above formula, the preparation method adopted is as follows:

[0036] (1) Take Brij35, micro-powder silica gel and a mixed solution of povidone K30 and absolute ethanol and mix them, heat them at 65°C and then cool them to obtain mixture A;

[0037] (2) Take sodium bicarbonate, tartaric acid, lactic acid, and EGCG respectively through 80 mesh sieve, add chitosan oligosaccharide and mix uniformly to obtain mixture B, then add mixture B to mixture A to make soft material, pass through 20 mesh sieve to prepare wet granules C; Then the wet granules C are dried in a 4...

Embodiment 3

[0041] An effervescent sustained-release agent containing probiotics, which includes the following components according to mass fraction: microcrystalline cellulose 13%, sodium bicarbonate 20%-30%, tartaric acid 20%, lactic acid powder 9%, chitosan Sugar 12%, EGCG 8%, Brij35 9%, micronized silica gel 6%, povidone K30 and absolute ethanol mixed solution 3%, probiotic mixture 30%, magnesium stearate 3.1%.

[0042] According to the above formula, the preparation method adopted is as follows:

[0043] (1) Take Brij35, micro-powdered silica gel and a mixed solution of povidone K30 and absolute ethanol to mix, heat it at 70°C and then cool it to obtain mixture A;

[0044] (2) Take sodium bicarbonate, tartaric acid, lactic acid, and EGCG respectively through 80 mesh sieve, add chitosan oligosaccharide and mix uniformly to obtain mixture B, then add mixture B to mixture A to make soft material, pass through 20 mesh sieve to prepare wet granules C; Then the wet granules C are dried in a 45°C...

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Abstract

The invention discloses an effervescence slow release agent containing probiotics and a preparation method and application of the effervescence slow release agent, and belongs to the technical field of medicine application. The effervescence slow release agent comprises the following components in percentage by mass of 5%-20% of microlite cellulose, 10%-30% of sodium bicarbonate, 15%-25% of tartaric acid, 3%-16% of lactic acid powder, 7%-18% of chitosan oligosaccharide, 6%-10% of EGCG, 5%-12% of Brij35, 2%-10% of colloidal silicon dioxide, 0.5%-5% of a polyvidone K30 and anhydrous ethanol mixed solution, 15%-45% of a probiotic mixture, and 0.2%-6% of magnesium stearate. The main components are the probiotic mixture, and through breeding with a modern technology, the probiotic mixture has good compatibility with inherent probiotics of human bodies. In addition, the purely natural components for a formula, namely tea polyphenols, contain the EGCG, the chitosan oligosaccharide, the lacticacid and the like, have high killing effect on harmful bacteria, and besides, can also be used as nutrient substances of probiotics. The effervescence slow release agent has great help to colonization of probiotics to female genital tracts, substances killing harmful bacteria, such as the lactic acid and the hydrogen peroxide, can be massively produced, and an autoimmunity system can be restored,so that the problem of repeated breaking out of inflammation to the female genital tracts can be solved fundamentally.

Description

Technical field [0001] The invention relates to an effervescent sustained-release agent containing probiotics and a preparation method and application thereof, and belongs to the technical field of medical applications. Background technique [0002] At present, there are two main pharmaceutical dosage forms for the treatment of female reproductive tract diseases on the market. They are solid preparations and liquid preparations. However, when solid preparations are used, the internal physiological structure of the female reproductive tract is wrinkled. The deep part of the fold cannot be reached during use, so the treatment effect on the diseased part located in the deep part of the fold structure is not good, so it needs a long time to continue to use the medicine. In addition, when the solid preparation is used, the liquid preparation will have the following three situations when using: [0003] 1. Although liquid preparations can achieve a comprehensive and better therapeutic ef...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K47/38A61K35/741A61P15/02A61K31/19A61K31/353A61K31/702
Inventor 马浤轩
Owner 赛奈金生物科技(上海)有限公司