Coating structure of medical biodegradable zinc alloy stent and preparation method thereof

A zinc alloy and drug coating technology, applied in metal material coating technology, coating, medical science and other directions, can solve the problems of uncontrollable degradation rate, uncontrollable degradation rate and low mechanical strength of pure zinc and zinc alloy materials , to achieve the effect of improving pitting corrosion defects, good biocompatibility, and no toxic side effects

Active Publication Date: 2019-06-28
赵亚芳 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing pure zinc and zinc alloys still have defects such as low mechanical strength, difficult processing, uncontrollable degradation rate, and fast pitting corrosion.
[0005] The coating structure and preparation method of a medical biodegradable zinc alloy stent of the present invention is to propose a solution to the defects of uncontrollable degradation rate and fast pitting corrosion of pure zinc and zinc alloy materials

Method used

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  • Coating structure of medical biodegradable zinc alloy stent and preparation method thereof
  • Coating structure of medical biodegradable zinc alloy stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1, oxide-coated stent A1:

[0031] Take the polished zinc alloy bracket and put it into a vacuum tube furnace, evacuate it to -0.1Mpa, then fill it with high-purity oxygen to 0.12Mpa; then heat the vacuum tube furnace to 200°C and keep it for 2 hours; finally cool it naturally and release it slowly Oxygen to normal pressure to obtain S1 oxide-coated stent A1.

Embodiment 2

[0032] Embodiment 2, composite coated stent A2:

[0033] Take the polished zinc alloy bracket and put it into a vacuum tube furnace, evacuate it to -0.1Mpa, then fill it with high-purity oxygen to 0.12Mpa; then heat the vacuum tube furnace to 200°C and keep it for 2 hours; finally cool it naturally and release it slowly Oxygen to normal pressure, the S1 oxide-coated stent was obtained.

[0034] Take polylactic acid (PLA) with a molecular weight of 80,000 and polytrimethylene carbonate (PTMC) with a molecular weight of 30,000 and mix and dissolve in methylene chloride. The mass ratio of PLA: PTMC is 2: 3. The mass concentration is 0.5%; then use ultrasonic atomization spraying to coat the mixed solution on the stent containing the S1 oxide coating; finally put the coated stent in a vacuum drying oven, set the temperature at 45°C for 36h, and pump Vacuum to -0.1Mpa. After drying, the composite coated stent A2 containing S1 and S2 is obtained.

Embodiment 3

[0035] Embodiment 3, composite coated stent A3:

[0036] S1, S2 composite coating stent preparation method, same as embodiment 2

[0037] First get 0.1g rapamycin and 0.35g molecular weight polylactic acid-glycolic acid copolymer (PLGA) of 10,000 and dissolve in acetone, the mass concentration of mixed solution is 1.1%; The solution was coated on the composite coating stent containing S1 and S2; finally, the coated stent was placed in a vacuum drying oven, the temperature was set at 40°C, the time was 24h, and the vacuum was pumped to -0.1Mpa. After drying, the composite coating stent A3 containing S1, S2, and S3 is obtained.

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Abstract

Provided are a coating structure of a medical biodegradable zinc alloy stent and a preparation method thereof. The stent consists of a coating covering the surface of a zinc alloy stent body (Zn), andcomprises three layers of S1, S2 and S3, the S1 is an oxide coating, the S2 is a polymer coating, and the S3 is a drug coating.

Description

technical field [0001] The invention belongs to the field of medical implant materials, and in particular relates to a coating structure and a preparation method of a biodegradable zinc alloy stent. Background technique [0002] Among the biomedical implant materials, medical metal implant materials are widely used in clinical practice, such as 316L, 304V, titanium alloy, cobalt-chromium alloy, etc. These materials are not degradable in the human body and remain permanently. When implanted into the human body to reach the service period, a second operation is required to remove it, which brings physical pain and economic burden to the patient. In recent years, there have been more and more reports in the clinical practice of stent implantation. The rate of middle and late thrombosis and restenosis of non-degradable metal stents is on the rise, causing great pain to patients after treatment, and also losing the initial operation. purpose of treatment. [0003] Over the year...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/14A61L31/16C23C8/12
Inventor 赵亚芳其他发明人请求不公开姓名
Owner 赵亚芳
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