Preparation method of calcium zinc gluconate oral solution
A technology of calcium zinc gluconate and calcium gluconate, which is applied in the field of medicine, can solve problems such as low production efficiency, easy crystallization, and high viscosity of the solution, so as to reduce the impact of human blood sugar concentration, reduce safety risks, and fast filtration speed Effect
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Embodiment 1
[0018] Embodiment 1. in a kind of calcium zinc gluconate oral solution, comprise the component of following parts by weight:
[0019] Calcium gluconate 600 parts;
[0020] Zinc gluconate 30 parts;
[0021] 100 parts of lysine hydrochloride;
[0022] 120 parts of lactic acid;
[0023] Stevia 10 parts;
[0024] 10 parts of cool alcohol;
[0025] 5 parts of ethylparaben;
[0026] 10 parts of essence;
[0027] Appropriate amount of sodium hydroxide (the amount required to adjust the pH to 4.0-5.0);
[0028] Purified water 10000 parts.
[0029] The preparation method of above-mentioned calcium zinc gluconate oral solution comprises the following steps:
[0030] (1) Boil 8L of purified water for 20 minutes, add calcium gluconate, and keep boiling for 10 minutes to obtain reagent 1;
[0031] (2) Reagent 2 obtained by adding zinc gluconate, lysine hydrochloride, stevioside and cool alcohol to reagent 1 obtained in step (1), and keeping boiling for 40 minutes;
[0032] (3) Ad...
Embodiment 2-4
[0036] The formulation components and preparation method of Examples 2-4 are the same as those of Example 1, except that the amounts of stevioside, ethylparaben and essence are different, see Table 1 for the specific amounts.
[0037] The calcium zinc gluconate oral solution obtained by using the formula in Examples 1-4 was tested for mouthfeel and fragrance, and the results are shown in Table 1 below.
[0038] Table 1: Experimental results of different amounts of stevioside, ethylparaben and essence (parts by weight)
[0039]
[0040] In the above table, flavors include but not limited to apple flavor and sweet orange juice flavor. From the experimental results in the above table, it can be seen that the weight ratio of stevioside, essence and relieving alcohol is 12:12:14 and the experimental effect is the best.
Embodiment 5-8
[0042] The formula components and preparation methods of Examples 5-8 are the same as those in Example 1, except that the amount of ethylparaben is different, see Table 2 for the specific amount.
[0043] The calcium zinc gluconate oral solution obtained by utilizing the formula in Examples 5-8 was subjected to a bacteriostatic efficacy test, and the results are shown in Table 2 below.
[0044] Table 2: The bacteriostatic effect test bacterial count of the ethylparaben of different consumptions drops lg value (weight part)
[0045]
[0046] In the bacteriostatic efficacy test, take 10ml of the test product for bacteriostatic test, add pH 7.0 sterile sodium chloride-peptone buffer to 100ml, and make a 1:10 test solution. Prepare 5 parts of test product, blank oral liquid solution and diluent. Each solution to be tested is inoculated with a test bacterium, and an appropriate amount of the test product is taken, and transferred to 5 suitable sterile containers, each container...
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