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A kind of preparation method of nano zinc oxide doped hydroxyapatite porous bioceramics

A technology of nano-hydroxyapatite and nano-zinc oxide, which is applied in the fields of ceramic products, drug delivery, tissue regeneration, etc., can solve the problems of mismatch between degradation and osteogenesis rate, long-term pain at the bone graft site, and decreased biological activity of materials. Achieve good osteogenic induction ability, improve osteogenic induction ability, and improve bone formation ability

Active Publication Date: 2022-02-15
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The artificial bone materials currently used clinically have delayed union or nonunion of bone graft, mismatch between the degradation of artificial bone and the rate of osteogenesis, fragmentation and deformation of bone graft material, collapse of bone after bone graft leading to loss of bone height, post-graft infection, Long-term sinus formation, long-term pain at the bone graft site, etc.
[0003] The porous hydroxyapatite-based artificial bone materials prepared by the prior art have the following problems: (1) In order to improve the mechanical properties of the material and obtain a stable porous structure, the material needs to be sintered at high temperature for a long time
Excessive sintering temperature and long holding time will cause partial decomposition of hydroxyapatite, resulting in a decrease in the biological activity of the material; (2) In the process of preparing the material, binders (such as polyvinyl alcohol, sodium silicate, etc.) need to be added ), there is a small amount of residue after high temperature sintering
The residual binder will not degrade, which reduces the bioactivity and osteogenic activity of the material, and even produces toxicity; (3) The degradation of the material does not match the osteogenesis rate during the application process, and the role of materials and elements that promote osteogenesis is limited. It is easy to cause delayed union or non-union of bone graft after implantation

Method used

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  • A kind of preparation method of nano zinc oxide doped hydroxyapatite porous bioceramics
  • A kind of preparation method of nano zinc oxide doped hydroxyapatite porous bioceramics
  • A kind of preparation method of nano zinc oxide doped hydroxyapatite porous bioceramics

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Experimental program
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Effect test

Embodiment 1

[0027] (1) Using nano-zinc oxide with a purity of ≥99.9% and a particle size of 60nm and nano-hydroxyapatite powder with a purity of ≥99.7% and a particle size of 100nm as raw materials, weigh the nano-zinc oxide according to the mass ratio of 1%:99%. Zinc and nano-hydroxyapatite powder.

[0028] (2) Put the powder raw material weighed in step (1) into an agate ball mill jar, add agate balls, absolute ethanol and dispersant polyethylene glycol (the amount of polyethylene glycol added is 0.7% of the mass of the raw material powder , the mass ratio of agate grinding balls is 3:1, the mass ratio of large, medium and small balls is 1:3:6), placed on a planetary ball mill, after 6 hours of ball milling, dried and ground in a vacuum oven at 60°C to obtain nano-oxidized Zinc doped hydroxyapatite composite powder.

[0029] (3) The nano-zinc oxide-doped hydroxyapatite composite powder obtained in step (2) was uniformly mixed with the powder of ammonium bicarbonate, a pore-forming agen...

Embodiment 2

[0033] Using nano-zinc oxide with a purity of ≥99.9% and a particle size of 60nm and nano-hydroxyapatite powder with a purity of ≥99.7% and a particle size of 100nm as raw materials, weigh nano-zinc oxide and nano-hydroxyapatite according to a mass ratio of 3%:97%. Apatite powder, other process steps and parameters are consistent with embodiment 1.

Embodiment 3

[0035] Using nano-zinc oxide with purity ≥ 99.9% and a particle size of 60nm and nano-hydroxyapatite powder with a purity ≥ 99.7% and a particle size of 100nm as raw materials, weigh nano-zinc oxide and nano-hydroxyapatite according to a mass ratio of 5%:95%. Apatite powder, other process steps and parameters are consistent with embodiment 1.

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Abstract

The invention relates to a preparation method of nano-zinc oxide-doped hydroxyapatite porous bioceramic, belonging to the technical field of preparation of biomedical materials. The method of the present invention uses nano-zinc powder and hydroxyapatite powder as raw materials, weighs according to the mass ratio ZnO:HA=1~7%:99%~93%, and then obtains composite powder after ball milling, and the composite powder Mix it with the pore-forming agent ammonium bicarbonate, mix it evenly, and press it to obtain a green body, and use the spark plasma sintering method to prepare nano-zinc oxide-doped hydroxyapatite porous bioceramic; the porous bioceramic prepared by the present invention is not only pure in composition , the porosity of the material can reach 40-70% and is controllable, and the addition of nano-zinc oxide can improve the osteogenic induction ability of porous bioceramics, thereby improving the bone formation ability around the implant site; by controlling the porosity of the material , can prepare bioceramics with different requirements, which are suitable for bone scaffolding, filling and repairing materials.

Description

technical field [0001] This article relates to a preparation method of nanometer zinc oxide doped hydroxyapatite porous bioceramic, which belongs to the technical field of preparation of biomedical materials. Background technique [0002] In recent years, with the rapid development of my country's national economy, the improvement of people's living standards, the aging of the population, and the significant improvement of medical and health standards, more and more orthopedic patients are caused by work-related injuries, traffic accidents, bone tumors, bone tuberculosis and other diseases. The artificial bone materials currently used clinically have delayed union or nonunion of bone graft, mismatch between the degradation of artificial bone and the rate of osteogenesis, fragmentation and deformation of bone graft material, collapse of bone after bone graft leading to loss of bone height, post-graft infection, Long-term sinus tract formation, long-term pain at the bone graft...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/447C04B35/622C04B35/64C04B38/02A61L27/02A61L27/10A61L27/12A61L27/50A61L27/56
CPCC04B35/447C04B35/622C04B35/64C04B38/02A61L27/56A61L27/12A61L27/50A61L27/025A61L27/10A61L2430/02A61L2400/12C04B2235/3284C04B2235/5454C04B2235/6562C04B2235/6567C04B2235/658C04B2235/666C04B38/0054C04B38/0051C04B38/0074
Inventor 张玉勤朱斌孟增东罗丽琳何远怀
Owner KUNMING UNIV OF SCI & TECH