Polyelectrolyte composition hydrogel hemostatic based on polysaccharide/polypeptide

A polyelectrolyte and composite technology, which is applied in drug delivery, medical science, pharmaceutical formulation, etc., can solve the problems of inability to make gel microspheres and limited application fields, and achieve good biocompatibility and biocompatibility Good, the effect of improving the mechanical strength

Active Publication Date: 2019-08-23
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the calcium alginate microgel is formed, it can continue to assemble with positively charged macromolecules such as chitosan in the cross-linked phase to form microcapsules, so its core is the calcium alginate hydrogel formed by ionic bond cross-linking ; Thereby the oil phase in this invention is indispensable, if do not have oil phase, then can't carry out complex coacervation method and prepare gel microsphere
This invention involves the preparation of micron-scale drug-loaded gel microspheres, rather than the preparation of macro-scale wound dressing hydrogels, that is, the core content of this invention is the preparation of granules rather than macro-gels, and the application field is limited

Method used

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  • Polyelectrolyte composition hydrogel hemostatic based on polysaccharide/polypeptide
  • Polyelectrolyte composition hydrogel hemostatic based on polysaccharide/polypeptide
  • Polyelectrolyte composition hydrogel hemostatic based on polysaccharide/polypeptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Use a mechanical stirrer to prepare a mixed polysaccharide solution, add 10g xanthan gum and 10g sodium alginate to 500mL aqueous solution to obtain a viscous mixed polysaccharide solution with a xanthan gum content of 2% and a sodium alginate content of 2%. This solution is marked as 1 number solution. Prepare the peptide solution using magnetic stirring, add 5g polylysine hydrochloride and 0.5g calcium chloride to 100mL water to obtain a mixed solution with 5% polylysine content and 0.5% calcium chloride content, which is marked as solution a. Add 5g polylysine hydrochloride and 1g calcium chloride to 100mL water to obtain a mixed solution with 5% polylysine content and 1% calcium chloride content, which is marked as solution b. Add 10g polylysine hydrochloride and 1g calcium chloride to 100mL water to obtain a mixed solution with a polylysine content of 10% and a calcium chloride content of 1%, which is marked as solution c. Take 1mL of No. 1 solution, take 3 times ...

Embodiment 2

[0045] Use mechanical stirrer to prepare mixed polysaccharide solution, add 10g xanthan gum, 10g sodium alginate and 10g hyaluronic acid to 500mL aqueous solution, obtain xanthan gum content 2%, sodium alginate content 2%, hyaluronic acid content 2% Viscous mixed polysaccharide solution, the solution is marked as No. 2 solution. Take 1mL of No. 2 solution, take 3 times in total, put it in three petri dishes, and mix it with 1mL of solution a / b / c in Example 1 respectively, and the mixed solution forms a hydrogel within 50s / 30s / 20s glue.

[0046] figure 1 middle, figure 1 (a) is the storage modulus and the loss modulus value of the polyelectrolyte composite hydrogel prepared in embodiment 1, figure 1 (b) is the storage modulus and the loss modulus value of the polyelectrolyte composite hydrogel prepared in Example 2 Wherein G is the storage modulus, unit Pa; G' is the loss modulus, unit Pa, test condition The temperature is 25°C, the oscillation pressure is 1Pa, and the osci...

Embodiment 3

[0049] Use mechanical stirrer to prepare mixed polysaccharide solution, add 5g xanthan gum, 15g sodium alginate and 5g chondroitin sulfate in 500mL aqueous solution, obtain xanthan gum content 1%, sodium alginate content 3%, chondroitin sulfate content 1% Viscous mixed polysaccharide solution, the solution is marked as No. 3 solution. Take 1mL of No. 3 solution, take it 3 times in total, place it in three petri dishes, and mix it with 1mL of the solution a / b / c in Example 1 respectively, and the mixed solution forms hydrocoagulation within 50s / 40s / 30s respectively. glue.

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Abstract

The invention provides a polyelectrolyte composition hydrogel hemostatic based on polysaccharide / polypeptide. The polyelectrolyte composition hydrogel hemostatic is prepared from a polysaccharide solution and a polypeptide solution through mixing and physical crosslinking, wherein the polysaccharide solution comprises a xanthan gum; and the polypeptide solution comprises polylysine. After the polysaccharide solution and the polylysine solution of different ratios are mutually mixed, physical crosslinking is implemented under electrostatic interactions of molecules and interactions of hydrogenbonds of the molecules, and then hydrogel is rapidly generated. Because of advantages of being rapid in gelatinization, good in biocompatibility, and the like, the hydrogel can be used as the hydrogelhemostatic and is applied to trauma hemostasis and surgical hemostasis.

Description

technical field [0001] The invention relates to the technical field of polyelectrolyte complexes, in particular to a polysaccharide / polypeptide-based polyelectrolyte complex hydrogel hemostatic agent. Background technique [0002] Polyelectrolyte complexes, also known as polyion complexes, refer to substances formed by intermolecular electrostatic interactions between two polyelectrolytes with opposite charges in aqueous solution. When the electrostatic interaction force between molecules in the polyelectrolyte complex system is moderate (the pH value of the system is close to the pKa value of the polymer), the polyelectrolyte complex can form a hydrogel, which is also called a polyelectrolyte complex object hydrogel. During the preparation of the polyelectrolyte complex hydrogel, if there are other intermolecular forces such as intermolecular hydrogen bonds, hydrophilic-hydrophobic interactions, and host-guest interaction forces in the system, the strength of the polyelect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/00C08L5/04C08L5/08C08L77/04A61L26/00
CPCA61L26/0052A61L26/008A61L2400/04C08J3/075C08J3/24C08J2305/00C08J2305/04C08J2305/08C08J2405/00C08J2405/04C08J2405/08C08J2477/04C08L5/00C08L77/04C08L5/04C08L5/08
Inventor 朱新远冯汉林许冠哲朱丹金鑫吴筱昆童刚生冯贻东
Owner SHANGHAI JIAO TONG UNIV
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