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Composite active lyophilized powder and preparation method and application thereof

A freeze-dried powder, active technology, applied in the field of medicine, can solve the problems of toxic and side effects, long course of treatment, discomfort, etc., and achieve the effects of no waste liquid discharge, simple preparation method and low energy consumption

Pending Publication Date: 2019-09-06
通化鑫业生物科技研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, western medicines such as ranitidine, omeprazole, and bismuth pectin are usually used for treatment, but there are long courses of treatment, discomfort and side effects after taking the medicine. The market is in urgent need of new anti-ulcer drugs with high efficiency and low toxicity. Biologically active natural medicines are gaining more and more attention

Method used

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  • Composite active lyophilized powder and preparation method and application thereof
  • Composite active lyophilized powder and preparation method and application thereof
  • Composite active lyophilized powder and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 proposes a kind of compound roxburghii active freeze-dried powder orally disintegrating tablet, and its preparation method comprises the steps:

[0025] Take 10 kg of fresh Rosa roxburghii and 2 kg of fresh blueberries. The above raw materials are cleaned with distilled water and crushed into 60-100 mesh particles. After centrifugal separation, it is concentrated by a reverse osmosis concentrator (Hefei Zhixuan Membrane Separation Technology Co., Ltd.) to obtain a concentrate and reverse osmosis water. Reverse osmosis water is recycled as extraction solvent to realize green production. The concentrated solution is freeze-dried to obtain the active freeze-dried powder of the compound Rosa roxburghii, which weighs 1.3 kg.

Embodiment 2

[0027] Embodiment 2 proposes a kind of compound roxburghii active freeze-dried powder orally disintegrating tablet, and its preparation method comprises the steps:

[0028] Get 200 grams of compound Rosa roxburghii active freeze-dried powder powder, 100 grams of microcrystalline cellulose (MCC), 20 grams of mannitol, 25 grams of cross-linked carboxymethyl konjac starch sodium, the above-mentioned materials are fully mixed in a three-dimensional mixer, To obtain the mixture, add 6ml of absolute ethanol to the mixture to make a soft material, extrude and granulate with a 20-mesh sieve, dry at a constant temperature at 30°C for 8 hours, granulate with a 20-mesh sieve, add 5 grams of magnesium stearate, mix well, and press into Each tablet weighs 500mg orally disintegrating compound Rosa roxburghii active freeze-dried powder.

[0029] Determination of disintegration time limit of compound Rosa roxburghii active freeze-dried powder orally disintegrating tablets

[0030] Referring ...

Embodiment 3

[0032] Embodiment 3 proposes a kind of composite roxburghii active freeze-dried powder tablet, and its preparation method comprises the steps:

[0033] Prepare compound Rosa roxburghii active freeze-dried powder tablet according to the following ratio:

[0034]

[0035] After uniformly mixing the active lyophilized prickly pear powder and starch, making granules, adding magnesium stearate and talcum powder, mixing uniformly, pressing into 10000 tablets.

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Abstract

The invention relates to composite active lyophilized powder and a preparation method and application thereof. The preparation method comprises the steps of washing raw materials, crushing, extracting, carrying out centrifugal separation, concentrating with a reverse osmosis concentrator, collecting concentrate, and lyophilizing the concentrate to obtain the composite active lyophilized powder, wherein the raw materials at least include one of fresh Rosa roxbunghii fruit and fresh blueberry. During extraction, the weight ratio of the raw materials to water is 1:(3-5). The preparation method ofthe composite active lyophilized powder is simple, has low energy consumption, enables a solvent to be recycled, is free of wastewater emission during production, and allows active ingredients to bepreserved completely; the composite active lyophilized powder prepared via the preparation method has the significant effects of treating oral ulcers, treating gastric ulcers and treating other pepticulcers, is applicable to the development of drugs and health-care foods and has good commercial prospect and medical prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composite active freeze-dried powder, a preparation method and application thereof. Background technique [0002] Recurrent oral ulcer is a disease with the highest incidence rate among oral mucosal diseases. The common cold, indigestion, mental stress, depression and other conditions can occasionally cause the occurrence of the disease, and it is more likely to occur on the lips, cheeks, tongue edge, etc. , can appear anywhere on the mucous membrane. [0003] Modern medicine believes that recurrent oral ulcers are first closely related to immunity. Some patients show immunodeficiency, and some patients show autoimmune reaction; secondly, it is related to heredity. In clinical practice, the onset of recurrent oral ulcers has obvious family genetic tendency. Recurrent aphthous ulcers, their children are more susceptible to the disease than the average person; in a...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K9/20A61K36/738A61K36/45A61P1/02A61P1/04A23L33/105A23P10/40
CPCA61K9/19A61K9/0056A61K9/2059A61K36/738A61K36/45A61P1/02A61P1/04A23L33/105A23P10/40Y02A50/30
Inventor 徐从立张家秋
Owner 通化鑫业生物科技研发有限公司
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