Gold nanoparticle with Gram selectivity and modified with phenylboronic acid and derivatives of phenylboronic acid and preparation method and application of gold nanoparticle

Abstract

The invention provides a gold nanoparticle with Gram selectivity and modified with phenylboronic acid and derivatives of the phenylboronic acid, and further provides a preparation method and application of the gold nanoparticle. The gold nanoparticle modified with the phenylboronic acid and the derivatives of the phenylboronic acid has high biological safety, and the identification and targeting of bacteria are improved; the stability between small molecules and the gold nanoparticle is ensured, the preparation method is simple, the bacteria are not prone to being induced to produce drug resistance, the antibacterial activity of Gram-negative bacterium selection and identification is achieved, and the antibacterial effect against drug-sensitive strains and multi-drug resistant strains is obvious; and the gold nanoparticle co-modified with the two ligands has a broad-spectrum antibacterial effect, synthesized particles are stable and easy to store, and the potential for large-scale production and broad clinical application prospects are achieved.

Description

Technical field [0001] The invention belongs to the field of nano biomaterials, and specifically relates to a gold nanoparticle modified with phenylboronic acid and its derivatives with Gram selectivity, and a preparation method and application thereof. Background technique [0002] Gram-negative bacteria (e.g. Escherichia coli) can cause infections of the urinary tract, gastrointestinal and lungs, while gram-positive bacteria (e.g. Staphylococcus aureus) can cause skin and cartilage infections. With the reduction in the efficiency of conventional antibiotics and the intensification of clinical infections, bacterial infections and antibiotic resistance have become major issues of global concern. Therefore, there is an urgent need to develop a new generation of antibacterial agents that are selective for Gram bacteria and are not easy to induce bacterial resistance. Antibacterial agents designed by exchanging ligands have been used to prepare many types of antibacterial agents, i...

AI Technical Summary

Problems solved by technology

At present, the prior art discloses a composite nano-antibacterial agent with bacteria-specific recognition ability and its application. Bacillus influenzae and Staphylococcus aureus have selective recognition ability, but nano-silver is unstable and has strong toxicity to the human body. The US FDA has explicitly banned the use of nano-silver in medical applications. restricted

The prior art also discloses a composition for preparing antibacterial polyurethane, antibacterial polyurethane and a preparation method thereof, which can selectively kill Gram-positive bacteria, but the raw material components include polymer diol, diisocyanate, Chain extender and benzisothiazoline, the composition is complex, and the influence between various components is not clear

The prior art discloses a selective bactericide of composite nanoparticles and its preparation and application. The antibiotic is modified by a chemical cross-linking agent to achieve selective sterilization, but it is unavoidable that the use of antibiotics will lead to the emergence of bacterial drug resistance, and there is an induced The hidden danger of superbugs

The prior art discloses a myrrh alkane-type sesquiterpene compound and its preparation method and its application as a selective antibacterial agent. It has the activity of inhibiting various bacteria, but it needs to undergo fermentation culture, filtration, concentration, extraction, and chromatographic separation. and the eluent are concentrated, the product preparation process is complicated, and the degree of purification is difficult to determine

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