Adhesion thermo-sensitive hydrogel of composite bioglass and preparation method and application of adhesion thermo-sensitive hydrogel

A temperature-sensitive hydrogel and bioglass technology, applied in the field of biomedical materials, can solve the problems of unfavorable wound healing, poor tissue adhesion and antibacterial performance, toxic and side effects, etc., and achieve improved biological activity, water solubility, good dispersibility, The effect of large specific surface area

Active Publication Date: 2019-11-08
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional skin wound dressings include gauze, bandages, etc., but they all have certain limitations. They cannot accelerate wound healing and fully meet the needs of chronic wound healing. At the same time, they will also adhere to wound secretions, which is easy to cause secondary damage when changing dressings
A variety of hydrogel dressing products developed in recent years have excellent soft and wet characteristics and biocompatibility similarity, which can improve wound healing and skin repair to a certain extent, but most of the products are tissue adhesive and antibacterial. poor performance
For example, some hydrogel products with low tissue adhesion can fill irregular wounds in the early stage of application, but due to their poor mechanical properties and weak adhesion, they are easy to flow away under external force, which is not conducive to wound healing
Traditionally, adding antibiotics, antimicrobial peptides or antibacterial drugs containing nano-Ag to enhance the antibacterial performance of hydrogel products is often accompanied by certain toxic and side effects.

Method used

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  • Adhesion thermo-sensitive hydrogel of composite bioglass and preparation method and application of adhesion thermo-sensitive hydrogel
  • Adhesion thermo-sensitive hydrogel of composite bioglass and preparation method and application of adhesion thermo-sensitive hydrogel
  • Adhesion thermo-sensitive hydrogel of composite bioglass and preparation method and application of adhesion thermo-sensitive hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] A preparation method of bioglass, comprising:

[0073] Medium SiO by Bioglass 2 :CaO:P 2 o 5 The molar ratio was 80:16:4 for the preparation. With 125mL of anhydrous ethanol / water mixed solution with a volume ratio of 16:5 as solvent, add 4g of dodecylamine, stir until completely dissolved, then add 16mL of ethyl orthosilicate and 1.22mL of triethyl phosphate dropwise, and finally Add 3.39g of calcium nitrate tetrahydrate and stir magnetically at 35°C for 3 hours to obtain bioglass sol. Collect the white precipitate, wash it alternately with anhydrous ethanol and deionized water for 3 times, and dry it in vacuum to obtain a white lump; then transfer the white lump to a crucible for high-temperature calcination, and maintain the heating rate at 2°C / min to 650 °C for 3 hours; after high-temperature calcination, natural cooling to obtain a powdery white powder, which is rice bioactive glass.

[0074] Characterize with the bioglass prepared by the above-mentioned embod...

Embodiment 2

[0077] A method for preparing an adhesive thermosensitive hydrogel of composite bioglass, comprising the following steps:

[0078] At normal temperature, chitosan (CS) (purchased from Sigma-Aldrich, product number: 448877) was dissolved in the acetic acid solution of 87.5mmol / L, magnetically stirred at room temperature for 12h to obtain 1-1.5wt% CS solution, and then Add 1.16 mL of an aqueous solution of 2,3-epoxypropyltrimethylammonium chloride (GMTAC) (9.25-9.30 mmol / L) within 1 h, wherein the molar weight of GMTAC is 1.5-1.6 times that of the amino group on chitosan. The reaction was stirred at 55° C. for 18 hours, and after the reaction was completed, quaternized chitosan (QCS) was obtained after dialysis and freeze-drying. After testing, the yield of the QCS is greater than 80%, and its grafting rate can reach 45-47% according to NMR;

[0079] Under normal temperature conditions, stir and dissolve the prepared QCS in an aqueous solution to obtain an aqueous solution of a...

Embodiment 3

[0084] A method for preparing an adhesive thermosensitive hydrogel of composite bioglass, comprising the following steps:

[0085] At room temperature, dissolve chitosan in 87.5 mmol / L acetic acid solution, stir magnetically at room temperature for 12 hours to obtain a CS solution with a mass concentration of about 1.5%, and then slowly add 1.16 mL of 2,3-epoxypropyltrimethyl chloride An aqueous solution of ammonium chloride (GMTAC) (9.25-9.30 mmol / L), wherein the molar weight of GMTAC is 1.5-1.6 times that of the amino group on chitosan. The reaction was stirred at 60°C for 20 hours, and after the reaction was completed, the quaternized chitosan (QCS) was obtained after dialysis and freeze-drying. After testing, the yield of the QCS is greater than 80%.

[0086] Under normal temperature conditions, stir and dissolve the prepared QCS in an aqueous solution to obtain a 0.08 g / mL aqueous solution of QCS, adjust its pH to 4.5 with 2M HCl solution, add dopamine hydrochloride, sti...

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Abstract

The embodiment of the invention provides an adhesion thermo-sensitive hydrogel of composite bioglass. The adhesion thermo-sensitive hydrogel is prepared from the following components in percentage byweight: 25-40% of PDLLA-PEG-PDLLA triblock polymer, 1-1.25% of dopamine modified quaternized chitosan, 1-5% of bio-glass and the balance of deionized water. The adhesion thermo-sensitive hydrogel of the composite bioglass has good adhesion, antibacterial property and biocompatibility. The adhesion thermo-sensitive hydrogel of the composite bioglass can self-adhere to the surface of the skin wound,and is beneficial for promoting skin regeneration and wound repair. The invention further provides a preparation method and application of the adhesion thermo-sensitive hydrogel of the composite bioglass. The preparation method is simple in process and high in yield, and is suitable for large-scale industrial production. The adhesion thermo-sensitive hydrogel of the composite bioglass prepared bythe preparation method has good adhesion, antibacterial property and biocompatibility, and has broad application prospects in the preparation of drugs for skin wound healing.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an adhesive temperature-sensitive hydrogel of composite bioglass and its preparation method and application. Background technique [0002] The skin is the largest organ of the human body, and it is easily damaged due to its large area exposed to the external environment. Traditional skin wound dressings include gauze, bandages, etc., but they all have certain limitations. They cannot accelerate wound healing and fully meet the needs of chronic wound healing. At the same time, they will also adhere to wound secretions, which is easy to cause secondary damage when changing dressings . A variety of hydrogel dressing products developed in recent years have excellent soft and wet characteristics and biocompatibility similarity, which can improve wound healing and skin repair to a certain extent, but most of the products are tissue adhesive and antibacterial. Poor perfor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61K9/06A61K47/34A61K47/36A61K47/02A61K47/04A61P17/02C08L67/04C08L5/08C08K7/20C08J3/075C08B37/08
CPCA61K9/06A61K47/02A61K47/34A61K47/36A61L26/0004A61L26/0019A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L2300/236A61L2300/404A61L2300/412A61L2400/06A61L2400/12A61P17/02C08B37/003C08J3/075C08J2367/04C08J2405/08C08K2201/011C08L67/04C08L71/02C08L5/08C08K7/20
Inventor 赵晓丽郑志强潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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