Application of wahlenbergia marginata extract to preparation of medicines for treatment or prevention of inflammatory bowel diseases

A technology of inflammatory bowel disease and blue ginseng, applied in the field of medicine, to reduce the generation of oxygen free radicals ROS and malondialdehyde (MDA), reduce weight and improve intestinal epithelial barrier function

Inactive Publication Date: 2019-11-12
CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its root or whole herb is widely used as a kind of ethnic minority medicine in the treatment of respiratory diseases such as cold, lung deficiency cough, bronchopneumonia in children, malnutrition in children, toothache, malaria, hypertension, etc., but it has not been reported to be used for inflammatory bowel disease. disease treatment

Method used

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  • Application of wahlenbergia marginata extract to preparation of medicines for treatment or prevention of inflammatory bowel diseases
  • Application of wahlenbergia marginata extract to preparation of medicines for treatment or prevention of inflammatory bowel diseases
  • Application of wahlenbergia marginata extract to preparation of medicines for treatment or prevention of inflammatory bowel diseases

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preparation example Construction

[0048] One of the technical schemes of the present invention is to provide a preparation method for the extract of blue ginseng for preventing and treating inflammatory bowel disease, which specifically includes the following three steps: mechanically pulverize the dried and moldy blue ginseng whole herb into powder to obtain blue flower Ginseng powder; with a mass ratio of 1:4-20, the blue ginseng powder and water or organic solvents of different polarities are added to the Soxhlet extractor, soaked at reflux temperature for 4-8 hours, and extracted repeatedly for 2 -5 times to obtain the blue ginseng extract; then vacuum dry the blue ginseng extract at room temperature to obtain a solid powdered blue ginseng extract. The required organic solvent includes but not limited to at least one of diethyl ether, dichloromethane, chloroform, ethyl acetate, acetonitrile, ethanol, and methanol.

[0049] The second technical solution of the present invention is that the above-mentioned blu...

Embodiment 1

[0056] The preparation method of blue flower ginseng extract:

[0057] Mechanically pulverize the dried blue ginseng into powder, screen through a sieve to obtain a powder with an average diameter of about 0.8 mm, weigh 10 grams of blue ginseng powder and put it into a Soxhlet extractor, add 100 ml of methanol to a round bottom flask, and then heat the round bottom Flask, solvent evaporation, condensation, leaching, reflux, extract at reflux temperature for 6 hours, collect the blue flower ginseng extract in the round bottom flask, vacuum dry under normal temperature, obtain 2.18 grams of gray-green solid sheet-shaped blue flower ginseng methanol extract, get The rate was 21.8%.

Embodiment 2

[0059] The dried blue ginseng is mechanically crushed into powder, screened through a sieve to obtain a powder with an average diameter of about 0.8mm, weigh 10 grams of blue ginseng powder and put it into a Soxhlet extractor, add 100 ml of dichloromethane into a round bottom flask, and then heat Round bottom flask, solvent evaporation, condensation, leaching, reflux, extract at reflux temperature for 5 hours, collect the extract of ginseng in the round bottom flask, and dry it under vacuum at room temperature to obtain the dichloromethane extract of flaky blue ginseng in gray-green solid form 2.24 g, yield 22.4%.

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Abstract

The invention relates to the field of medicines, in particular to an application of a wahlenbergia bmarginata extract to preparation of medicines for treatment or prevention of inflammatory bowel diseases. Natural plant, namely wahlenbergia marginata, is used as the raw material, and through a soxhlet method, an effective active component namely a wahlenbergia marginata extract in the wahlenbergiamarginata can be extracted and can be used for preventing and treating application to the inflammatory bowel diseases. The wahlenbergia marginata plant extract can be used as a safe and effective treatment drug for inflammatory bowel diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of blue ginseng extract in the preparation of medicines for treating or preventing inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (Inflammatory Bowel Disease, IBD) is a chronic, idiopathic intestinal inflammatory disease involving the ileum, colon, and rectum, mainly including Crohn's disease (Crohn Disease, CD) and ulcerative colitis ( Ulcerative Colitis, UC). The pathological features are mainly continuous or discontinuous inflammatory reactions in the colonic mucosa and submucosa, and the clinical manifestations are abdominal pain, diarrhea, blood in the stool, fatigue, malnutrition, and weight loss. In recent years, the incidence and prevalence of inflammatory bowel disease have increased year by year, and its clinical treatment costs have continued to increase. Some patients may experience intestinal bleeding, intestinal perforat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/34A61P1/00A61P1/04
CPCA61K36/34A61P1/00A61P1/04
Inventor 刘星万敬员刘学乾
Owner CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV
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