Oral supplement fluid salt powder and preparation method thereof

A technology for rehydration salts and prescriptions, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, active ingredients of alkaline/alkaline earth metal chlorides, etc., can solve the problems of unfavorable children taking, no clear improvement, and high sodium and glucose content. , to achieve the effect of reducing the necessity, reducing the osmotic pressure, and reducing the amount of feces

Pending Publication Date: 2019-11-26
SICHUAN TAIPINGYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these two types of drugs are not suitable for children because of the high sodium and glucose content
[0004] Moreover, for the preparation process, there is no clear improvement

Method used

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  • Oral supplement fluid salt powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: make supplementary salt powder of 5 grams / bag specification, and its consumption of every bag is as follows:

[0028] materials unit dose Sodium chloride 0.65g potassium chloride 0.375g sodium citrate 0.825g anhydrous glucose 3.375g

[0029] After the above materials are dried, they will lose water and weight, so that the whole bag packaging is close to 5g.

Embodiment 2

[0030] Embodiment two: the production specification is 5 grams / bag of supplementing salt powder, and the output is that the consumption of 1000 bags is as follows:

[0031] materials Dosage Sodium chloride 0.6506kg potassium chloride 0.3765kg sodium citrate 0.8257kg anhydrous glucose 3.3777kg

[0032] After the above materials are dried, they will lose water and lose weight, and they will be sub-packaged after processing, so that the packaging in small bags will approach 5g after sub-packaging.

Embodiment 3

[0033] Embodiment 3: The preparation method of oral rehydration salt powder.

[0034] 1. Crushing process

[0035] Take sodium chloride, potassium chloride, and sodium citrate respectively, and put them on a 30B universal grinder with an 80-mesh sieve to grind them separately, set aside, calculate the loss rate, and use a fast moisture meter to measure the moisture content of the crushed material to determine whether subsequent drying is required .

[0036] 2. Mixing process

[0037] (1) Equipment / Consumables

[0038] name factory model 3D Motion Mixer Changzhou Xuanyu Drying Equipment Co., Ltd. SYH-10

[0039] (2) mixed

[0040] Put the weighed 35% anhydrous glucose into the mixer, add the weighed sodium chloride, potassium chloride and sodium citrate in the prescribed amount, put each material into the three-dimensional motion mixer in sequence, close the feeding port, and start The mixer was turned on and mixed for 10 minutes. Observing the ...

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PUM

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Abstract

The present invention discloses oral supplement fluid salt powder and a preparation method thereof. The oral supplement fluid salt powder is composed of sodium chloride, potassium chloride, sodium citrate and anhydrous glucose. The preparation method is composed of a pulverizing step, a mixing step and a sub-packaging step; the pulverizing step is respectively pulverizing sodium chloride, potassium chloride and sodium citrate; and the mixing step is putting anhydrous glucose within half of a prescription amount into a mixer, adding the prescription amount of the sodium chloride, potassium chloride and sodium citrate, starting the mixer to start mixing, and taking out the drug powder after mixing to conduct sieving and dispersing; and adding the sieved powder to the mixer, adding the remaining anhydrous glucose, and starting the machine again to complete mixing. The preparation method reduces content of sodium and glucose, thus lowers osmotic pressure, and is more suitable for dehydration prevention of infants and young children and fluid supplement of mild to moderate dehydration without circulation failure.

Description

technical field [0001] The present invention relates to a medicine for human use. Background technique [0002] Oral rehydration salt powder is a national essential medicine, and it is a hypotonic ORS formula announced by WHO. It regulates intestinal water and electrolyte metabolism balance, replenishes fluid and stops diarrhea. Drugs of choice for the treatment of diarrheal diseases used by countries. In addition to supplementing water, sodium and potassium, it still has a therapeutic effect on acute diarrhea. This product contains glucose, and the intestinal mucosa can absorb a certain amount of sodium ions while absorbing glucose, thereby increasing the absorption of intestinal juice by the intestinal mucosa. [0003] Oral rehydration salt powder is now publicly available as type 1 and type 2. However, these two types of drugs are not suitable for children because of their high sodium and glucose content. [0004] Moreover, for the preparation process, there is no cle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/14A61P3/12A61P1/12A61K31/194A61K31/7004
CPCA61K33/14A61K31/194A61K31/7004A61K9/14A61P3/12A61P1/12A61K2300/00
Inventor 张加宇许艳春文娟王利华
Owner SICHUAN TAIPINGYANG PHARMA
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