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Micro-nano magnesium hydride antibacterial and anti-inflammatory wound dressing

A wound dressing, antibacterial and anti-inflammatory technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of poor biological safety and biocompatibility, weak inhibition of Gram-negative bacteria, poor antifungal and mold effects, etc. , to achieve superior biological safety and compatibility, significant bactericidal effect, and prevent wound adhesion

Pending Publication Date: 2019-12-13
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the raw material of silver-based antibacterial agents is expensive, the cost is high, the anti-fungal and mold effects are poor, and silver is not an essential element for the human body, the biological safety and biocompatibility in the body are poor, and the use is also harmful to environmental safety.
The antibacterial ability of chitin / chitosan natural antibacterial agents is strongly dependent on the pH of the surrounding environment, and the inhibitory ability against Gram-negative bacteria is weak
However, common bactericidal drugs are prone to drug resistance, and often have side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0026] Nano-magnesium hydride with a particle size of 200-1000nm is uniformly dispersed in an absolute ethanol solution containing 1% silane coupling agent at 10% w / v, and the activated natural gauze is soaked in the above solution for 15 minutes and then pulled out. After drying at ℃, continue vacuum drying at room temperature for 24 hours. The amount of corresponding magnesium hydride micro-nano powder loaded on the dressing matrix is ​​50 μg / cm2 dressing; the amount of hydrogen gas generated when the dressing is used is 0.086mL / cm2 dressing.

[0027] The above-mentioned dressing was subjected to an animal (rabbit) body antibacterial test, and the bacteriostatic rate to Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli within 72 hours all reached more than 95%. The rate of wound healing was about 25% faster than that of the control group polyethylene-based non-woven dressing.

Embodiment 3

[0029] Micronano magnesium hydride with a particle size of 500nm-10μm is uniformly dispersed in absolute ethanol at 15% w / v to form a solution, and the above solution is evenly sprayed on the surface of the chitosan film dressing base, dried at 50°C and then vacuumed at room temperature Let dry for 24 hours. The amount of the corresponding magnesium hydride micro-nano powder loaded on the dressing matrix is ​​350 μg / cm2 dressing; the amount of hydrogen gas generated when the dressing is used is 0.6mL / cm2 dressing.

[0030] The results of in vitro antibacterial experiments showed that the 24-hour bacteriostatic rates of gram-positive Staphylococcus aureus and gram-negative Escherichia coli were 78% and 63% respectively for the chitosan film dressing matrix not sprayed with nano-magnesium hydride, and the sprayed nano-magnesium hydride After magnesium hydride, the antibacterial rate all rose to 99%. The fibroblast toxicity test in vitro shows that the toxicity is grade 0-1, and...

Embodiment 4

[0032] Disperse nano-magnesium hydride with a particle size of 100-500nm at 5% w / v and nano-silver with a particle size of 20-50nm at 0.5% w / v in absolute ethanol containing 1% silane coupling agent, and make the above solution uniform Drop-coated on the base of the foamed polymer film dressing, dried at 50°C and then dried under vacuum at room temperature for 24 hours. The amount of the corresponding magnesium hydride micro-nano powder loaded on the dressing matrix is ​​0.8mg / square centimeter dressing; the amount of hydrogen gas generated when the dressing is used is 1.4mL / square centimeter dressing.

[0033] The above-mentioned dressing was subjected to an animal (rabbit) body antibacterial test, and the bacteriostatic rate to Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli within 72 hours all reached more than 99.9%.

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Abstract

The invention discloses a micro-nano magnesium hydride antibacterial and anti-inflammatory wound dressing. The wound dressing comprises an effective antibacterial and anti-inflammatory component magnesium hydride MgH2 micro-nano powder, an auxiliary material and a dressing matrix, and magnesium hydride micro-nano powder is uniformly loaded and coated on the surface and / or inside the dressing matrix. The magnesium hydride micro-nano powder absorbs moisture immediately when encountering a wound exudate, reacts and is converted into micro-nano magnesium hydroxide particles, meanwhile, local alkalinity is caused, and the magnesium hydride micro-nano powder has broad-spectrum bactericidal activity without illumination induction and good biocompatibility. Meanwhile, hydrogen released by the reaction has non-toxic and anti-inflammatory characteristics and has a certain effect of preventing wound adhesion. The dressing is convenient to store and use, safe, environment-friendly, antibacterial,anti-inflammatory and anti-infection, and is beneficial to wound repair.

Description

technical field [0001] The invention relates to a dressing for medical wounds and wounds, in particular to a safe and environment-friendly micronano magnesium hydride dressing with antibacterial and anti-inflammatory functions. Background technique [0002] After the human skin is injured, there will be different degrees of tissue necrosis and blood vessel rupture and bleeding in the local wound, and an inflammatory reaction will appear within a few hours, manifested as hyperemia, serous exudation and leukocyte exudation. The body has a series of biochemical programs that attempt to repair and rebuild. The basic processes include hemostasis, inflammation, cell proliferation, and maturation and remodeling. During this repair period, medical dressings often play an important role as a wound cover: they can temporarily replace part of the skin barrier and provide a favorable microenvironment for wound healing; at the same time, they can control wound secretions, stop bleeding, ...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/42A61L15/44A61L15/46A61L15/50
CPCA61L15/18A61L15/42A61L15/44A61L15/46A61L15/50A61L2300/404A61L2300/41A61L2300/102A61L2300/424A61L2300/412A61L2400/12
Inventor 袁广银裴佳丁文江
Owner SHANGHAI JIAO TONG UNIV
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