Preparation method of guided tissue regeneration membrane for tooth restoration
A technology that guides tissue regeneration and tooth restoration. It is applied in tissue regeneration, medical science, and prostheses. It can solve the problems of poor mechanical properties, long preparation cycle, and high cost of degradable membranes, and achieve improved biocompatibility and enhanced biocompatibility. Compatibility, effect of improving mechanical properties
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Embodiment 1
[0039] A preparation method of guided tissue regeneration membrane for tooth restoration, which consists of the following steps:
[0040] (1) Dissolve polylactide glycolide copolymer (PLGA, with a GA / LA molar ratio of 7:3) in chloroform, disperse ultrasonically for 20 minutes, pour the solution into a petri dish, with a gradient of -80~-60℃ freezing;
[0041] (2) Dissolve natural polymer material collagen in 1% acetic acid solution, add 0.5wt% nano-hydroxyapatite at the same time, disperse ultrasonically for 30 minutes, and then pour the solution into a petri dish containing PLGA solution, -80 ~-40℃ gradient freezing;
[0042] (3) Put the petri dish into the freeze dryer, freeze-dry for 24 hours, and get the guided tissue regeneration membrane.
[0043] The aforementioned guided tissue regeneration membrane is a composite membrane structure of upper and lower layers, with an average pore size of 40 microns, a porosity of 75%, and a connectivity rate of 89%. The upper membrane is a m...
Embodiment 2
[0045] A preparation method of guided tissue regeneration membrane for tooth restoration, which consists of the following steps:
[0046] (1) Dissolve polycaprolactone (PCL, molecular weight 100,000) in dichloromethane, ultrasonically disperse for 30 minutes, pour the solution into a petri dish, and freeze with a gradient of -60~-40℃;
[0047] (2) Dissolve natural macromolecule silk fibroin in water, add 2wt% tricalcium phosphate at the same time, disperse ultrasonically for 60 minutes, then pour the solution into a petri dish containing PCL solution, and freeze with a gradient of -60~-20℃;
[0048] (3) Put the petri dish into the freeze dryer, freeze-dry for 36 hours, and get the guided tissue regeneration membrane.
[0049] The aforementioned guided tissue regeneration membrane is a composite membrane structure of upper and lower layers, with an average pore diameter of 100 microns, a porosity of 85%, and a connection rate of 90%. The upper membrane is a macroporous layer with a por...
Embodiment 3
[0051] A preparation method of guided tissue regeneration membrane for tooth restoration, which consists of the following steps:
[0052] (1) Dissolve polycaprolactone (PCL, molecular weight 100,000) in dichloromethane, ultrasonically disperse for 30 minutes, pour the solution into a petri dish, and freeze with a gradient of -60~-40℃;
[0053] (2) Dissolve collagen (extracted from pig skin type I collagen) in 1% acetic acid, add 4% active bioglass, and disperse ultrasonically for 30 minutes, then pour the solution into a petri dish containing PCL solution, -60~ Gradient freezing at -20℃;
[0054] (3) Put the petri dish into the freeze dryer, freeze-dry for 24 hours, and get the guided tissue regeneration membrane.
[0055] The aforementioned guided tissue regeneration membrane is a composite membrane structure of upper and lower layers, with an average pore diameter of 110 microns, a porosity of 87%, and a connectivity rate of 93%. The upper membrane is a macroporous layer with a por...
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