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Preparation method of guided tissue regeneration membrane for tooth restoration

A technology that guides tissue regeneration and tooth restoration. It is applied in tissue regeneration, medical science, and prostheses. It can solve the problems of poor mechanical properties, long preparation cycle, and high cost of degradable membranes, and achieve improved biocompatibility and enhanced biocompatibility. Compatibility, effect of improving mechanical properties

Active Publication Date: 2019-12-13
苏州高哲斯环境新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, in terms of effect, it is better to choose a degradable film. However, the existing degradable film has a long production cycle, low efficiency, and high cost; moreover, the existing degradable film has poor mechanical properties, and in practice Applications often have problems with structural collapse resulting in inability for cells to adhere and grow

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  • Preparation method of guided tissue regeneration membrane for tooth restoration
  • Preparation method of guided tissue regeneration membrane for tooth restoration
  • Preparation method of guided tissue regeneration membrane for tooth restoration

Examples

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Embodiment 1

[0039] A preparation method of guided tissue regeneration membrane for tooth restoration, which consists of the following steps:

[0040] (1) Dissolve polylactide glycolide copolymer (PLGA, with a GA / LA molar ratio of 7:3) in chloroform, disperse ultrasonically for 20 minutes, pour the solution into a petri dish, with a gradient of -80~-60℃ freezing;

[0041] (2) Dissolve natural polymer material collagen in 1% acetic acid solution, add 0.5wt% nano-hydroxyapatite at the same time, disperse ultrasonically for 30 minutes, and then pour the solution into a petri dish containing PLGA solution, -80 ~-40℃ gradient freezing;

[0042] (3) Put the petri dish into the freeze dryer, freeze-dry for 24 hours, and get the guided tissue regeneration membrane.

[0043] The aforementioned guided tissue regeneration membrane is a composite membrane structure of upper and lower layers, with an average pore size of 40 microns, a porosity of 75%, and a connectivity rate of 89%. The upper membrane is a m...

Embodiment 2

[0045] A preparation method of guided tissue regeneration membrane for tooth restoration, which consists of the following steps:

[0046] (1) Dissolve polycaprolactone (PCL, molecular weight 100,000) in dichloromethane, ultrasonically disperse for 30 minutes, pour the solution into a petri dish, and freeze with a gradient of -60~-40℃;

[0047] (2) Dissolve natural macromolecule silk fibroin in water, add 2wt% tricalcium phosphate at the same time, disperse ultrasonically for 60 minutes, then pour the solution into a petri dish containing PCL solution, and freeze with a gradient of -60~-20℃;

[0048] (3) Put the petri dish into the freeze dryer, freeze-dry for 36 hours, and get the guided tissue regeneration membrane.

[0049] The aforementioned guided tissue regeneration membrane is a composite membrane structure of upper and lower layers, with an average pore diameter of 100 microns, a porosity of 85%, and a connection rate of 90%. The upper membrane is a macroporous layer with a por...

Embodiment 3

[0051] A preparation method of guided tissue regeneration membrane for tooth restoration, which consists of the following steps:

[0052] (1) Dissolve polycaprolactone (PCL, molecular weight 100,000) in dichloromethane, ultrasonically disperse for 30 minutes, pour the solution into a petri dish, and freeze with a gradient of -60~-40℃;

[0053] (2) Dissolve collagen (extracted from pig skin type I collagen) in 1% acetic acid, add 4% active bioglass, and disperse ultrasonically for 30 minutes, then pour the solution into a petri dish containing PCL solution, -60~ Gradient freezing at -20℃;

[0054] (3) Put the petri dish into the freeze dryer, freeze-dry for 24 hours, and get the guided tissue regeneration membrane.

[0055] The aforementioned guided tissue regeneration membrane is a composite membrane structure of upper and lower layers, with an average pore diameter of 110 microns, a porosity of 87%, and a connectivity rate of 93%. The upper membrane is a macroporous layer with a por...

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Abstract

The invention discloses a preparation method of a guided tissue regeneration membrane for tooth restoration, wherein the preparation method comprises the following steps: (1) dissolving a synthetic polymer material in an organic solvent, uniformly dispersing, pouring the solution into a culture dish, and freezing; and obtaining a first layer structure; (2) dissolving a natural polymer material inan organic solvent, adding inorganic bioactive particles, uniformly dispersing, casting the mixed solution onto the first layer structure, and then freezing; and obtaining a composite layer structure;and (3) carrying out freeze drying on the composite layer structure obtained in the step (2). The synthetic polymer and natural polymer composite material is adopted, so that the biocompatibility ofthe composite membrane is improved while the mechanical property of the composite membrane is improved; a gradient temperature freezing mode is adopted in a matched mode, distribution of pore structures on the longitudinal structure of the composite membrane is regulated and controlled, the pore structure with the gradient structure is formed, adhesion and growth of cells are better facilitated, and a remarkable effect is achieved.

Description

Technical field [0001] The invention relates to a method for preparing a guided tissue regeneration membrane for tooth restoration. Background technique [0002] Periodontal disease is one of the common oral diseases in humans. In the early stage of the disease, the structure of periodontal supporting tissues is destroyed. As the disease worsens, the periodontal structure is gradually lost, causing tooth loss. In response to this disease, guided tissue regeneration has emerged. Guided Tissue Regeneration (GTR) is a surgical method to place a physical barrier to selectively separate different periodontal tissues, prevent the growth of gingival epithelium and gingival connective tissue to the root surface, create space, and induce periodontal The periodontal ligament cells with tissue regeneration potential move coronally and grow and differentiate to regenerate the periodontal ligament, alveolar bone, and cementum, and form a new attachment technology to the periodontal. Since N...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/56A61L27/58A61L27/46A61L27/44
CPCA61L27/18A61L27/446A61L27/46A61L27/56A61L27/58A61L2430/12C08L67/04
Inventor 奚桢浩韩宇晴宋超波张嘉鹏岑莲陆尔奕崔立宇
Owner 苏州高哲斯环境新材料有限公司
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