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Modifier, its preparation method, use method and medical material

A technology for modifiers and metal substrates, applied in the field of medical materials and modifiers, can solve the problems of weak binding between polymers and substrates, limited application range of substrates, unfavorable long-term use, etc., and achieve good cell compatibility , Conducive to modification, to avoid the effect of pollution

Active Publication Date: 2020-11-24
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface grafting method is that the polymer is connected with the groups on the surface of the substrate through chemical bonds, but the requirements for the substrate are relatively high, the surface of the substrate needs to be activated and modified, and the reaction conditions must be strictly controlled. The process is cumbersome and the preparation cycle is relatively short. long
The physical immobilization method is to immobilize the polymer on the surface of the substrate through the effect of physical non-covalent bond through van der Waals force, hydrogen bond or electric charge. The modification of charges or active groups limits the scope of application of the substrate, and the binding force between the polymer and the substrate is weak, and the polymer is easy to fall off from the substrate, which is not conducive to long-term use

Method used

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  • Modifier, its preparation method, use method and medical material
  • Modifier, its preparation method, use method and medical material
  • Modifier, its preparation method, use method and medical material

Examples

Experimental program
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Effect test

preparation example Construction

[0066] The embodiment of the present invention also provides a preparation method of the modifier, including:

[0067] The dopamine derivative modified with an active alkenyl group and a zwitterionic compound having an active alkenyl group or a zwitterionic derivative compound modified with an active alkenyl group undergo a free radical-induced carbon-carbon addition reaction under the action of an initiator.

[0068] The modifier of the embodiment of the present invention is formed by polymerizing the dopamine derivative and the zwitterionic compound modified with a reactive alkenyl group through a carbon-carbon double bond radical polymerization reaction. The zwitterionic compound itself may have an active alkenyl group, or the alkenyl group may be modified through additional steps. The synthetic route of the modifier is short, the conditions are mild, and the functional groups of dopamine and zwitterionic compounds are not destroyed, the generation of by-products is reduced, and...

Embodiment 1

[0106] (1) Add 18g of sodium pyroborate and 8g of sodium bicarbonate into 200ml of deionized water and stir to dissolve, then filter out the insoluble matter, pour nitrogen into the aqueous solution to remove the dissolved oxygen, then add 10g of dopamine hydrochloride into the aqueous solution and stir to dissolve , Appropriately add 0.2mol / L NaOH solution to adjust the pH to above 8, and then let in nitrogen for ten minutes.

[0107] (2) Add 9.4 ml of methacrylic anhydride to 50 ml of THF and stir uniformly, and then add dropwise to the solution obtained in step (1), and then maintain a nitrogen atmosphere and stir overnight at room temperature.

[0108] (3) Adjust the pH of the solution obtained in step (2) to below 2 with 0.2 mol / L hydrochloric acid solution, and wash off the upper layer of oil droplets with a small amount of ethyl acetate. The solution was extracted and separated three times with 200 ml ethyl acetate, and the ethyl acetate phase (the first organic solvent phas...

experiment example 1

[0113] Experimental example 1 Bacteriostatic test

[0114] Collect all non-irritating saliva from healthy blood donors, collect the supernatant after centrifugation, and pasteurize at 60°C for 30 min. Sterilized PBS was added to the sterilized saliva at a ratio of 1:1 to obtain a nutrient solution. The medical material was soaked in the nutrient solution overnight at 37°C.

[0115] Streptococcus mutans UA-159 was used for antibacterial test. The strain was first in 37°C CO 2 After culturing in the incubator for 48 hours, a single strain was inoculated into BHI (brain heart infusion) medium, and then at 37℃, CO 2 Cultivate overnight under the conditions. Place the medical materials treated with nutrient solution in a 12-well plate, and inoculate each well with 2mL BHI culture medium and 40μL Streptococcus mutans suspension, at 37℃ CO 2 Cultivate in an incubator. After culturing for 15 hours, the morphology and distribution of bacteria on the surface of the medical material were c...

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Abstract

The invention discloses a modifier, which comprises a structural unit represented by a general formula (I), wherein R1 represents a direct bond or C1-C5 alkylidene or substituted alkylidene, R2 represents a direct bond or C1-C5 alkyl or substituted alkyl, R3 is a direct bond or C1-C5 alkyl or substituted alkyl, R4 is a direct bond, C1-C5 alkylidene or substituted alkylidene or C1-C5 acyloxy, R5 isa zwitterionic group, and the molecular weight of the modifier is 10-180 KDa. The invention also discloses a preparation method and a use method of the modifier, and a medical material.

Description

Technical field [0001] The invention relates to the field of functional materials, in particular to a modifier, its preparation method and use method, and medical materials. Background technique [0002] Biomedical materials are materials used to diagnose, treat, repair or replace damaged tissues and organs or enhance their functions. It is the basis for the study of artificial organs and medical devices, and has become an important branch of contemporary materials science. Especially with the vigorous development and major breakthroughs of biotechnology, biomedical materials have become a hot spot for scientists from all over the world to conduct research and development. [0003] When biomedical materials are used to treat organisms, since they are in close contact with the blood or tissues of the organisms, there are special requirements for biomedical materials, such as lubricity and antibacterial properties. Therefore, the surface of biomedical materials needs to be modified....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/36C08F230/02C08F220/38
CPCC08F220/36C08F220/38C08F230/02
Inventor 张洪玉刘思哲韩英张晓威
Owner TSINGHUA UNIV
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