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Method for continuously preparing glycine from hydroxyacetonitrile by microchannel reactor

A micro-channel reactor, hydroxyacetonitrile technology, applied in the preparation of cyanide reaction, chemical instruments and methods, preparation of organic compounds, etc., can solve the problems of difficult product separation, volatile, and inability to transport long-distance

Pending Publication Date: 2020-01-17
山西华阳集团新能股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the raw material of this method, hydrocyanic acid, is highly toxic and volatile, and cannot be transported over long distances, thus restricting its popularization and application.
[0007] (5) Aminoacetonitrile method, that is, react hydroxyacetonitrile with ammonia water to obtain aminoacetonitrile, then add inorganic base to carry out alkaline hydrolysis, then add inorganic acid to neutralize to obtain glycine reaction solution, and then obtain glycine through the steps of concentration, decolorization, crystallization and classification, The mother liquor is recycled; however, this method has the disadvantages of many side reactions, difficult product separation, and long desalination process
[0010] This process has the advantages of high atomic utilization rate, high product quality, clean and environmental protection, etc., and has great application prospects. However, the existing direct Hein process adopts the tank reactor, which has the problems of back mixing and long production cycle, and only batch tank reactor can be realized. Production, industrial continuous production has not yet been realized, so there is an urgent need for a more efficient and rapid continuous preparation of dry glycine

Method used

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  • Method for continuously preparing glycine from hydroxyacetonitrile by microchannel reactor
  • Method for continuously preparing glycine from hydroxyacetonitrile by microchannel reactor
  • Method for continuously preparing glycine from hydroxyacetonitrile by microchannel reactor

Examples

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Effect test

Embodiment 1

[0041] Using hydroxyacetonitrile, ammonium carbonate, ammonium bicarbonate and water as raw materials, mixed according to the molar ratio of 1:3:2:70, transported by the metering pump to the primary microchannel reactor at 50mL / min for synthetic hydantoin reaction, the reaction temperature 80°C, pressure 4MPa, residence time 20min. Subsequently, the synthetic reaction solution was subjected to hydantoin hydrolysis reaction in the second-stage microchannel reactor at a reaction temperature of 120°C, pressure 4MPa, and residence time 40min. The hydrolysis reaction solution is stripped, evaporated and concentrated, crystallized, separated, decolorized, and dried to obtain glycine product with a content of 99.1% and a yield of 97.3%.

Embodiment 2

[0043] Using hydroxyacetonitrile, ammonium carbonate, ammonium bicarbonate and water as raw materials, mixed according to the molar ratio of 1:3:2:70, transported by the metering pump to the primary microchannel reactor at 50mL / min for synthetic hydantoin reaction, the reaction temperature 90°C, pressure 4MPa, residence time 15min, and then, the synthetic reaction liquid was hydrolyzed in the secondary microchannel reactor, the reaction temperature was 135°C, pressure 4MPa, residence time 50min. The hydrolysis reaction solution is stripped, evaporated and concentrated, crystallized, separated, decolorized and dried to obtain a glycine product with a content of 99.3% and a yield of 97.9%.

Embodiment 3

[0045] Using hydroxyacetonitrile, ammonium carbonate, ammonium bicarbonate and water as raw materials, mixed according to the molar ratio of 1:3:2:70, transported by the metering pump to the primary microchannel reactor at 50mL / min for synthetic hydantoin reaction, the reaction temperature 90°C, pressure 4.5MPa, residence time 20min, and then, the synthetic reaction liquid was subjected to hydantoin hydrolysis reaction in the secondary microchannel reactor, reaction temperature 135°C, pressure 4.5MPa, residence time 50min. The hydrolysis reaction solution is stripped, evaporated and concentrated, crystallized, separated, decolorized, and dried to obtain glycine product with a content of 99.5% and a yield of 98.2%.

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Abstract

The invention provides a method for continuously preparing glycine from hydroxyacetonitrile by a microchannel reactor. The method comprises the following steps: preheating and mixing hydroxyacetonitrile, a carbon source and an ammonia source which serve as raw materials, sequentially performing hydantoin synthesis and hydantoin hydrolysis reaction in the microchannel reactor to obtain a glycine aqueous solution, and performing steam stripping, evaporation and concentration, crystallization, separation, decoloration and drying to obtain the glycine product. Compared with an existing method, themethod realizes continuous preparation of the glycine by taking the hydroxyacetonitrile as the raw material, and has the advantages of short reaction time, few byproducts, high glycine yield and lowpreparation cost.

Description

technical field [0001] The invention relates to the field of fine chemicals, in particular to a method for continuously preparing glycine from hydroxyacetonitrile using a microchannel reactor. Background technique [0002] Glycine, also known as aminoacetic acid, English Glycine, chemical formula C 2 h 5 NO 2 , with a molecular weight of 75.07, is the amino acid with the simplest structure. As an important fine chemical intermediate, it is widely used in the fields of pesticide, medicine, food, feed, daily chemical and organic synthesis. my country is the largest producer and consumer of glycine in the world, and the market size of glycine exceeds 350,000 tons. However, several glycine production methods in the prior art still have some disadvantages. E.g: [0003] (1) Hydrolysis method: Glycine is obtained by hydrolyzing, separating, refining, filtering, and drying natural proteins such as gelatin or silk as raw materials. This method consumes a lot of protein raw mat...

Claims

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Application Information

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IPC IPC(8): C07C227/24C07C229/08C07D233/74B01J19/00
CPCC07C227/24C07D233/74B01J19/0093
Inventor 杨仁俊龚文照张伟赫瑞元赵广李鑫韩萌毋楠袁秋华李伟斌
Owner 山西华阳集团新能股份有限公司
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