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A calcium phosphate reagent set for 3D printing and its preparation method and application

A 3D printing, calcium phosphate technology, applied in the direction of prosthesis, tissue regeneration, additive processing, etc., can solve the problems that affect the durability of bonding and filling materials, the porcelain blocks cannot be recycled, and the prosthesis breaks, etc., to achieve Conducive to long-term storage, good biocompatibility, and the effect of reducing dosage

Active Publication Date: 2020-10-30
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, CAD / CAM, which is used for 3D printing, has been widely used in the dental field since the 1980s. The commercialized dental CAD / CAM system has played a huge role in the production of all-ceramic restorations. The main working principle is the preformed raw material. Cutting, but the remaining porcelain blocks can only be discarded because they cannot be recycled; secondly, most of the dental materials such as zirconia and resin blocks are used, which are quite different from the mechanical properties such as elastic modulus of the tooth body, which is easy to cause Complications such as prosthetic fracture and tooth fracture
At present, the restoration materials used for tooth defects are mainly silver amalgam, composite resin, glass ionomer, etc. The materials used for root canal filling include gutta-percha tip and root filling paste. agent retention or mechanical retention, the aging of the bonding interface or material degradation will affect the durability of bonding and filling materials

Method used

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  • A calcium phosphate reagent set for 3D printing and its preparation method and application
  • A calcium phosphate reagent set for 3D printing and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment example 1

[0046] Take calcium chloride, methyl cellulose, polyaspartic acid, polyacrylic acid, water, and the composition of its parts by weight is 1000 parts of calcium chloride, 50 parts of methyl cellulose, 50 parts of polyaspartic acid, poly 50 parts of acrylic acid and 2000 parts of water. The preparation method is as follows: first dissolve calcium chloride and polyaspartic acid in deionized water, then add methyl cellulose and polyacrylic acid, and stir to synthesize gel A.

[0047] Dipotassium hydrogen phosphate, methyl cellulose, and water are weighed, and the components in parts by weight are: 600 parts of dipotassium hydrogen phosphate, 50 parts of methyl cellulose, and 1000 parts of water. The preparation method is as follows: first dissolving dipotassium hydrogen phosphate in deionized water, then adding methyl cellulose, and stirring to dissolve the synthetic gel B.

[0048] Mix Gel A and Gel B before printing, stir well, according to the information obtained by 3D scannin...

Embodiment example 2

[0051] Reduce the polyelectrolyte total weight composition in the implementation case 1 to be 10 parts, increase the calcium chloride weight composition to be 1500 parts, improve potassium dihydrogen phosphate weight composition to be 900 parts, all the other conditions remain unchanged, and the phase change time can be shortened to 3 hours . Increasing the amount of polyelectrolyte, reducing the amount of calcium salt and phosphate, can increase the phase transition time, and vice versa, speed up the phase transition.

Embodiment example 3

[0053] The weight part of polyacrylic acid in Example 1 is increased to 100 parts, and the other conditions remain unchanged, so that the curing time can be shortened to 6 hours. Increasing the amount of curing agent can speed up the curing time of the gel.

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Abstract

The invention relates to the technical field of preparation of medical biomaterials, in particular to a calcium phosphate reagent set for 3D printing as well as a preparation method and application ofthe calcium phosphate reagent set. The calcium phosphate reagent set for 3D printing contains gel A and gel B, wherein the gel A comprises polyelectrolyte, calcium salt, gel, a curing agent and water; and the gel B comprises phosphate, gel, a foaming agent and water. The preparation method comprises the steps as follows: adding the gel and the curing agent to an aqueous solution of polyelectrolyte and calcium salt to prepare the gel A containing the polyelectrolyte and calcium ions; and dissolving the gel and the foaming agent in an aqueous solution of phosphate to prepare the gel B containing phosphate ions. The gel A and the gel B are fully stirred and mixed before use to prepare mineralized water gel containing calcium phosphate. The mineralized water gel containing calcium phosphate can adjust curing time according to added polyelectrolyte and curing agent, can be pressurized and heated and can be applied to a calcium phosphate material for 3D printing.

Description

technical field [0001] The invention relates to the technical field of preparation of medical biological materials, in particular to a calcium phosphate reagent set for 3D printing and its preparation method and application. Background technique [0002] The main inorganic component of bone tissue is apatite, and hydroxyapatite is undoubtedly the best choice for bone substitute materials. However, due to its poor fluidity and small particles, its practical application is limited. Calcium phosphate bone cement, as a new type of self-fixing bioactive bone cement, has become an ideal bone graft material due to its good plasticity, degradability and biocompatibility. The existing bone cement is prepared by mixing the synthesized calcium phosphate with the gel component, so the time for the monocalcium phosphate, dicalcium phosphate, and tetracalcium phosphate in the bone cement to transform into hydroxyapatite cannot be controlled. With the development of 3D printing technolog...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/16A61L27/18A61L27/20A61L27/50B33Y70/10
CPCA61L27/12A61L27/16A61L27/18A61L27/20A61L27/50A61L2430/02A61L2430/12B33Y70/00C08L1/28C08L33/02C08L77/04
Inventor 傅柏平周子淮王喆施莹郑海燕
Owner ZHEJIANG UNIV
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