Preparation method and application of intelligent antibacterial hydrogel

A hydrogel, intelligent technology, applied in the field of biosensing, can solve problems such as the imbalance of drug-resistant microbial flora, and achieve good biocompatibility
CN110743035AInactive Publication Date: 2020-02-04GUANGXI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGXI UNIV
Publication Date
2020-02-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method and application of an intelligent antibacterial hydrogel. The method is realized through using vesicles loaded with self-extinguishment fluorescent dyes. The vesicles are sensitive to critical population density adjusting cell virulence factors produced by thalli; and under the circumstance that a wound is infected with bacteria, the produced thallus toxin can cause the breakage of the vesicles, so that the dyes are released from the vesicles, and intense fluorescence is emitted. Therefore, whether the wound is infected or not can be judged according to the fluorescence intensity, and the risk of being infected is further reduced. In addition, the synchronous intelligent response on pathogenic bacterium detection and sterilization can be realized through loading photosensitive antibacterial agents in the vesicles. Compared with a traditional pathogenic bacterium detection method, the preparation method of the intelligent antibacterial hydrogel has the characteristics of simple preparation process, convenience in operation, high efficiency, quickness, accuracy and the like.
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Description

technical field

[0001] The invention belongs to the technical field of biosensing, in particular to a preparation method and application of an intelligent antibacterial hydrogel. Background technique

[0002] With the widespread application of antibiotics in clinical practice, the problem of bacterial drug resistance is becoming more and more serious, and its drug resistance is increasing. pose great challenges. At present, the detection of pathogenic microorganisms and their drug resistance is mainly accomplished by analytical methods such as bacterial culture, biochemical identification, polymerase chain reaction amplification, real-time fluorescent quantitative gene amplification technology, enzyme-linked immunoassay and chip technology. The above-mentioned detection methods have problems such as long detection cycle, high cost, and cumbersome operation, which are difficult to meet the needs of clinical real-time detection. Therefore, the development of rapid and sensit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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