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The synthetic method of 4-chloro-3-(trifluoromethyl)benzene isocyanate

A technology of phenyl isocyanate and trifluoromethyl is applied in the field of synthesis of 4-chloro-3-phenyl isocyanate, which can solve the problems of difficult handling of iron sludge waste, easy generation of isomer impurities, hidden danger of hydrogen, etc., and reduce environmental protection The effect of stress, low risk, high cost

Active Publication Date: 2022-05-10
SHANDONG JINCHENG PHARMACCUTICAL CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main preparation route of 4-chloro-3-(trifluoromethyl)benzene isocyanate is to use ortho-chlorobenzotrifluoride as the starting raw material, through concentrated nitric acid / concentrated sulfuric acid mixed acid nitration to obtain nitrated compound, and then through iron powder / ethanol The system is reduced to an amide, and then reacted with triphosgene to obtain the target product. The nitrification process of this process requires high temperature, which is risky and easy to produce isomer impurities; the use of iron powder as an electron donor in the reduction process will produce iron sludge and waste residues that are difficult to handle. Environmental protection issues, and hydrogen will be produced during the reaction process, which will bring safety hazards

Method used

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  • The synthetic method of 4-chloro-3-(trifluoromethyl)benzene isocyanate
  • The synthetic method of 4-chloro-3-(trifluoromethyl)benzene isocyanate
  • The synthetic method of 4-chloro-3-(trifluoromethyl)benzene isocyanate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) In a 500ml three-necked flask, add 100g of o-chlorobenzotrifluoride and 200g of acetic anhydride and mix well, control the temperature at 10-12°C, add 65g of concentrated nitric acid dropwise, keep stirring for 3 hours after dropping, add 5% sodium hydroxide aqueous solution Adjust the pH to 8.0, separate the layers after washing, and collect 120.7 g of the organic phase;

[0046] (2) the organic phase obtained in step (1), 1g activated carbon, 7.5gFeCl 3 ·6H 2 O was added to 200 g of ethanol, mixed uniformly and then heated to reflux, and 86.5 g of hydrazine hydrate solution with a mass fraction of 80% was added dropwise, and the addition was completed within 3 hours. After the dropwise addition was completed, filter while hot, distill the filtrate to remove ethanol under normal pressure, add 1,2-dichloroethane for extraction and layering, and collect the organic phase;

[0047] (3) Add 65.7g of triphosgene and 1g of DMAP into 1,2-dichloroethane, stir until disso...

Embodiment 2

[0053] (1) In a 500ml three-neck flask, add 100g of o-chlorobenzotrifluoride and 220g of acetic anhydride and mix well, add 68g of concentrated nitric acid dropwise at a controlled temperature of 10-12°C, keep stirring for 3.5h after dropping, add 5% sodium hydroxide The pH of the aqueous solution was adjusted to 7.8, the layers were separated after washing, and 123.1 g of the organic phase was collected;

[0054] (2) the organic phase obtained in step (1), 1g activated carbon, 9.6gFeCl 3 ·6H 2 O was added to 200 g of ethanol, mixed uniformly and then heated to reflux, and 88.2 g of hydrazine hydrate solution with a mass fraction of 80% was added dropwise, and the addition was completed within 3 hours. After the dropwise addition is completed, filter while it is hot, evaporate the ethanol from the filtrate under normal pressure, add dioxane for extraction and layering, and collect the organic phase;

[0055] (3) Add 65.7g of triphosgene and 1g of pyridine into dioxane, stir ...

Embodiment 3

[0058] (1) In a 500ml three-necked flask, add 100g of o-chlorobenzotrifluoride and 210g of acetic anhydride and mix well, add 69g of concentrated nitric acid dropwise at a controlled temperature of 12-14°C, keep stirring for 4 hours after dropping, add 5% sodium hydroxide aqueous solution Adjust the pH to 7.5, separate the layers after washing, and collect 119.7 g of the organic phase;

[0059] (2) the organic phase obtained in step (1), 1g activated carbon, 8.4gFeCl 3 ·6H 2 O was added to 200 g of ethanol, mixed uniformly and then heated to reflux, and 83.9 g of hydrazine hydrate solution with a mass fraction of 80% was added dropwise, and the addition was completed within 3.5 hours. After the dropwise addition was completed, filter while it was hot, evaporate the ethanol from the filtrate under normal pressure, add chloroform for extraction and layering, and collect the organic phase;

[0060] (3) Add 65.7g of triphosgene and 1g of DMF into chloroform, stir until dissolved...

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to a synthetic method of 4-chloro-3-(trifluoromethyl)phenylisocyanate. The reaction of o-chlorobenzotrifluoride, acetic anhydride and concentrated nitric acid gives 4-nitro-2-trifluoromethyl chlorobenzene, 4-nitro-2-trifluoromethyl chlorobenzene, activated carbon, FeCl 3 ·6H 2 O reacts with hydrazine hydrate to obtain 4-chloro-3-trifluoromethylaniline, and 4-chloro-3-trifluoromethylaniline, triphosgene and catalyst react to obtain 4-chloro-3-(trifluoromethyl) benzene isocyanate . The nitration process of the present invention uses the acetic anhydride / concentrated nitric acid system to replace the traditional nitric acid / sulfuric acid mixed acid system, and the strong nitration effect of acetyl nitrate can complete the reaction at a lower temperature, with low risk and less nitration impurities; the reduction process uses FeCl 3 ·6H 2 The O / activated carbon / hydrazine hydrate system replaces the traditional iron powder reduction process, which avoids the generation of a large amount of iron sludge and waste, and reduces the pressure on environmental protection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a synthesis method of 4-chloro-3-(trifluoromethyl)phenylisocyanate. Background technique [0002] 4-Chloro-3-(trifluoromethyl)phenylisocyanate is an important pharmaceutical intermediate, mainly used in the synthesis of anticancer drug Sorafenib. Sorafenib is the first oral multi-kinase inhibitor that targets serine / threonine kinases and receptor tyrosine kinases on tumor cells and tumor blood vessels. These two kinases affect tumor cell proliferation and Angiogenesis, two activities that are critical in tumor growth. These kinases include RAF kinase, VEGFR-2 (vascular endothelial growth factor receptor), VEGFR-3, PDGFR-β (platelet-derived growth factor receptor), KIT, and FLT-3 (of the type III tyrosine kinase receptor family ). Sorafenib is a multi-target bio-targeted new drug jointly developed by Bayer and ONYX. The U.S. FDA approved Sorafenib for the treatment...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C263/10C07C265/12C07C209/36C07C211/52C07C201/08C07C205/12
CPCC07C263/10C07C209/365C07C201/08C07C265/12C07C211/52C07C205/12
Inventor 蔡会敏赵奇韩强李珊珊赵文勇
Owner SHANDONG JINCHENG PHARMACCUTICAL CHEM CO LTD
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