Preparation and application of mesenchymal stem cell secretion factors

A technology of mesenchymal stem cells and secreting factors, which is applied in the application of promoting angiogenesis and skin anti-aging and repairing, and the preparation of mesenchymal stem cells secreting factors, achieving the effects of high safety, high content, and strong ability to promote skin defect repair.
CN110898078AActive Publication Date: 2020-03-24SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
Publication Date
2020-03-24

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Abstract

The invention provides a preparation method of mesenchymal stem cell secretion factors. Compared with mesenchymal stem cells from other sources, such as umbilical cord mesenchymal stem cells, the mesenchymal stem cells from pluripotent induced stem cells used in the invention are more stable in source and not easy to age after in vitro passage. The preparation method is simple in preparation process, the component of the obtained mesenchymal stem cells secrete factors is a human-derived stem cell secretion factor; the potential tumorigenic hidden danger of the stem cells is avoided; no exogenous additive or preservative is contained; no mycoplasma or endotoxin is contained; irritability is not easily caused; storage is convenient; better angiogenesis promoting capacity and skin defect healing promoting capacity are achieved; obvious promoting effect on vascular cell proliferation and angiogenesis is achieved; skin repair can be promoted, and skin aging can be delayed through external application; and a promising application prospect in skin injury treatment and development of beauty and skin care products is achieved. .
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Description

technical field

[0001] The invention belongs to the field of medical care and health, and specifically relates to the preparation of a mesenchymal stem cell secreted factor derived from pluripotent induced stem cells and its application in the direction of promoting angiogenesis and skin anti-aging repair. Background technique

[0002] Aging is an inevitable stage in the development of body life activities, and skin aging is the most external feature of body aging. Studies have shown that skin aging is a complex physiological process, which is the result of multiple mechanisms. In addition to the reduction of collagen fiber synthesis and elastic fiber degeneration in a broad sense, vascular aging is also considered to be one of the important signs of skin aging. Slowing down vascular aging and promoting angiogenesis will be a new direction for skin rejuvenation treatment.

[0003] Mesenchymal stem cells (MSC) have the characteristics of strong tissue repair ability, strong ...

Claims

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