Monoethyl fumarate calcium salt for eradicating gastrointestinal disease helicobacter pylori infection and application thereof

A technology of monoethyl fumarate calcium salt and monoethyl fumarate, which can be applied to medical preparations with no active ingredients, medical preparations containing active ingredients, antibacterial drugs, etc., and can solve the problem of no breakthrough progress , Difficulty in eradication, reduction in eradication rate, etc., to achieve the effects of high recovery rate of ulceration, reduction of pepsin excretion, and relief of disease symptoms

Inactive Publication Date: 2020-03-24
GANZHOU ANHONG ENVIRONMENTAL PROTECTION TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as the rate of Hp resistance to antibiotics increases, the eradication rate is gradually decreasing. After the emergence of drug resistance, eradication will be more difficult, and there is still no breakthrough in research

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0055] The preparation steps of monoethyl fumarate are:

[0056] In a 1000mL three-neck flask, add 200g of maleic anhydride and 145mL of absolute ethanol, start stirring, heat in a water bath to 60°C, react for 3 hours, cool to room temperature, add 2g of anhydrous aluminum chloride to the reaction flask, and heat up To 90°C, react for 2 hours, add 160mL of toluene, filter while hot, stir and cool the filtrate, there are a lot of white solids, filter to obtain monoethyl fumarate.

preparation example 2

[0058] The preparation steps of monoethyl fumarate calcium salt are:

[0059] Get monoethyl fumarate 500g, add in the reaction bottle, add 1.5 Kg pure water, add 153g calcium carbonate slowly under stirring, stir reaction 7 hours. Filter the reaction solution to remove impurities, distill off water at 70°C under reduced pressure, cool down to 5°C for crystallization for 3 hours, filter, collect crystals, and dry the obtained crystals at 60°C for 5 hours to obtain monoethyl fumarate Calcium salts.

preparation example 3

[0061] The preparation steps of Arrowhead mushroom extract are:

[0062] Take the Arrowhead mushroom, dry it, crush it, extract it with 7 times the weight of 93% (volume) ethanol at room temperature for 4 times, and then use 15 times the weight of 40% (volume) ethanol at room temperature for 1 time, each time for 48h, Filter, and extract the residue with 5 times the weight of 50% (volume) ethanol in a 50°C water bath for 4 times, 2 hours each time, combine the extracts, filter, concentrate under reduced pressure until there is no alcohol smell, and obtain the crude extract. The crude extract was diluted with an appropriate amount of distilled water to a relative density of 1.1 to 1.2 at room temperature, mixed evenly, extracted twice with equal volumes of chloroform and ethyl acetate, combined, and concentrated under reduced pressure to obtain the extract Shanci Mushroom Extract.

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PUM

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Abstract

The invention relates to monoethyl fumarate calcium salt for eradicating gastrointestinal disease helicobacter pylori infection and an application thereof. The monoethyl fumarate calcium salt is a medicine for eradicating gastrointestinal disease helicobacter pylori infection and is prepared from monoethyl fumarate calcium salt, an edible tulip extract, chitosan, starch and magnesium stearate. Compared with the existing medicament for treating intestines and stomachs, the monoethyl fumarate calcium salt provided by the invention has the advantages of the cure rate of ulceration is high; gastric acid secretion can be fundamentally treated; collapse formation is inhibited; the pepsase discharge amount is reduced; and the growth of helicobacter pylori is radically treated. The disease symptoms are relieved in a short time. The medicament has an obvious radical treatment effect on chronic atrophic gastritis. HP negative conversion is promoted for patients accompanied by HP infection. The HP negative conversion rate reaches 99.6 percent, and the curative effect is remarkable.

Description

technical field [0001] The invention relates to a new application of a monoethyl fumarate composition, in particular to a monoethyl fumarate calcium salt for eradicating gastrointestinal Helicobacter pylori infection and its application. Specifically, monoethyl fumarate calcium salt is used to eradicate gastric or duodenal Helicobacter pylori infection. Background technique [0002] Epidemiological studies have shown that the infection rate of Helicobacter pylori is as high as 50% worldwide, about 80% in developing countries, and 40% in developed countries. The infection rate in my country is 30% to 60%, and the infection age is earlier than In developed countries, the infection rate is 41.98% in 20-29 years old, and 78.9% in 70 years old and above. Helicobacter pylori is an important pathogenic factor of chronic gastritis, peptic ulcer, gastric cancer and other gastrointestinal diseases. Clinical surveys on patients with chronic stomach disease found that most patients hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K31/225A61K9/08A61K9/14A61K9/20A61K9/48A61K47/36A61P1/04A61P31/04
CPCA61K9/0095A61K9/146A61K9/2059A61K9/4866A61K31/225A61K36/898A61K47/36A61K2236/333A61K2236/39A61K2236/51A61P1/04A61P31/04A61K2300/00
Inventor 刘威衢刘威鑫胡剑
Owner GANZHOU ANHONG ENVIRONMENTAL PROTECTION TECH CO LTD
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