Artificial intravascular stent and preparation method and application thereof

An artificial blood vessel and cavity technology, applied in the field of artificial blood vessel stent and its preparation, can solve the problems of low survival rate of endothelial cells, and achieve the effects of improving the survival rate, excellent patency, and increasing ATP content

Inactive Publication Date: 2020-03-27
段传志 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of the technical problems existing in the prior art, one of the purposes of the present invention is to provide an artificial vascular stent, which can not only solve the current problem of unobstructed small-diameter blood vessels, but also solve the problem of low survival rate of endothelial cells. question

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  • Artificial intravascular stent and preparation method and application thereof
  • Artificial intravascular stent and preparation method and application thereof
  • Artificial intravascular stent and preparation method and application thereof

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preparation example Construction

[0049] The preparation of solvates is generally known. Typical, non-limiting procedures include dissolving the compound in the required amount of the desired solvent (organic or water or mixtures thereof) at above ambient temperature, cooling the solution at a rate sufficient to form crystals, and then isolating the crystals by standard methods. Analytical techniques such as infrared spectroscopy can confirm the presence of solvent (or water) in crystals as solvates (or hydrates).

[0050] The term "prodrug" as used herein means a substance that is transformed in vivo into a compound having formula (A) or the structure of formula (A) or a pharmaceutically acceptable salt of the compound. Transformation can be accomplished by various mechanisms (eg, by metabolic or chemical processing), eg, by hydrolysis in blood.

[0051] The compounds described herein can be administered alone or in combination with other pharmaceutically acceptable compounds.

[0052] As used herein isomer...

no. 1 approach

[0059] The first embodiment of the present invention provides an artificial vascular stent, the artificial vascular stent is a cylindrical body with a cavity formed by the cavity wall, and the cavity wall includes an interlaced structure formed by overlapping fiber filaments ;

[0060] The average diameter of a single fiber filament is 0.5-1 μm;

[0061] The fiber filaments are derived from polymer materials, and AMPK agonists are mixed in the polymer materials.

[0062] Such as figure 1 and Figure 9 As shown, the AMPK agonist of the present invention can be loaded onto the artificial vascular stent of the present invention, and can be well fused with polymer materials. The artificial blood vessel stent of the present invention can increase the content of adenosine triphosphate (ATP) in the endothelial cells after inflammation, protect the endothelial cells from inflammatory damage, improve the survival rate of the endothelial cells, and have excellent patency.

[0063] ...

no. 2 approach

[0078] The second embodiment of the present invention provides a method for preparing the artificial vascular stent according to the first embodiment of the present invention, which includes preparing a spinning solution containing an AMPK agonist, which is prepared by electrospinning, wherein,

[0079] The artificial vascular stent is a cylindrical body with a cavity formed by the cavity wall, and the cavity wall includes an interlaced structure formed by overlapping fiber filaments;

[0080] The average diameter of a single fiber filament is 0.5-1 μm;

[0081] The filaments are derived from a polymer material mixed with an AMPK agonist.

[0082] The spinning solution containing the AMPK agonist can be prepared by dissolving it in the first solvent to obtain the AMPK agonist solution, and then mixing it with the pretreatment solution.

[0083] Specifically, in the spinning solution containing the AMPK agonist, the mass concentration of the polymer material is 0.5-4 g / mL; and...

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Abstract

The invention provides an artificial intravascular stent and a preparation method and application thereof. The artificial intravascular stent is a cylindrical body with a cavity formed by a cavity wall, and the cavity wall comprises a staggered structure formed by mutual lap joint of cellosilk; the average diameter of a single cellosilk is 0.5-1 micron; and the cellosilk is derived from a high polymer material, and an AMPK agonist is mixed in the high polymer material. According to the artificial intravascular stent, the ATP content of inflammatory endothelial cells can be increased, the endothelial cells are protected from inflammation damage, the survival rate of the endothelial cells is increased, and smoothness is excellent. Furthermore, the artificial intravascular stent can be degraded with proper degradation speed, and is suitable for preparing vascular repair products.

Description

technical field [0001] The invention relates to an artificial blood vessel stent and its preparation method and application, belonging to the field of medical implant materials. Background technique [0002] Cardiovascular disease is the cause of the highest mortality rate in the world. Relevant literature predicts that by 2030, the annual death toll related to cardiovascular disease will reach 23.3 million. The treatment of cardiovascular diseases includes diet adjustment, lifestyle changes, drug intervention and surgery. Vascular bypass grafting is considered to be the best choice for patients who need long-term maintenance of revascularization. Among them, autologous blood vessels (such as saphenous vein, radial Arteries and internal thoracic arteries) are the most ideal donors for vascular grafting. However, due to the lack of sources of autologous blood vessels and trauma damage to the cut site, the wide application of autologous vascular grafts is greatly limited. Syn...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/54A61L27/18A61L27/22A61F2/82
CPCA61L27/50A61L27/54A61L27/18A61L27/222A61F2/82A61L2400/12A61L2300/216A61L2300/41A61F2240/001
Inventor 苏亨贤段传志刘文超黄庆郭慎全龙小燕
Owner 段传志
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