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Method for preparing coix seed oil composite nanoparticles

A technology of Coix seed oil and composite granules, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and drug combinations, etc. Long time and other problems, to achieve the effect of improving digestion resistance and targeted absorption, low production cost, and reducing preparation time

Active Publication Date: 2020-06-05
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the problems of high production cost, long preparation time, poor taste experience, weak resistance to digestion and targeted absorption in the existing production methods of coix seed oil nanoparticles, the primary purpose of the present invention is to provide a coix seed oil nanoparticle Preparation method of composite particles to reduce the raw material cost of coix seed oil oral nanoparticles and achieve better targeted absorption in vivo

Method used

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  • Method for preparing coix seed oil composite nanoparticles
  • Method for preparing coix seed oil composite nanoparticles
  • Method for preparing coix seed oil composite nanoparticles

Examples

Experimental program
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Effect test

Embodiment 1

[0032] A high-efficiency preparation method of coix seed oil nanocomposite particle carrier, comprising the following steps:

[0033] (1) Dispersing wheat gliadin (Gliadin) in 60% (V / V) ethanol solution, until the mass fraction of gliadin in the solution is 1%, until it is completely dissolved;

[0034] (2) Coix seed oil (CSO) was added at a mass ratio of 5:1 to prolamin, and magnetically stirred until the coix seed oil was completely dispersed and dissolved to obtain a dispersion;

[0035] (3) Pour the carboxymethyl chitosan (CMCS) solution into the vortex-stirred dispersion until the mass fraction of carboxymethyl chitosan in the dispersion is 0.5%, adjust the pH value to 4, stir for 10 min, and rotate Evaporate for 10min to remove ethanol;

[0036] (4) Add calcium ion solution until the mass fraction of calcium ion in the reaction system is 0.5%, stir for 10min,

[0037] Coix seed oil-prolamin-carboxymethyl chitosan-calcium ion colloid solution was prepared.

[0038] (5)...

Embodiment 2-5

[0040] Polysaccharide is carboxymethyl chitosan, and add-on is respectively 1mg (accounting for dispersion liquid mass fraction 0.1%) (embodiment 2), 2mg (accounting for dispersion liquid mass fraction 0.2%) (embodiment 3), 3mg (accounting for dispersion liquid mass fraction 0.2%) (embodiment 3), 3mg (accounting for dispersion liquid mass fraction 0.3% by mass fraction) (Example 4), 4 mg (accounting for 0.4% by mass fraction of the dispersion liquid) (Example 5), calcium ions accounted for 0.5% by mass fraction of the reaction system.

[0041] Other steps and raw materials are with embodiment 1.

[0042] The particle diameter (Size), surface potential (Zeta) and embedding efficiency (EE) of above embodiment gained nanoparticle are as follows figure 1 shown. It can be seen that the coix seed oil-prolamin-carboxymethyl chitosan nanoparticles obtained in each embodiment maintain good particle size and potential, and the embedding rate is >50%. When the mass fraction of carboxym...

Embodiment 6-11

[0044] Calcium ion is as cation, and its consumption is respectively 0mg (embodiment 6), 0.05mg (accounting for reaction system mass fraction is 0.05%) (embodiment 7), 0.1mg (accounting for reaction system mass fraction is 0.1%) (embodiment 8 ), 0.2mg (accounting for reaction system mass fraction is 0.2%) (embodiment 9), 0.3mg (accounting for reaction system mass fraction is 0.3%) (embodiment 10), 0.4mg (accounting for reaction system mass fraction is 0.4%) (Example 11). The mass fraction of carboxymethyl chitosan in the dispersion is 0.2%.

[0045] Other steps and raw materials are with embodiment 1.

[0046] The particle diameter (Size), surface potential (Zeta) and embedding efficiency (EE) of above embodiment gained nanoparticle are as follows figure 2 shown. It can be seen that the coix seed oil-prolamin-carboxymethyl chitosan nanoparticles obtained in each embodiment maintain good particle size and potential, and the embedding rate is >50%. When the mass fraction of...

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Abstract

The invention discloses a method for preparing coix seed oil composite particles. The method comprises the following steps: dissolving an alcohol-soluble protein in an ethanol solution, adding coix seed oil so as to prepare a dispersion solution, then, adding a polysaccharide solution until the mass percent of polysaccharides in the dispersion solution is 0.1%-0.5%, adjusting a pH value to 2-7, carrying out rotary evaporation to remove ethanol, then, adding a cationic solution until the mass percent of cations in a reaction system is 0.05%-0.50%, and carrying out spray drying, thereby obtaining the coix seed oil composite nanoparticles. According to the method disclosed by the invention, wall material loss of the nanoparticles is lowered, particle sizes of the nanoparticles can be furtherreduced through a static crosslinked action of the cations and the polysaccharides, and a protective layer of a coix seed oil-alcohol-soluble protein is formed; and in a process that the coix seed oil-alcohol-soluble protein enters an intestinal tract of a human body, wall material loss of the alcohol-soluble protein is reduced, and the coix seed oil can reach the intestinal tract in good condition.

Description

technical field [0001] The invention relates to a method for preparing coix seed oil nanocomposite particles. Background technique [0002] Coix seed oil accounts for 2 to 7% of Coix seed, mainly containing coixenyl, coix lactone and sterol compounds, and unsaturated fatty acids are mainly oleic acid and linoleic acid, accounting for 85% of triglycerides. Coix seed oil has a good curative effect on anti-cancer and improving the body's immunity. It has been reported that routine oral administration of coix seed oil is safe, without skin irritation and rectal irritation, but its taste is poor, greasy, and poor absorption. The long-term clinical use of coix seed oil injection fat emulsion can reduce platelet Ⅲ / Level IV. [0003] Chinese patent application CN 104147436A discloses a coix seed oil oral nanoparticle and its preparation method. The composition of the method is as follows: 1 weight part of coix seed oil, 20 weight parts of polylactose glycolic acid polymer, 40 wei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/51A61K47/42A61K47/36A61P35/00A61P37/04
CPCA61K36/8994A61K9/5169A61K9/5161A61P35/00A61P37/04
Inventor 廖兰杨彦红郑文宇林维杰文晓燕周苏斌
Owner FOSHAN UNIVERSITY
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