Bispecific PSMA/GRPr targeted bimodal imaging nano contrast agent as well as preparation method and application thereof

A nano-contrast agent, bispecific technology, applied in the field of biomedicine, can solve problems such as poor effect of prostate cancer, and achieve the effect of enhancing active targeting effect, increasing hydrophilicity, and enhancing photothermal effect
CN111558052AActive Publication Date: 2020-08-21RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Publication Date
2020-08-21

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Abstract

The invention belongs to the field of contrast agents, and provides a bispecific PSMA / GRPr targeting bimodal imaging nano contrast agent, PLGA-PEG is used as a shell membrane, liquid fluorocarbon 1H-perfluoropentane and Fe3O4 nanoparticles are wrapped in the PLGA-PEG, and a heterodimer polypeptide is connected to the shell of the PLGA-PEG. The invention also provides an application of the contrastagent in preparing a medicine for diagnosing or treating prostatic cancer. The invention also provides a preparation method of the contrast agent. The average particle size of the prepared nano contrast agent is 213.7 + / -65.27 nm; Fe3O4 nanoparticles play a role in magnetic resonance imaging, 1H-perfluoropentane has the characteristics of liquid-gas phase change and has the advantages of stability and low energy required by phase change, the effects of ultrasonic and photoacoustic imaging, drug controlled release and the like are played, and the designed polypeptide can efficiently and specifically target prostate cancer cells. The nano contrast agent provided by the invention can simultaneously target two important target points PSMA and GRPr of prostate cancer.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to a contrast agent, in particular to a bispecific PSMA / GRPr targeted dual-mode imaging nano-contrast agent and its preparation method and application. Background technique

[0002] Prostate cancer lesions are sporadic, multifocal, and difficult to be accurately detected by imaging techniques. At present, the value of imaging techniques in the diagnosis and staging of prostate cancer is still unsatisfactory, and its sensitivity and specificity still cannot rule out random puncture. Finding an imaging method that can accurately detect prostate cancer is a clinical problem that needs to be solved urgently. The rapid development of nanomedicine provides a new means to solve the above problems. The construction of targeted molecular probes can pass through the microvessels of prostate tumors, enter the interstitial space, specifically bind to prostate cancer cells, and have a good enhanced imag...

Claims

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