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11-O-mogrol oxime ether derivative serving as oral liquid antioxidant additive, and anti-oxidative and anti-aging oral liquid

A technology of Luo Han Guo and oral liquid, applied in the fields of antivirus, food science, organic chemistry, etc.

Active Publication Date: 2020-08-21
HUNAN HUACHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no oral liquid product using 11-O-mogrosvenol derivatives as an antioxidant

Method used

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  • 11-O-mogrol oxime ether derivative serving as oral liquid antioxidant additive, and anti-oxidative and anti-aging oral liquid
  • 11-O-mogrol oxime ether derivative serving as oral liquid antioxidant additive, and anti-oxidative and anti-aging oral liquid
  • 11-O-mogrol oxime ether derivative serving as oral liquid antioxidant additive, and anti-oxidative and anti-aging oral liquid

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] Preparation Example 1 The preparation of formula (I) compound

[0038](1) Oximation and post-treatment: Take 23.8g of 11-O-mogrogol, dissolve it in 150ml of anhydrous methanol, add 4.5g of hydroxylamine sulfate (containing 0.055mol of hydroxylamine) and 20.2g of triethylamine, and react under reflux at 70°C for 5 hours , after the completion of the silica gel TLC test reaction, concentrated under reduced pressure until the solid content of the concentrated solution was 25%, cooled the concentrated solution to a temperature of 10°C, stirred at a speed of 10r / min, crystallized for 18 hours, suction filtered, and dried to obtain 11- Oxime-Mogrosanol 21.6g.

[0039] (2) Etherification and post-treatment: Dissolve 20.2 g (0.04 mol) of 11-oxime-mogrosanol obtained in step (1) in 110 ml of DMF, add 3.14 g of allyl chloride and 0.08 g of sodium tert-butoxide, and react at 5°C for 5 hours. Silica gel TLC test After the reaction is over, pour the reaction solution into 1000ml o...

preparation example 2

[0041] Preparation example 2 Preparation of Monk Fruit Decolorized Concentrated Juice

[0042] (1) Juicing and cold extraction of fresh fruit: After washing 200kg of Luo Han Guo fresh fruit, squeeze it with a juicer, and extract the pomace with 600kg of ice water at 8°C twice for 0.5 hours each time. The water extracts are combined to obtain Luo Han Guo juice;

[0043] (2) Enzymolysis, boiling, and centrifugation: adjust the pH value of the Luo Han Guo fruit juice obtained in step (1) to 9 with a saturated aqueous solution of calcium hydroxide, then add 0.1 kg of alkaline protease preparation, and perform enzymatic hydrolysis for 1.5 hours at 25°C , and then, heat and boil the enzymolysis liquid at 90°C for 0.5h, rapidly cool it to 30°C at a speed of 2°C / min, and centrifuge to obtain the enzymolysis centrifugation liquid;

[0044] (3) desalination, dealkalization: with step (2) gained enzymolysis centrifugal liquid, the flow rate of above post is 1.5BV / h, goes up 001 * 7 ty...

preparation example 3

[0047] Preparation example 3 Okra Sauce Preparation

[0048] a. Extraction: 50 kg of fresh okra was washed with water, crushed with a beater, added 300 kg of pure water, heated to 85° C., stirred and extracted for 2 hours, filtered to obtain okra extract;

[0049] b. Purification: Cool the okra extract to room temperature, add complex enzymes (0.06 kg each of pectinase, protease and cellulase), enzymolyze at 35°C for 4 hours, and inactivate the enzyme at 90°C. Add 0.1 kg of activated carbon, stir for 1 hour to decolorize, filter with a ceramic membrane, and concentrate the ceramic membrane filtrate under reduced pressure at 70°C and -0.08MPa to a sugar content of 40brix to obtain 9.6 kg of okra juice.

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Abstract

The invention provides an 11-O-mogrol oxime ether derivative represented by formula (I) and serving as an oral liquid antioxidant additive, and an anti-oxidative and anti-aging oral liquid taking thecompound of the formula (I) as an antioxidant. The oral liquid is prepared from, by weight, 0.2 to 0.5 part of the 11-O-mogrol oxime ether derivative of the formula (I), 20 to 30 parts of fructus momordicae decolorized concentrated juice, 3 to 6 parts of okra juice and 100 to 150 parts of water. The oral liquid provided by the invention is mellow and normal in taste, reserves the special flavor ofmomordica grosvenori, and is clear and transparent in color and rich in flavor and fruity flavor. Mouse tests prove that the oral liquid can significantly improve the anti-oxidation ability of mice.Therefore, the oral liquid provided by the invention can effectively relieve and prevent oxidative damage of free radicals in a biological organic body to organs.

Description

technical field [0001] The invention relates to the field of natural product transformation, in particular to a 11-O-mogroxime ether derivative as an antioxidant additive for oral liquid and an oral liquid Background technique [0002] Some studies believe that the aging of the human body is partly due to free radicals triggering lipid peroxidation, producing metabolites such as lipid peroxide (LPO), which form brown substances and deposit in various organs, eventually leading to physiological functions and damage of cells. Lead to decreased immunity, memory loss and so on. These free radicals include oxygen free radicals, hydrogen free radicals and hydrogen peroxide, etc., which widely exist in body tissues and attack unsaturated fatty acids in cell membranes and mitochondrial membranes, resulting in enhanced lipid peroxidation, and lipid peroxidation products can be Decomposed into more free radicals, causing a chain reaction of free radicals, causing extensive damage to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00A61K36/42A61P39/06A23L33/105A23L19/00A61K9/08A61K31/575
CPCA23V2002/00A61K9/0095A61K31/575A61K36/185A61K36/42A23L19/09A23L33/105A61P39/06C07J9/00A23V2200/302A23V2250/21A61K2300/00
Inventor 李伟黄华学
Owner HUNAN HUACHENG BIOTECH
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