PGS/SF electrospun artificial blood vessel and preparation method thereof

An artificial blood vessel and electrospinning technology, which can be used in blood vessels, electrospinning, and devices for human tubular structures. It can solve problems such as unknown performance, achieve controllable degradation rate, promote adhesion and proliferation, and achieve successful transplantation. Effect

Active Publication Date: 2020-09-29
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether the above-mentioned micro-nano-scale oriented fibers have good film-forming properties, and the performance after film formation is still unknown, and w

Method used

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  • PGS/SF electrospun artificial blood vessel and preparation method thereof
  • PGS/SF electrospun artificial blood vessel and preparation method thereof
  • PGS/SF electrospun artificial blood vessel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Synthesis of PGS prepolymer: Take 0.1mol of sebacic acid and 0.1mol of glycerin into a 250mL three-necked flask, place it on a magnetic stirrer to stir and heat the reaction, feed nitrogen at room temperature, heat in an oil bath, and stir at 125°C After heating for 4 hours, the monomers were completely melted and mixed uniformly. The reaction was continued for 48 h while maintaining the temperature under a nitrogen atmosphere to obtain a PGS prepolymer. Cooled to room temperature to white waxy solid, stored at 4-8°C for later use.

[0056] The synthetic route of PGS is as follows, wherein n=6-50:

[0057]

[0058] (2) Preparation of SF membrane: Weigh 21.2g of anhydrous sodium carbonate and dissolve it in 10L of deionized water that has been heated and boiled, then degumming 25g of silkworm silkworm silk at 100°C for 30min, and take it out with deionized water after degumming is complete Repeat washing five times to remove residual sericin. After the filament...

Embodiment 2

[0064] According to the method of embodiment 1 step (1)-(2), choose the concentration of spinning solution to be 9%, change the mass ratio of PGS and SF to be 70 / 30, 50 / 50, 30 / 70 to prepare artificial blood vessel, in step ( In 3), the receiving device was replaced by a stainless steel roller with a diameter of 4mm. In order to facilitate the removal of the sample from the stainless steel, the PEO aqueous solution with a mass ratio of 7.5% was pre-spun on the stainless steel roller, and the PEO spinning time was 3-5min. The electrospinning parameters were set as follows: voltage 12.5-15kV, receiving distance 12cm, flow rate 2mL / h, spinning time 1-1.5h, rotation speed 500r / min. The micro-nano-scale fibers produced during the electrospinning process are wound outside the receiving device to form a tubular PGS / SF electrospun membrane. After the spinning is complete, the receiving device with the tubular PGS / SF electrospun membrane is immersed in water to remove the PEO layer. PGS...

Embodiment 3

[0079] According to the method of Example 2, the pipes were prepared using the mass ratios of PGS and SF as 70 / 30, 50 / 50, and 30 / 70, except that they were cured at 120, 125, 130, 135, and 140° C. for 24 hours. Such as Figure 10 Shown are the tensile properties of various mass ratios of PGS / SF tubular materials under different curing conditions. When the temperature is lower than 130°C, the mechanical properties of PGS / SF tubular materials are poor, and the curing rate of PGS is not high; when the curing temperature is raised to 130°C, the mechanical properties of PGS / SF tubular materials are significantly improved, and with As the curing temperature increases again, the breaking strength and elongation at break increase accordingly.

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Abstract

The invention relates to a PGS/SF electrospun artificial blood vessel and a preparation method thereof. The invention discloses a preparation method of the PGS/SF electrospun artificial blood vessel.The method comprises the following steps: 1, dissolving a PGS prepolymer and SF into an organic solvent to obtain a spinning solution; carrying out electrostatic spinning on the spinning solution; receiving micro-nano fibers by adopting a cylindrical receiving device rotating around the axis of the receiving device, winding the micro-nano fibers outside the receiving device to form a tubular PGS/SF electrospun membrane; and drying and solidifying the tubular PGS/SF electrospun membrane after completely spinning to obtain a PGS/SF electrospun artificial blood vessel. According to the PGS/SF electrospun artificial blood vessel, the spinnability and fiber forming property of PGS are improved through the SF, the PGS/SF electrospun artificial blood vessel is successfully obtained, the caliber of the electrospun artificial blood vessel is smaller than 6 mm, and the electrospun artificial blood vessel has the excellent elasticity of the PGS and the excellent biological and mechanical properties of the SF.

Description

technical field [0001] The invention relates to an electrospun membrane, in particular to a PGS / SF electrospun artificial blood vessel and a preparation method thereof. Background technique [0002] Vascular diseases are one of the main diseases that cause high mortality in humans. For patients with severe damage, surgical operations such as vascular graft replacement or bypass grafting are usually effective treatments. At present, large and medium-caliber artificial blood vessels (>6mm) have been used clinically, such as polyester (Dacron) and expanded polytetrafluoroethylene (ePTFE) artificial blood vessels prepared by weaving or braiding. Small-diameter artificial blood vessels (<6mm) are still in the research stage. Because of the mismatch between the compliance of the host blood vessel after transplantation and the formation of stress concentration areas at the anastomosis, problems such as thrombus, intimal hyperplasia at the anastomosis, and aneurysms occur. Th...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61F2/06D04H1/728D04H3/02D01D5/00
CPCA61L27/507A61F2/06D04H1/728D04H3/02D01D5/003D01D5/0076D10B2509/06
Inventor 赵荟菁孟凯张迎梅
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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