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pgs/sf electrospun artificial blood vessel and its preparation method

An artificial blood vessel and electrospinning technology, applied in the directions of blood vessels, electrospinning, and devices of human tubular structures, etc., can solve problems such as unknown performance, achieve good mechanical properties, achieve successful transplantation, and be easy to operate.

Active Publication Date: 2022-03-29
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether the above-mentioned micro-nano-scale oriented fibers have good film-forming properties, and the performance after film formation is still unknown, and when used in vivo, because the internal environment is a water environment, PEO will dissolve in water, resulting in the dissolution or degradation of the fibers

Method used

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  • pgs/sf electrospun artificial blood vessel and its preparation method
  • pgs/sf electrospun artificial blood vessel and its preparation method
  • pgs/sf electrospun artificial blood vessel and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Synthesis of the PGS prepolymer: Take 0.1 mol sebacate and 0.1 mol glycerol to 250 ml of three-necked flask, placed in a magnetic stirrer and stir well, and vent the nitrogen gas at room temperature, oil bath heating, 125 ° C stirring After the heating reaction is 4h, the monomer is completely melted and uniformly mixed. The temperature was maintained at a nitrogen atmosphere to continue to rely at 48 h to give a PGS prepolymer. Cooling to room temperature is white waxy solid, 4-8 ° C preserve spare.

[0056] The PGS synthesis route is shown below, where n = 6-50:

[0057]

[0058] (2) Preparation of the SF film: 21.2 g of anhydrous sodium anhydrous sodium carbonate is dissolved in 10L has heated boiling deionized water, and then the 25g silkworm is removed from 30 min under the boiling conditions of 100 ° C, and then removed from the elimination Repeatedly wash five times and remove the residual silk glue. The silk is dried in an oven at 60 ° C to dryness to obtain p...

Embodiment 2

[0064] According to the method of the first step (1) - (2), the spinning liquid concentration is 9%, the mass ratio of the PGS and SF is selected from 70 / 30, 50 / 50, 30 / 70, and the artificial blood vessel is prepared in the step. 3) In the middle, the receiving device replaces a stainless steel roller having a diameter of 4 mm, and is prepared from the stainless steel to the stainless steel, and the PEO solution is pre-textured on the stainless steel roller, and the PEO spinning time is 3-5 min. The electrospinning parameters are set as follows: 12.5-15 kV of the voltage, 12cm reception distance, 2 ml / h, spinning time 1-1.5H, and speed 500R / min. The micro-nano-stage fibers generated during electrostatic spinning process wrapped around the receiving device forming a tubular PGS / SF electrospun film. After the spinning is completely immersed in the water receiving device to remove the PEO layer, The PGS / SF electrospin pipe can be smoothly released.

[0065] Since PGS has adjus...

Embodiment 3

[0079] According to the method of Example 2, the tubing was prepared by the mass ratio of PGS and SF as 70 / 30, 50 / 50, 30 / 70, and the difference was that 24 h was cured at 120, 125, 130, 135, 140 ° C. Such as Figure 10 The tensile properties shown in each mass ratio PGS / SF tubular material under different curing conditions. When the temperature is less than 130 ° C, the mechanical properties of the PGS / SF tubular material are poor, and the CGS curing rate is not high; when the curing temperature is increased to 130 ° C, the mechanical properties of the PGS / SF tubular material have a significant increase, and The curing temperature is again improved, and the breakage intensity and elongation elongation increases.

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Abstract

The invention relates to a PGS / SF electrospun artificial blood vessel and a preparation method thereof. The preparation method of the PGS / SF electrospun artificial blood vessel of the present invention comprises the following steps: dissolving the PGS prepolymer and SF in an organic solvent to obtain a spinning solution, performing electrospinning on the spinning solution, and adopting a cylinder rotating around its own axis The shaped receiving device receives micro-nano-scale fibers, and the micro-nano-scale fibers are wound outside the receiving device to form a tubular PGS / SF electrospun membrane. After the spinning is complete, the tubular PGS / SF electrospun membrane is dried and solidified to obtain PGS / SF Electrospun artificial blood vessels. The invention uses SF to improve the spinnability and fibrosis of PGS, and successfully obtains PGS / SF electrospun artificial blood vessels. The caliber of the electrospun artificial blood vessels is less than 6mm, which has both the excellent elasticity of PGS and the excellent biology and mechanics of SF performance.

Description

Technical field [0001] The present invention relates to an electrospun film, and more particularly to a PGS / SF electrospun artificial blood vessel and a preparation method thereof. Background technique [0002] Vascular disease is one of the major diseases that cause high human mortality. For patients with severe impaired parts, surgery such as angiogenesis or bypass bridge is usually taken, which is an effective treatment. At present, the large medium-bearing artificial blood vessel (> 6 mm) has been used for clinical, such as polyester (DACRON) and expanded polytetrafluoroethylene (EPTFE), which is prepared by a woven or woven method. Small-diameter artificial blood vessels (<6mm) is still in the research stage, due to their transplantation, the compliance of the host blood vessels, resulting in the formation of stress concentration zones in the anastomosis, thrombosis, anastomic hyperplasia and aneurysm, etc. The main reason for the failure of transplantation. [0003]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61F2/06D04H1/728D04H3/02D01D5/00
CPCA61L27/507A61F2/06D04H1/728D04H3/02D01D5/003D01D5/0076D10B2509/06
Inventor 赵荟菁孟凯张迎梅
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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