Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of hydroxyapatite porous ceramic capable of being used as artificial bone

A technology of hydroxyapatite and porous ceramics, which is applied in the fields of bioengineering and material science, can solve problems such as reduction, clinical application limitations, and impact on material applications, and achieve the effects of simple process, easy large-scale production, and reliable performance

Inactive Publication Date: 2020-11-03
SINOSTEEL LUOYANG INST OF REFRACTORIES RES
View PDF7 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional ceramic materials such as tricalcium phosphate and hydroxyapatite have no pores inside or the pores are too small in diameter, resulting in the pore channels failing to meet the structural requirements of bone unit inward growth, affecting nutrient delivery and bone induction, and limiting clinical application. limits
When designing the porosity of these ceramic material systems, the application of the material is often affected due to the substantial reduction in the mechanical strength and toughness of the material.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 100 g of hydroxyapatite ceramic powder with an average particle size of 0.1 μm, 300 g of deionized water, 1.0 g of polyacrylic acid amine, 1.0 g of polyvinyl alcohol, and 40 g of starch, and use zirconia balls as the ball milling medium with a ball-to-material ratio of 4: 1. Mix at a speed of 300r / min for 8 hours; the resulting slurry is passed through a 60-mesh sieve after rotary evaporation, and the powder is machine-pressed under a pressure of 30MPa; The green body was placed in a high-temperature sintering furnace at 1000°C for 4 hours; the porosity of the prepared hydroxyapatite porous ceramics was 43.8%, and the compressive strength was 6.8MPa.

Embodiment 2

[0021] Weigh 100 g of hydroxyapatite ceramic powder with an average particle size of 0.5 μm, 200 g of deionized water, 0.7 g of polyacrylamide, 3.0 g of polyethylene glycol, 15 g of activated carbon powder, and 5 g of starch, and use zirconia balls as the ball milling medium. The ratio of ball to material is 2:1, and the mixture is mixed for 10 hours at a speed of 200r / min. The resulting slurry is passed through a 100-mesh sieve after rotary evaporation, and the powder is machine-pressed under a pressure of 100 MPa. The green body after demolding was kept in an oven at 120°C for 2h. The dried body was placed in a high-temperature sintering furnace at 1100° C. for 5 hours. The porosity of the prepared hydroxyapatite porous ceramics is 26.7%, and the compressive strength is 12.7MPa.

Embodiment 3

[0023] Weigh 100 g of hydroxyapatite ceramic powder with an average particle size of 1.0 μm, 200 g of deionized water, 0.6 g of polyacrylamine, 2.0 g of polyethylene glycol, and 15 g of polymethyl methacrylate microspheres. Ball milling medium, ball to material ratio 4:1, mixed at 100r / min for 12h. The resulting slurry is passed through a 200-mesh sieve after rotary evaporation, and the powder is machine-pressed under a pressure of 150 MPa. The green body after demoulding is kept at 150° C. for 0.5 h in an oven; the dried green body is placed in a high-temperature sintering furnace and kept at 1250° C. for 3 h. The porosity of the prepared hydroxyapatite porous ceramics is 18.5%, and the compressive strength is 18.9MPa.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
compressive strengthaaaaaaaaaa
compressive strengthaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of bioengineering and material science, and particularly relates to a preparation method of hydroxyapatite porous ceramic capable of being used as an artificial bone. The preparation process can be realized according to the following steps: taking deionized water, a dispersing agent, a binder, hydroxyapatite ceramic powder and a pore-forming agent as initial raw materials, and carrying out ball-milling mixing to obtain stably dispersed slurry; drying the obtained slurry in a rotary evaporator, and sieving the slurry for later use; carrying out mechanical press molding on the sieved powder, demolding the material, and drying the material in a drying oven; and sintering the dried green body in an air atmosphere furnace to obtain the hydroxyapatiteporous ceramic. The prepared material is reliable in performance, and has the characteristics of simple process, easiness in large-scale production and the like.

Description

technical field [0001] The invention belongs to the technical fields of bioengineering and material science, and in particular relates to a method for preparing porous hydroxyapatite ceramics that can be used as artificial bones. Background technique [0002] Bone defect is a common clinical case, and human bone transplantation is a common rehabilitation strategy. At present, the commonly used repair materials include autologous bone, allogeneic bone, and synthetic materials, all of which have certain deficiencies. Autologous bone has no immune rejection, and the repair effect is good, but whether the material is limited; allograft bone is widely used, but it is easy to cause immune rejection, and the repair effect is poor; in recent years, the research and application of artificial synthetic materials have made great progress. It provides a more feasible method for the repair of bone defects. At present, synthetic materials include polymer materials, titanium alloy materi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C04B38/06C04B35/622C04B35/447A61L27/56A61L27/12
CPCA61L27/12A61L27/56A61L2430/02C04B35/447C04B35/622C04B38/0645C04B38/067C04B38/068C04B2235/602C04B2235/6567C04B2235/96C04B38/0074
Inventor 袁波王刚王波
Owner SINOSTEEL LUOYANG INST OF REFRACTORIES RES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com