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A two-component cross-linked composite material applied to urology and its preparation method

A composite material and urological technology, applied in the field of medicine, can solve the problems of wound pain stimulation, difficult to remove or replace, and inelasticity, so as to improve biocompatibility, prevent inter-tissue adhesion, reduce or eliminate swelling effect

Active Publication Date: 2022-05-10
杭州仪文生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the obvious defects of the high molecular polymer organic solution itself, it cannot be used for tissue wound care after urological external genital plastic surgery: (1) the formed high molecular film has a strong adhesive force and it is difficult to tear it off or remove it. Replacement; (2) The formed polymer film cannot provide a physical barrier for the wound surface due to its small thickness and inelasticity to prevent foreign matter from irritating the tissue wound surface; (3) Can not provide a moist healing environment; (4) High molecular polymer The organic solution contains a large amount of organic solvent, which has a strong pain stimulating effect on the wound surface

Method used

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  • A two-component cross-linked composite material applied to urology and its preparation method
  • A two-component cross-linked composite material applied to urology and its preparation method
  • A two-component cross-linked composite material applied to urology and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0061] Obtaining of branched polylysine terminated by amino active group (first component raw material):

[0062] 1. G2-8NH 2 Branched polylysine has 8 branched chains, and each branched chain end contains an amino active group. The molecular structure is as follows figure 1 As shown, algebra: G2 (second generation), purchased from Weihai Chenyuan Molecular New Material Co., Ltd.

[0063] 2. G3-16NH 2 Branched polylysine, with 16 branched chains, each branched chain end contains an amino active group, the molecular structure is as follows figure 2 As shown, algebra: G3 (third generation), purchased from Weihai Chenyuan Molecular New Material Co., Ltd.

Embodiment 2

[0065] Preparation of branched polylysine terminated by maleimide active group (first component raw material)

[0066] 1. Preparation of G2-8EMCA branched polylysine:

[0067] Preparation of main raw materials: G2-8NH 2 Branched polylysine, succinimidyl 6-(maleimido)hexanoate (CAS No.: 55750-63-5).

[0068] Preparation principle: first, in anhydrous organic solvent, using G2-8NH 2 The amino group at the end of the branched polylysine branch is prone to nucleophilic substitution reaction with the succinimide ester of 6-(maleimido) hexanoic acid succinimide ester, and then in G2-8NH 2 Maleimide groups were introduced into branched polylysine.

[0069] making process:

[0070](1) 60 mass parts of 6-(maleimido) caproic acid succinimide esters are dissolved in 500 mass parts of dichloromethane to form a solution;

[0071] (2) 50 mass parts of G2-8NH 2 Branched polylysine is dissolved in 500 parts by mass of N,N-dimethylformamide / dichloromethane (volume ratio 2:3) to form a so...

Embodiment 3

[0087] Preparation of branched polylysine terminated by succinimide ester active group (first component raw material)

[0088] 1. Preparation of G2-8NHS branched polylysine:

[0089] Prepare main raw material: G2-8NH of embodiment 2 2 Branched polylysine, chloroacetic acid, N-hydroxysuccinimide (CAS No.: 6066-82-6).

[0090] Preparation principle: using G2-8NH 2 -NH on branched polylysine 2 Nucleophilic substitution reaction occurs with excess chloroacetic acid to form G2-8COOH branched polylysine, and -COOH on G2-8COOH branched polylysine reacts with catalyst 1-ethyl-(3-dimethylamino Propyl) carbodiimide hydrochloride (EDC.HCl) reacts with N-hydroxysuccinimide, and then introduces succinimide ester groups on the G2-8COOH branched polylysine.

[0091] making process:

[0092] (1) 60 mass parts of G2-8NH 2 The branched polylysine is dissolved in 600 parts by mass of sodium hydroxide solution with a mass concentration of 40% to 60%, and precooled, and the precooling temper...

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Abstract

The present invention proposes a two-component cross-linked composite material applied to urology, comprising a first component and a second component, the first component being a branched polylysine-bonded carboxylated active group-terminated Sodium methylcellulose recombinant macromolecular compound and branched polylysine bonded three-arm polyethylene glycol carboxylic acid capped with active group, or branched polylysine bonded carboxymethyl with capped active group Sodium cellulose recombinant polymer compound and branched polylysine bonded three-arm polyethylene glycol recombinant polymer compound capped with active groups, the first component has a branched chain, and the end of the branched chain contains an active group The second component is a polydextrose biocompatible polysaccharide crosslinking agent modified by an active group and a low molecular weight carboxymethylcellulose biocompatible polysaccharide crosslinking agent modified by an active group. The two-component cross-linked composite material applied to urology surgery can seal the postoperative wound of urology surgery, block external stimuli and bacteria, stop seepage, prevent adhesion, etc., and greatly promote healing.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a two-component cross-linked composite material used in urology and a preparation method thereof. Background technique [0002] In the process of external genital plastic surgery in urology (such as circumcision, vulva plastic surgery, etc.), it often involves excision or segmentation of primary tissue, separation or excision of hyperplastic tissue adhesion, electrocoagulation, and wound suture, etc., and new tissue wounds are generated during the surgical process. Clinically, this type of surgery has a high incidence of postoperative adverse reactions, including tissue adhesion, viral and bacterial infection, strong foreign body irritation, inflammation, swelling, long healing period, and unsightly healing of tissue wounds. This kind of operation is different from other surgical operations, and has high requirements on the repair effect and aesthetics of the new tis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/62A61K47/60A61L26/00
CPCA61L26/008A61L26/0019A61L26/0023A61L26/0076C08L87/00
Inventor 吴建华姚江平
Owner 杭州仪文生物医药有限公司
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