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Preparation method and application of total gingerol external preparation

An external preparation, the technology of total gingerol, which is applied in the field of preparation of total gingerol external preparation, can solve the problems of discomfort, skin irritation, redness, swelling, burning, etc., achieve the effect of reducing the main odor components and avoiding serious side effects

Inactive Publication Date: 2020-12-29
成都克洛玛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Secondly, the volatile oil components are easy to irritate the skin, and redness, swelling and burning are prone to occur after medication. Although most of them can be relieved by themselves, there is still a certain degree of discomfort. This phenomenon is more likely to occur after children take medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] The invention provides a kind of preparation method of total gingerol external preparation, comprises the following steps:

[0045] Step (1): Supercritical Extraction

[0046] Dried ginger is crushed into fine powder, and the fine powder is sieved and put into a supercritical carbon dioxide extraction kettle, and then supercritical carbon dioxide is used as a solvent for extraction, and an entrainer is added during the extraction process; the entrainer includes the following by mass: Components: 60%~70% ethanol, 5%~8% methylparaben, 2~3% triethanolamine and water;

[0047] The process parameters of supercritical extraction are: the extraction pressure is 25MPa~32Mpa, the extraction temperature is 52°C~60°C, the flow rate of carbon dioxide is controlled to 5L / h~15L / h, and the extraction time is 2h~4h; the flow rate of entrainer and carbon dioxide solvent The ratio is 2% to 5%; the material in the extraction kettle of the supercritical extraction equipment is centrifuged...

Embodiment 1

[0061] Embodiment 1: supercritical extraction

[0062] Grind dried ginger into fine powder, put the fine powder through a 50-mesh sieve into a supercritical carbon dioxide extraction kettle, then use supercritical carbon dioxide as a solvent for extraction, and add an entrainer during the extraction process; the entrainer includes the following by mass Calculated components: ethanol 70%, methylparaben 7%, triethanolamine 2% and 20% water.

[0063] The process parameters of supercritical extraction are: the extraction pressure is 30Mpa, the extraction temperature is 55°C, the flow rate of carbon dioxide is controlled to 12L / h, and the extraction time is 2.3h; the flow ratio of entrainer to carbon dioxide solvent is 2%; the supercritical extraction equipment The material in the extraction kettle is centrifuged to remove impurities to obtain the crude extract of total gingerols;

[0064] During the supercritical extraction process, the entrainer is added by continuous pumping; a...

Embodiment 2

[0065] Embodiment 2: macroporous resin column chromatography

[0066] (A) AB-8 macroporous resin is soaked in dilute alkaline solution with a pH of 7.8, soaked for 10 minutes, washed with deionized water until neutral, then soaked in ethyl acetate for 6 minutes, and then washed with deionized water again until neutral. A pretreated macroporous resin is obtained.

[0067] (B) Put the pretreated macroporous resin on the column by wet method, stir the macroporous resin and deionized water evenly, then add it to the glass chromatography column continuously, release the excess water from the bottom, and make the macroporous resin gradually settle to the middle of the glass chromatography column.

[0068] (C) Dissolve 1 part of total gingerol crude extract in 2 parts of methanol by weight, carry out centrifugation and precipitation filtration, and then add it to the top of the glass chromatography column, and wait until the mixture of total gingerol crude extract and methanol is sl...

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Abstract

The invention discloses a preparation method of a total gingerol external preparation. The preparation method comprises the steps of supercritical extraction, macroporous resin column chromatography,HPLC purification and preparation of a gel preparation, wherein the gel preparation is prepared from 100 parts of refined gingerol, 5-15g of carbomer, 20-30g of glycerin and 0.1-0.2g of polysorbate, and distilled water. According to the preparation method, the external preparation is prepared from total gingerol, so that the medicinal effect of total gingerol, such as removing heat, relieving painand the like can be utilized, and the serious effect on the digestive tract caused by taking oral medicines for a long time can be avoided.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a preparation method and application of a total gingerol external preparation. Background technique [0002] Rheumatoid arthritis (RA) is a chronic systemic disease with unknown etiology, mainly inflammatory synovitis. Its pathogenesis may be related to heredity, infection, sex hormones, etc. The pathology of RA arthritis mainly includes the proliferation of synovial lining cells, the infiltration of a large number of inflammatory cells in the interstitium, the neogenesis of microvessels, the formation of pannus, and the destruction of cartilage and bone tissue. Rheumatoid arthritis is a common acute or chronic inflammation of connective tissue. Commonly said rheumatoid arthritis is one of the main manifestations of rheumatic fever, clinically characterized by joint and muscle migratory soreness, redness and pain. It is related to group A beta-hemolytic st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/06A61P19/02A61P29/00A61P31/04A61P31/10
CPCA61K9/0014A61K9/06A61K36/9068A61K2236/37A61K2236/55A61P19/02A61P29/00A61P31/04A61P31/10
Inventor 肖峰
Owner 成都克洛玛生物科技有限公司
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